Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice

• Published in: Biogerontology (Dordrecht) Vol. 17; no. 2; pp. 317 - 324
• Main Authors: Panchenko, Andrey V., Popovich, Irina G., Trashkov, Alexandr P., Egormin, Peter A., Yurova, Maria N., Tyndyk, Margarita L., Gubareva, Ekaterina A., Artyukin, Ilia N., Vasiliev, Andrey G., Khaitsev, Nikolai V., Zabezhinski, Mark A., Anisimov, Vladimir N.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-04-2016; Springer Nature B.V
• Subjects: Age; Aging; Animals; Biomarkers; Biomarkers - metabolism; Biomedical and Life Sciences; Cancer; Carcinogenesis; Cell Biology; Developmental Biology; Embryos; Female; Genes, erbB-2; Geriatrics/Gerontology; Insulin-like growth factors; Life Sciences; Metabolism; Mice; Mice, Transgenic; Oncology; Research Article; Research centers; Tumors; Vascular endothelial growth factor; St Petersburg Russia; Russia; Biomarkers of aging; HER-2/neu; FVB/N mice; Life span; Spontaneous carcinogenesis
• ISSN: 1389-5729; 1573-6768
• DOI: 10.1007/s10522-015-9611-y

FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malonic dialdehyde, catalase, Cu, Zn-superoxide dismutase, vascular endothelial growth factor were studied in both mice strains. The parameters of life span and tumor pathology were studied as well. Cancer-prone transgenic HER-2/neu mice developed in 100 % multiple mammary adenocarcinomas and died before the age of 1 year. Forty tree percent of long-lived wild type mice survived the age of 2 years and 19 %—800 days. The total tumor incidence in wild type mice was 34 %. The age-associated changes in the level of serum IGF-1, glucose and insulin started much earlier in transgene HER-2/neu mice as compared with wild type FVB/N mice. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis.