Past, present and future perspectives in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four decades ago. However, the condition has become the centre of attention within hepatology owing to its high prevalence and growing contribution to the burden of end-stage liver disease in the general popul...

Full description

Saved in:

Bibliographic Details
Published in:	Nature reviews. Gastroenterology & hepatology Vol. 16; no. 6; pp. 377 - 386
Main Author:	Sanyal, Arun J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-06-2019 Nature Publishing Group
Subjects:	692/4020/1503/1607/2750 692/4020/2741/288 692/4020/4021/1607/2751 Alcohol use Biomedicine Disease Progression End Stage Liver Disease - epidemiology End Stage Liver Disease - etiology Fatty liver Gastroenterology Global Health Hepatology Humans Liver diseases Medicine Medicine & Public Health Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - epidemiology Perspective Prevalence
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four decades ago. However, the condition has become the centre of attention within hepatology owing to its high prevalence and growing contribution to the burden of end-stage liver disease in the general population. This Perspective provides an overview on the development of knowledge related to NAFLD with a focus on landmark findings that have influenced current paradigms and key knowledge gaps that need to be filled to make progress. Specifically, a timeline of scientific discovery of both basic disease mechanisms (with a focus on human data) and the evolution of knowledge about the clinical course of the disease is provided and related to current approaches to treat and eventually prevent NAFLD. Nonalcoholic fatty liver disease (NAFLD) was first described four decades ago, but it is increasingly important owing to its high prevalence in the general population. This Perspective provides an overview on the development of knowledge related to NAFLD, focusing on landmark findings.
AbstractList	Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four decades ago. However, the condition has become the centre of attention within hepatology owing to its high prevalence and growing contribution to the burden of end-stage liver disease in the general population. This Perspective provides an overview on the development of knowledge related to NAFLD with a focus on landmark findings that have influenced current paradigms and key knowledge gaps that need to be filled to make progress. Specifically, a timeline of scientific discovery of both basic disease mechanisms (with a focus on human data) and the evolution of knowledge about the clinical course of the disease is provided and related to current approaches to treat and eventually prevent NAFLD.Nonalcoholic fatty liver disease (NAFLD) was first described four decades ago, but it is increasingly important owing to its high prevalence in the general population. This Perspective provides an overview on the development of knowledge related to NAFLD, focusing on landmark findings. Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four decades ago. However, the condition has become the centre of attention within hepatology owing to its high prevalence and growing contribution to the burden of end-stage liver disease in the general population. This Perspective provides an overview on the development of knowledge related to NAFLD with a focus on landmark findings that have influenced current paradigms and key knowledge gaps that need to be filled to make progress. Specifically, a timeline of scientific discovery of both basic disease mechanisms (with a focus on human data) and the evolution of knowledge about the clinical course of the disease is provided and related to current approaches to treat and eventually prevent NAFLD. Nonalcoholic fatty liver disease (NAFLD) was first described four decades ago, but it is increasingly important owing to its high prevalence in the general population. This Perspective provides an overview on the development of knowledge related to NAFLD, focusing on landmark findings. Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four decades ago. However, the condition has become the centre of attention within hepatology owing to its high prevalence and growing contribution to the burden of end-stage liver disease in the general population. This Perspective provides an overview on the development of knowledge related to NAFLD with a focus on landmark findings that have influenced current paradigms and key knowledge gaps that need to be filled to make progress. Specifically, a timeline of scientific discovery of both basic disease mechanisms (with a focus on human data) and the evolution of knowledge about the clinical course of the disease is provided and related to current approaches to treat and eventually prevent NAFLD.
Author	Sanyal, Arun J.
