Total synthesis of aculeatins A and B from d-glucose

A simple and highly efficient total synthesis of cytotoxic dioxa-dispiroketals aculeatins A and B is disclosed. The key steps include alkynylation of a chiral aldehyde and in situ deprotection, spirocyclization of a 3,5-acetonide protected ketone.

Bibliographic Details

Published in:	Tetrahedron: asymmetry Vol. 19; no. 12; pp. 1509 - 1513
Main Authors:	Suresh, Vangaru, Jon Paul Selvam, Jondoss, Rajesh, Karuturi, Venkateswarlu, Yenamandra
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 30-06-2008
Online Access:	Get full text
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