Ischemic stroke due to protein C deficiency

Plasma protein C exerts anticoagulatory effects by inactivating factors V and VIII. Hereditary protein C deficiency is transmitted as an autosomal dominant disorder. Homozygous individuals usually develop purpura fulminans as newborns; heterozygous protein C-deficient individuals are at increased ri...

Full description

Saved in:

Bibliographic Details
Published in:	Stroke (1970) Vol. 21; no. 7; pp. 1077 - 1080
Main Authors:	Kohler, J, Kasper, J, Witt, I, von Reutern, G M
Format:	Journal Article
Language:	English
Published:	United States 01-07-1990
Subjects:	Adult Brain Ischemia - diagnosis Brain Ischemia - etiology Female Genetic Carrier Screening Humans Intracranial Embolism and Thrombosis - diagnosis Intracranial Embolism and Thrombosis - etiology Male Pedigree Protein C - genetics Protein C Deficiency Risk Factors Ultrasonography
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Plasma protein C exerts anticoagulatory effects by inactivating factors V and VIII. Hereditary protein C deficiency is transmitted as an autosomal dominant disorder. Homozygous individuals usually develop purpura fulminans as newborns; heterozygous protein C-deficient individuals are at increased risk for venous thrombosis and pulmonary embolism. However, arterial thrombosis has been only rarely observed. We describe a young patient with heterozygous protein C deficiency who experienced a severe stroke due to thrombotic occlusion of the left middle cerebral artery.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0039-2499 1524-4628
DOI:	10.1161/01.STR.21.7.1077