Author_xml	– sequence: 1 givenname: Arun J. surname: Sanyal fullname: Sanyal, Arun J. email: arun.sanyal@vcuhealth.org organization: Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, School of Medicine
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31024089$$D View this record in MEDLINE/PubMed
BookMark	eNp1kE1LxDAQhoOsuB_6A7xIwIsHq_lo2uQoix8LC3rQc8imE-3SbWvSCvvvTdl1BcHDMAPzzPsy7xSN6qYGhM4puaGEy9uQUpGLhFAVK00TeYQmNBcqEUTw0WFOxRhNQ1gTkgnB1Qkac0pYSqSaoMWLCd01bj0EqDts6gK7vus94BZ8aMF25RcEXNY4epvKNh9NVVrsTNdtcRV3HhdlABPgFB07UwU42_cZenu4f50_Jcvnx8X8bplYnrMuUU4wljlYOapyTlmuJCNpukqNtFlhjVMZzzg4BUQQKSxZ2fhkzguSg8gl8Bm62um2vvnsIXR6UwYLVWVqaPqgGaMZk4JmMqKXf9B10_v4xkBxGp24GCi6o6xvQvDgdOvLjfFbTYkecta7nHXMWQ856-HmYq_crzZQHC5-go0A2wEhrup38L_W_6t-A46NiL4
CitedBy_id	crossref_primary_10_1016_j_jlr_2022_100238 crossref_primary_10_21673_anadoluklin_824294 crossref_primary_10_3390_metabo12030238 crossref_primary_10_14218_JCTH_2020_00183 crossref_primary_10_1007_s00330_023_10131_2 crossref_primary_10_2196_52576 crossref_primary_10_3390_cells11203216 crossref_primary_10_1016_S2468_1253_19_30383_8 crossref_primary_10_3389_fphar_2023_1152042 crossref_primary_10_1111_jcmm_15230 crossref_primary_10_1002_hep_31428 crossref_primary_10_1016_j_metabol_2021_154797 crossref_primary_10_1007_s40620_020_00751_y crossref_primary_10_3390_metabo13030444 crossref_primary_10_1080_17474124_2021_1903318 crossref_primary_10_1016_j_jhep_2022_06_012 crossref_primary_10_1016_j_tem_2019_08_006 crossref_primary_10_1056_NEJMoa2028395 crossref_primary_10_1002_iid3_370 crossref_primary_10_1007_s40619_022_01064_x crossref_primary_10_1016_j_jhepr_2021_100323 crossref_primary_10_1155_2020_3413186 crossref_primary_10_1002_1878_0261_13646 crossref_primary_10_1002_jsfa_12854 crossref_primary_10_1080_17474124_2020_1715210 crossref_primary_10_3390_cancers12102755 crossref_primary_10_1016_j_jhep_2022_06_018 crossref_primary_10_1002_jcsm_12646 crossref_primary_10_1002_oby_23294 crossref_primary_10_1038_s41467_023_36776_7 crossref_primary_10_1016_j_jacl_2019_10_006 crossref_primary_10_3390_nu12113379 crossref_primary_10_3389_fimmu_2022_965548 crossref_primary_10_1007_s11010_024_04957_7 crossref_primary_10_1016_j_apsb_2022_08_019 crossref_primary_10_1038_s41467_023_39311_w crossref_primary_10_1136_bmjopen_2020_039804 crossref_primary_10_1016_j_cbi_2020_109054 crossref_primary_10_1016_j_lfs_2020_118668 crossref_primary_10_15421_022201 crossref_primary_10_1080_14656566_2024_2374463 crossref_primary_10_1111_eci_13939 crossref_primary_10_3389_fnut_2022_1051157 crossref_primary_10_3389_fphar_2024_1343193 crossref_primary_10_1016_j_molmet_2020_101143 crossref_primary_10_1080_00365521_2022_2148835 crossref_primary_10_4254_wjh_v16_i5_688 crossref_primary_10_1016_j_joim_2021_07_004 crossref_primary_10_1016_j_dld_2020_04_019 crossref_primary_10_1186_s12876_022_02576_4 