Upright T wave in precordial lead V1 indicates the presence of significant coronary artery disease in patients undergoing coronary angiography with otherwise unremarkable electrocardiogram

• Published in: Herz Vol. 37; no. 7; pp. 756 - 761
• Main Authors: Stankovic, I., Milekic, K., Vlahovic Stipac, A., Putnikovic, B., Panic, M., Vidakovic, R., Aleksic, A., Milicevic, P., Neskovic, A.N.
• Format: Journal Article
• Language: English
• Published: Munchen Urban and Vogel 01-11-2012; Springer Nature B.V
• Subjects: Cardiology; Coronary Angiography - statistics & numerical data; Coronary Artery Disease - diagnosis; Coronary Artery Disease - epidemiology; Electrocardiography - methods; Electrocardiography - statistics & numerical data; Female; Germany - epidemiology; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Prevalence; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Germany; Upright T wave in lead V1; Risikobeurteilung; Risikofaktoren; Electrocardiogram; Risk assessment; Koronare Herzkrankheit; Elektrokardiogramm; Positive T-Welle in Ableitung V1; Coronary artery disease; Risk factors
• ISSN: 0340-9937; 1615-6692
• DOI: 10.1007/s00059-011-3577-6

Objective
The goal of the current work was to assess the possible relationship between upright T wave in precordial lead V1 (TV1) and the occurrence of coronary artery disease (CAD) in patients undergoing coronary angiography with an otherwise unremarkable resting electrocardiogram (ECG).
Methods
Twelve-lead resting ECGs of 2,468 patients who underwent coronary angiography were analyzed by independent reviewers blinded to the patients’ clinical data. Patients with any condition known to affect cardiac repolarization were not eligible for inclusion.
Results
Of 126 patients included in the study, 76 (60%) had at least one significant coronary artery stenosis. Significant CAD was more frequently found in patients with upright TV1 as compared to those with negative TV1 (74 vs. 43%, p = 0.001). Left circumflex (LCx) and left anterior descending (LAD) coronary artery lesions were more frequently observed in patients with upright TV1 than in those with inverted TV1. In univariate analysis, patients with upright TV1 were approx 4 times more likely to have significant CAD than those with inverted TV1 (odds ratio (OR) 3.7, 95% confidence interval (CI) 1.744–7.897). In addition, in the multivariate logistic regression model, upright TV1 was an independent predictor of significant CAD (OR 4.249, 95% CI 1.594–11.328), along with previous myocardial infarction (OR 17.533, 95% CI 3.338–92.091), male gender (OR 3.020; 95% CI 1.214–7.510), and age (OR 1.061; 95% CI 1.003–1.122).
Conclusion
It might be worthwhile to routinely evaluate the polarity of the T wave in lead V1 in patients with suspected CAD, since it appears to have additional risk stratification potential.