Cladribine in the remission induction of adult acute myeloid leukemia: where do we stand?

• Published in: Annals of hematology Vol. 98; no. 3; pp. 561 - 579
• Main Authors: Qasrawi, Ayman, Bahaj, Waled, Qasrawi, Lien, Abughanimeh, Omar, Foxworth, John, Gaur, Rakesh
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2019; Springer Nature B.V
• Subjects: Chemotherapy; Hematology; Leukemia; Medicine; Medicine & Public Health; Oncology; Remission (Medicine); Review Article; Remission; Chemotherapy; Induction; Acute myeloid leukemia; Cladribine
• ISSN: 0939-5555; 1432-0584
• DOI: 10.1007/s00277-018-3562-8

The combination of cytarabine and an anthracycline has been the standard of care for the induction of remission in acute myeloid leukemia (AML). The response to treatment and survival of adult patients with AML are still variable and depend on multiple factors. Therefore, there have been many efforts to improve the response to treatment and survival rates by either increasing the cytarabine dose or adding a third agent to the standard induction chemotherapy regimen. Unfortunately, attempts to improve response and survival have been mostly unsuccessful. Recent clinical trials and retrospective studies explored the addition of cladribine to standard induction chemotherapy for AML. Some of these studies showed higher rates of complete remission, and one showed improved survival. In this review, we will discuss the antileukemic properties of cladribine and summarize the recent clinical data regarding its incorporation into the induction therapy for adult AML.