crossref_primary_10_3389_fmed_2023_1160053 crossref_primary_10_1111_liv_15578 crossref_primary_10_1038_s41575_019_0239_2 crossref_primary_10_1364_BOE_395890 crossref_primary_10_29169_1927_5951_2021_11_01 crossref_primary_10_1038_s41467_022_33840_6 crossref_primary_10_1155_2020_8786424 crossref_primary_10_3390_ijms23116270 crossref_primary_10_1111_liv_14251 crossref_primary_10_3390_md17110645 crossref_primary_10_1097_MEG_0000000000002686 crossref_primary_10_3390_acoustics3010002 crossref_primary_10_1002_advs_202400596 crossref_primary_10_1111_liv_14818 crossref_primary_10_1016_j_jhep_2023_05_034 crossref_primary_10_1210_endocr_bqaa089 crossref_primary_10_1016_j_yexcr_2023_113631 crossref_primary_10_3389_fimmu_2022_857892 crossref_primary_10_1016_j_mri_2024_01_013 crossref_primary_10_58961_hmj_1190766 crossref_primary_10_3350_cmh_2022_0330 crossref_primary_10_3892_mmr_2021_12463 crossref_primary_10_3389_fmicb_2023_1147067 crossref_primary_10_3390_nu11123044 crossref_primary_10_3233_CH_209213 crossref_primary_10_1016_j_jhep_2020_02_028 crossref_primary_10_29254_2077_4214_2019_3_152_196_200 crossref_primary_10_1007_s10620_020_06672_x crossref_primary_10_3390_ijms25115822 crossref_primary_10_1038_s41575_020_00408_y crossref_primary_10_3390_ijms22084282 crossref_primary_10_3390_biomedicines11123255 crossref_primary_10_1007_s11307_022_01798_y crossref_primary_10_1039_D2RA05750F crossref_primary_10_3389_fimmu_2020_634409 crossref_primary_10_1096_fj_202002671RR crossref_primary_10_1186_s12944_019_1179_0 crossref_primary_10_1155_2021_3877617 crossref_primary_10_1016_j_pestbp_2023_105702 crossref_primary_10_1002_advs_202002997 crossref_primary_10_1002_jmri_28765 crossref_primary_10_1089_ars_2021_0044 crossref_primary_10_1002_ctd2_9 crossref_primary_10_3390_metabo12060528 crossref_primary_10_1016_j_biopha_2020_111104 crossref_primary_10_1016_j_ejphar_2023_176215 crossref_primary_10_1038_s41366_023_01435_w crossref_primary_10_1007_s11357_022_00713_1 crossref_primary_10_2337_db20_0146 crossref_primary_10_4254_wjh_v13_i11_1584 crossref_primary_10_1002_ygh2_397 crossref_primary_10_1155_2022_4797453 crossref_primary_10_1210_clinem_dgac321 crossref_primary_10_1097_MD_0000000000025358 crossref_primary_10_3390_ijms23126384 crossref_primary_10_1039_D0FO02736G crossref_primary_10_1016_j_cmet_2021_05_019 crossref_primary_10_3390_microorganisms8101526 crossref_primary_10_22416_1382_4376_2021_31_2_14_26 crossref_primary_10_1039_D3FO02653A crossref_primary_10_3389_fendo_2021_721135 crossref_primary_10_3389_fimmu_2020_627424 crossref_primary_10_1016_j_diabres_2023_110679 crossref_primary_10_1016_j_cgh_2022_09_028 crossref_primary_10_3389_fphys_2021_728407 crossref_primary_10_1002_advs_202104373 crossref_primary_10_1016_j_aohep_2019_11_010 crossref_primary_10_3390_antiox10040565 crossref_primary_10_3390_antiox11050905 