Related factors of dental caries and molar incisor hypomineralisation in a group of children with cystic fibrosis

• Published in: European archives of paediatric dentistry Vol. 15; no. 4; pp. 275 - 280
• Main Authors: Peker, S., Mete, S., Gokdemir, Y., Karadag, B., Kargul, B.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-08-2014; Springer Nature B.V
• Subjects: Adolescent; Anti-Bacterial Agents - therapeutic use; Antibiotics; Brushing; Buffers; Chi-square test; Child; Children; Cohort Studies; Cystic fibrosis; Cystic Fibrosis - complications; Cystic Fibrosis - drug therapy; Dental caries; Dental Caries - complications; Dental enamel; Dental Enamel Hypoplasia - complications; Dentistry; Diet; Disease; DMF Index; Female; Humans; Hydrogen-Ion Concentration; Male; Medicine; Oral Hygiene; Original Scientific Article; Outpatient care facilities; Pediatrics; Saliva - chemistry; Saliva - physiology; Secretory Rate - physiology; Statistical analysis; Teeth; Tobramycin - therapeutic use; Toothbrushing - methods; Dental caries; Cystic fibrosis; Molar incisor hypomineralisation; Children; Saliva
• ISSN: 1818-6300; 1996-9805
• DOI: 10.1007/s40368-014-0112-5

Aim
To investigate dental caries and molar incisor hypomineralisation (MIH)-related factors such as treatment, diet, brushing and salivary factors in children with cystic fibrosis (CF) compared with healthy peers.
Study design
A cohort study was performed.
Methods
This study was performed on 30 CF children comprising patients at the Faculty of Medicine and 30 control children recruited from the Dental School. Salivary factors, dental caries, MIH, daily diet, brushing habits were analysed. Statistical analysis was calculated by SPSS for Windows.
Results
Decay missing filled teeth (DMF-T) score was 4.6 ± 4.0 in CF and 7.7 ± 2.7 in control (
p
 = 0.001). 43 % of CF children with MIH were found to use antibiotics, but no significant difference in the caries experience was found with antibiotic usage (
p
 > 0.05). DMF-T of CF adolescents (23 %) who use Tobramycin was 7 ± 3.5. DMF-T of CF children (20 %) who take other antibiotics was 2.5 ± 3.5, but no statistical difference was found (
p
 = 0.054). Saliva pH, salivary flow rate, and buffering capacity were not found statistically significant (
p
 > 0.05).
Statistics
Percentage arithmetic mean value, standard deviation, independent sample
t
test, Fisher’s exact test, Chi-square test and Mann–Whitney
U
test were used, while a
p
value of <0.05 was considered statistically significant.
Conclusions
Medication and diet could be considered as a risk factor for dental caries and factors such as salivary pH, good oral hygiene could play a protective role for oral health CF children. MIH frequency and lower caries experience seen in CF children could be due to salivary factors or pharmacological treatment they take. The multidisciplinary approach team would be advantageous in the management of children with CF and oral health should be under control during early years of life by paediatric dentists.