Effects of the monoamine stabilizer (−)-OSU6162 on locomotor and sensorimotor responses predictive of antipsychotic activity

The monoamine stabilizer (3S)-3-[3-(methenesulfonyl)phenyl]-1-propylpiperidine hidrochloride [(−)-OSU6162] is a promising compound for the treatment of neurological and psychiatric disorders, such as schizophrenia. Here, we tested the hypothesis that (−)-OSU6162 prevents hyperlocomotion and sensorim...

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Bibliographic Details
Published in:	Naunyn-Schmiedeberg's archives of pharmacology Vol. 391; no. 7; pp. 761 - 768
Main Authors:	da Silveira, Vívian T., Röpke, Jivago, Matosinhos, Ana L., Issy, Ana C., Del Bel, Elaine A., de Oliveira, Antônio C., Moreira, Fabrício A.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-07-2018 Springer Nature B.V
Subjects:	Animals Antipsychotic Agents - pharmacology Antipsychotics Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Catalepsy Cocaine Cocaine - pharmacology Dizocilpine Dopamine Dopamine receptors Dopamine transporter Dopamine Uptake Inhibitors - pharmacology Drug abuse Drug dosages Excitatory Amino Acid Antagonists - pharmacology Extrapyramidal system Glutamatergic transmission Hyperactivity Ketamine Ketamine - pharmacology Liability Locomotion Locomotion - drug effects Male Mental disorders Mice N-Methyl-D-aspartic acid Neurological diseases Neurosciences Original Article Pharmacology/Toxicology Piperidines - pharmacology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Reflex, Startle - drug effects Schizophrenia Schizophrenia - drug therapy Sensorimotor system Side effects Startle response Schizophrenia Antipsychotics Animal models Dopamine Glutamate
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