crossref_primary_10_2147_DMSO_S380053 crossref_primary_10_1111_ijcp_13985 crossref_primary_10_1111_jcmm_15166 crossref_primary_10_1016_j_molmet_2022_101462 crossref_primary_10_3390_nu15061359 crossref_primary_10_3389_fimmu_2022_925690 crossref_primary_10_1016_j_biocel_2024_106517 crossref_primary_10_1148_radiol_222008 crossref_primary_10_1111_febs_15877 crossref_primary_10_1002_hep_31599 crossref_primary_10_1016_j_semcdb_2020_04_011 crossref_primary_10_1016_j_fct_2021_112314 crossref_primary_10_1016_j_jhepr_2021_100234 crossref_primary_10_3390_ijms25105446 crossref_primary_10_3390_v13122506 crossref_primary_10_3389_ijph_2023_1605031 crossref_primary_10_1038_s41591_023_02539_6 crossref_primary_10_1021_acsmaterialslett_3c00881 crossref_primary_10_1016_j_freeradbiomed_2021_03_015 crossref_primary_10_1016_j_jhep_2023_04_025 crossref_primary_10_1172_JCI151895 crossref_primary_10_1002_hep_31801 crossref_primary_10_1038_s41575_020_00386_1 crossref_primary_10_3390_antiox10071076 crossref_primary_10_1111_jdi_13562 crossref_primary_10_3390_ijms21072391 crossref_primary_10_1159_000527027 crossref_primary_10_1002_jgh3_12716 crossref_primary_10_1016_j_livres_2022_09_003 crossref_primary_10_1136_bmjopen_2020_045498 crossref_primary_10_1155_2020_8829346 crossref_primary_10_3390_ijms21175999 crossref_primary_10_3390_biomedicines9070762 crossref_primary_10_1177_15353702211009228 crossref_primary_10_3350_cmh_2020_0100 crossref_primary_10_1016_j_bbalip_2019_158597 crossref_primary_10_3390_ijms25094916 crossref_primary_10_3390_nu13020652 crossref_primary_10_3350_cmh_2022_0096 crossref_primary_10_2147_DMSO_S428523 crossref_primary_10_1007_s11695_022_06153_2 crossref_primary_10_1016_j_biopha_2021_112298 crossref_primary_10_1016_j_bbrc_2024_150305 crossref_primary_10_3390_ijms23031062 crossref_primary_10_2174_1574885518666230417111247 crossref_primary_10_3390_jcm12062126 crossref_primary_10_3390_biomedicines10061291 crossref_primary_10_3389_fnut_2021_760985 crossref_primary_10_17235_reed_2022_8777_2022 crossref_primary_10_1002_hep_31031 crossref_primary_10_1016_j_phymed_2022_154444 crossref_primary_10_3389_fendo_2021_639548 crossref_primary_10_1002_hep_31390 crossref_primary_10_1186_s12967_024_05060_7 crossref_primary_10_2147_DMSO_S396335 crossref_primary_10_1038_s41584_022_00883_4 crossref_primary_10_1126_scitranslmed_abg8116 crossref_primary_10_3389_fmolb_2021_792667 crossref_primary_10_3390_ijms21165888 crossref_primary_10_1177_01926233231171101 crossref_primary_10_2147_JIR_S440430 crossref_primary_10_1016_j_cmet_2023_10_008 crossref_primary_10_1007_s10695_022_01060_w crossref_primary_10_1016_j_jhep_2022_04_002 crossref_primary_10_1016_S0140_6736_20_32511_3 crossref_primary_10_1016_j_jhepr_2022_100563 crossref_primary_10_1016_j_numecd_2024_04_004 crossref_primary_10_1016_j_freeradbiomed_2020_02_025 crossref_primary_10_1159_000507233 