Phytochemical Composition and Biological Activities of Dyssodia tagetiflora Lag

• Published in: Chemistry & biodiversity Vol. 15; no. 2
• Main Authors: García‐Bores, Ana María, Arciniegas‐Arciniegas, Amira, Reyna‐Campos, Alma, Céspedes‐Acuña, Carlos, Avila‐Suárez, Betsaida, Alarcón‐Enos, Julio, Flores‐Maya, Saul, Espinosa‐González, Adriana Montserrat, Vivar‐Romo, Alfonso Romo, Pérez‐Plasencia, Carlos, Avila‐Acevedo, José Guillermo
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01-02-2018
• Subjects: Animals; antioxidant activities; Antioxidants; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Biological activity; Cell Line; Cell Survival - drug effects; Chemical composition; cytoprotection; Cytotoxicity; Dose-Response Relationship, Drug; Drosophila - chemistry; Drosophila melanogaster - drug effects; Dyssodia; Dyssodia tagetiflora; Endemic plants; essential oil; Essential oils; Flavonols; Fodder; Fruit flies; Genotoxicity; Glycosides; Humans; Hydrogen peroxide; Larvae; Micronuclei; Monoterpenes; NMR; Nuclear magnetic resonance; Oils & fats; Oils, Volatile - chemistry; Oils, Volatile - isolation & purification; Oils, Volatile - pharmacology; Pharmacology; Phytochemicals; Phytochemicals - chemistry; Phytochemicals - isolation & purification; Phytochemicals - pharmacology; Plant Components, Aerial - chemistry; Plants (botany); quercetin‐glycosides; Spectrometry; Structure-Activity Relationship; Thiophenes; Vicia faba; antioxidant activities; quercetin-glycosides; essential oil; cytoprotection; Dyssodia tagetiflora
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.201700415

While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pharmacological studies have been performed with species of this genus. D. tagetiflora is an endemic plant of Mexico and has been used as fodder. The aim of this research was to isolate and identify the main bioactive components and evaluate the insecticidal, antioxidant, genotoxic and cytoprotective activities of D. tagetiflora. The isolated substances included an essential oil composed of six monoterpenes, and extracts containing two flavonols, three flavonol‐glycosides and four thiophenes. The compounds were characterized using spectroscopic and spectrometric methods, including GC/MS, MS and NMR. The essential oil showed insecticidal activity against Drosophila melanogaster larvae. The methanolic extract of D. tagetiflora (DTME) had strong antioxidant activity against DPPH and ABTS radicals; DTME showed no evidence of genotoxic or cytotoxic effects. In contrast, DTME showed a cytoprotective effect attenuating the formation of H2O2‐induced micronuclei in Vicia faba roots. This report is the first to describe the phytochemical and biological activity of D. tagetiflora.