Bisphosphonate-induced osteoradionecrosis

Bisphosphonate-induced osteoradionecrosis

Bisphosphonates (BPs) are a class of agents used to treat osteoporosis and malignant bone metastasis. Despite these benefits, osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs. This case presentation focuses on a 62-year-old ma...

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Bibliographic Details
Published in:Journal of oral and maxillofacial pathology : JOMFP Vol. 17; no. 3; pp. 460 - 462
Main Authors: Bhuyan, Ruchi, Bhuyan, Sanat, Panigrahi, Rajat G, Panigrahi, Antarmayee
Format: Journal Article
Language:English
Published: India Medknow Publications and Media Pvt. Ltd 01-09-2013
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Subjects:
Bones
Case Report
Case studies
Complications and side effects
Diphosphonates
Medical research
Medicine, Experimental
Mouth diseases
Multiple myeloma
Necrosis
multiple myeloma
zolendronic acid
BRONJ
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Summary:Bisphosphonates (BPs) are a class of agents used to treat osteoporosis and malignant bone metastasis. Despite these benefits, osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs. This case presentation focuses on a 62-year-old man with a 3-year history of monthly use of Zometa (zolendronic acid) for treatment of multiple myeloma, resulting in BP-related osteoradionecrosis of the jaws (BRONJ). This new entity remains a challenge with diagnosis as well as treatment. The goal of this paper is to improve clinicians understanding and provide a guideline for establishing a stage-specific diagnosis and prevention of BRONJ.
ISSN:0973-029X
1998-393X
DOI:10.4103/0973-029X.125221