crossref_primary_10_1002_hep_31040 crossref_primary_10_1016_j_eprac_2022_03_016 crossref_primary_10_1186_s12944_021_01560_3 crossref_primary_10_1007_s00592_024_02292_3 crossref_primary_10_1111_liv_14799 crossref_primary_10_1360_SSV_2021_0098 crossref_primary_10_3390_jcm11206205 crossref_primary_10_1016_j_heliyon_2023_e22464 crossref_primary_10_1007_s10620_021_07363_x crossref_primary_10_3389_fpubh_2022_895045 crossref_primary_10_3390_metabo10030104 crossref_primary_10_1186_s12967_024_04885_6 crossref_primary_10_1155_2022_4369329 crossref_primary_10_3389_fendo_2023_1115890 crossref_primary_10_1007_s10753_022_01727_9 crossref_primary_10_1186_s12902_023_01427_x crossref_primary_10_1002_oby_23576 crossref_primary_10_33590_emjhepatol_22_00150 crossref_primary_10_1186_s41747_019_0137_y crossref_primary_10_3389_fphar_2023_1253715 crossref_primary_10_1002_hep4_1473 crossref_primary_10_1007_s12325_021_01690_1 crossref_primary_10_1016_j_aca_2024_342802 crossref_primary_10_1016_j_chemosphere_2024_141442 crossref_primary_10_1038_s41366_023_01439_6 crossref_primary_10_1080_15592294_2022_2043590 crossref_primary_10_1111_liv_15619 crossref_primary_10_1093_hmg_ddaa162 crossref_primary_10_1111_and_14091 crossref_primary_10_1016_j_cgh_2022_01_020 crossref_primary_10_3390_ijerph19169935 crossref_primary_10_1016_j_atherosclerosis_2022_08_011 crossref_primary_10_1016_j_lfs_2019_117010 crossref_primary_10_3389_fmed_2020_00448 crossref_primary_10_3390_cells10092273 crossref_primary_10_1021_acsptsci_0c00208 crossref_primary_10_3390_ijms23105544 crossref_primary_10_3389_fmed_2024_1410668 crossref_primary_10_3390_cells10081945 crossref_primary_10_1038_s41598_021_98685_3 crossref_primary_10_1186_s12951_022_01540_4 crossref_primary_10_3892_ijmm_2024_5356 crossref_primary_10_3390_ijms23158387 crossref_primary_10_1016_j_cgh_2021_09_023 crossref_primary_10_2174_1386207326666230614102412 crossref_primary_10_1016_j_jhep_2021_03_006 crossref_primary_10_1016_S2468_1253_22_00317_X crossref_primary_10_1111_liv_15503 crossref_primary_10_1111_liv_15866 crossref_primary_10_3390_jcm11051445 crossref_primary_10_1111_eci_13648 crossref_primary_10_1161_JAHA_123_031230 crossref_primary_10_1016_j_phymed_2023_155287 crossref_primary_10_1002_ygh2_367 crossref_primary_10_3390_ijms231810897 crossref_primary_10_1371_journal_pone_0249493 crossref_primary_10_3389_fmed_2022_985803 crossref_primary_10_1186_s13578_022_00910_7 crossref_primary_10_1038_s41591_023_02242_6 crossref_primary_10_1080_1744666X_2022_2045952 crossref_primary_10_3748_wjg_v28_i48_6909 crossref_primary_10_1002_hep_32165 crossref_primary_10_1021_acsnano_1c02158 crossref_primary_10_1002_hep_31197 crossref_primary_10_1016_j_envres_2023_116651 crossref_primary_10_3390_jpm13020209 crossref_primary_10_1096_fj_202000194R crossref_primary_10_3389_fcvm_2022_891963 crossref_primary_10_1111_liv_15555 crossref_primary_10_1021_acs_jafc_4c00590 crossref_primary_10_1016_j_semcdb_2020_02_012 crossref_primary_10_3390_ijms232314762 crossref_primary_10_1016_j_jhep_2021_02_037 crossref_primary_10_1111_liv_14473 crossref_primary_10_1055_s_0041_1730927 crossref_primary_10_3389_fphar_2022_971561 crossref_primary_10_3389_fcimb_2022_870785 crossref_primary_10_1096_fj_202000683R crossref_primary_10_22141_2308_2097_55_1_2021_229433 crossref_primary_10_1016_j_fitote_2019_104443 crossref_primary_10_1007_s12072_019_09970_3 crossref_primary_10_3389_fphar_2020_529553 crossref_primary_10_1002_biof_1556 crossref_primary_10_3389_fimmu_2020_01802 crossref_primary_10_1016_j_foodres_2021_110824 crossref_primary_10_1080_14786419_2024_2316328 crossref_primary_10_1109_TIM_2023_3268480 crossref_primary_10_3390_antiox12051065 crossref_primary_10_1089_jmf_2022_K_0098 crossref_primary_10_1053_j_gastro_2020_06_010 crossref_primary_10_1002_bab_2123 crossref_primary_10_1055_a_1877_9656 crossref_primary_10_1111_apt_15935 crossref_primary_10_1002_hep4_1955 crossref_primary_10_3389_fendo_2023_1160532 crossref_primary_10_1002_hep_31871 crossref_primary_10_3389_fendo_2021_760860 crossref_primary_10_1016_j_phrs_2020_104984 crossref_primary_10_3389_fimmu_2023_1186097 crossref_primary_10_4254_wjh_v13_i7_815 crossref_primary_10_1016_j_heliyon_2024_e33093 crossref_primary_10_3390_nu15041043 crossref_primary_10_1038_s41401_021_00681_w crossref_primary_10_1097_MOG_0000000000000942 crossref_primary_10_3390_ijms21228602 crossref_primary_10_1093_jas_skad059 crossref_primary_10_1016_j_phymed_2024_155712 crossref_primary_10_3748_wjg_v30_i24_3106 crossref_primary_10_1038_s41401_021_00725_1 crossref_primary_10_1073_pnas_2217543120 crossref_primary_10_1155_2022_4246086 crossref_primary_10_1016_j_phymed_2023_154661 crossref_primary_10_1172_jci_insight_140483 crossref_primary_10_3389_fcimb_2021_640448 crossref_primary_10_3390_antiox12040833 crossref_primary_10_3390_cells9010037 crossref_primary_10_1139_apnm_2023_0457 crossref_primary_10_3168_jds_2022_22383 crossref_primary_10_1016_j_bbrc_2020_05_128 crossref_primary_10_1016_j_molmet_2021_101353 crossref_primary_10_1371_journal_pcbi_1009497 crossref_primary_10_3389_fgene_2022_872518 crossref_primary_10_1111_dom_14290 crossref_primary_10_1186_s40816_020_00237_1 crossref_primary_10_1016_j_phymed_2024_155703 crossref_primary_10_3390_ijms24108795 crossref_primary_10_3390_jcm8081098 crossref_primary_10_1016_j_clinsp_2024_100378 crossref_primary_10_3390_nu14071456 crossref_primary_10_1016_j_lfs_2024_122498 crossref_primary_10_3390_ijms231911805 crossref_primary_10_1097_HEP_0000000000000043 crossref_primary_10_7554_eLife_56573 crossref_primary_10_1038_s41598_022_17511_6 crossref_primary_10_1002_jgh3_12790 crossref_primary_10_1038_s41467_020_20303_z crossref_primary_10_3390_nu13020494 crossref_primary_10_1016_j_isci_2022_105802 crossref_primary_10_1038_s41467_023_41145_5 crossref_primary_10_3390_jcm8071057 crossref_primary_10_1038_s41467_021_27539_3 crossref_primary_10_1007_s12013_024_01278_w crossref_primary_10_1097_CM9_0000000000002263 crossref_primary_10_15252_msb_202110459 crossref_primary_10_1016_j_jnutbio_2022_109108 crossref_primary_10_1016_j_jhepr_2023_100694 crossref_primary_10_1016_j_aohep_2024_101285 crossref_primary_10_1016_j_jphotochem_2023_114562
Cites_doi	10.1002/hep.30418 10.1053/gast.2001.23256 10.1056/NEJMoa1712191 10.1002/hep.23315 10.1016/j.jhep.2017.07.027 10.1002/hep.21103 10.1053/j.gastro.2010.09.038 10.1053/j.gastro.2018.07.006 10.1053/j.gastro.2009.06.051 10.1016/j.cgh.2018.04.043 10.1016/S2214-109X(18)30387-5 10.1002/hep.29367 10.1053/j.gastro.2009.04.052 10.1073/pnas.94.6.2557 10.1002/hep.29489 10.1053/j.gastro.2015.04.005 10.1016/S0168-8278(99)80033-6 10.1016/S0140-6736(14)61933-4 10.1002/hep.23133 10.1172/jci.insight.90954 10.1016/j.jhep.2016.05.005 10.1001/jama.2011.520 10.1016/j.cgh.2014.04.014 10.1002/hep.28785 10.1016/S0002-9343(99)00271-5 10.1053/j.gastro.2015.04.043 10.1111/j.1751-2980.2009.00369.x 10.1007/BF02438705 10.1053/j.gastro.2016.01.038 10.1038/nrgastro.2013.175 10.1016/j.jhep.2014.11.034 10.1016/j.cmet.2012.04.004 10.1016/S0168-8278(17)30370-7 10.1002/hep.22742 10.1172/jci.insight.92902 10.1155/2010/362847 10.1185/03007995.2010.506375 10.1053/j.gastro.2013.05.042 10.1053/j.gastro.2007.10.039 10.1002/hep.23270 10.1074/jbc.M116.719955 10.1038/nrgastro.2013.34 10.1111/j.1872-034X.2011.00814.x 10.1016/j.jpeds.2012.08.043 10.1172/JCI8814 10.1002/hep.22569 10.1053/j.gastro.2017.07.024 10.1016/j.cgh.2012.10.001 10.1053/jhep.2002.34738 10.1002/hep.28431 10.1002/hep.1840110114 10.1371/journal.pgen.1001324 10.1002/hep.20842 10.1038/nrgastro.2016.3 10.1002/hep.22724 10.1097/MCG.0000000000000099 10.1016/j.jhep.2018.03.011 10.1016/j.jhep.2006.04.014 10.1038/ng.2901 10.1016/j.cgh.2009.05.033 10.1016/j.jhep.2014.08.036 10.1038/nature06244 10.1016/j.jhep.2017.10.031 10.1111/joim.12719 10.1002/hep.26081 10.1111/j.1572-0241.1999.01377.x 10.1038/nrgastro.2017.38 10.1016/S0016-5085(99)70506-8 10.1053/j.gastro.2014.04.046 10.1111/j.1572-0241.2006.00478.x 10.1194/jlr.R066357 10.1002/hep.29085 10.1042/CS20160838 10.1038/s41598-017-17370-6 10.1016/j.jhep.2009.03.019 10.1053/j.gastro.2016.10.026 10.1093/hmg/ddp236 10.1002/hep.20466 10.1016/S1542-3565(04)00457-4 10.1016/j.jhep.2003.09.020 10.1002/hep.21327 10.1016/j.cct.2016.02.012 10.1016/j.jhep.2007.07.006 10.1053/jhep.2002.30690 10.1038/ng.257 10.1074/jbc.M109.064501 10.1002/hep.27678 10.1002/hep.29359 10.1002/hep.26093 10.1002/hep.26465 10.1053/j.gastro.2009.11.013 10.1042/CS20100387 10.3109/00365521.2011.634024 10.1016/S0016-5085(98)70599-2 10.1038/nature10809 10.15585/mmwr.mm6639e1 10.1016/j.cmet.2017.04.001 10.1152/ajpgi.00365.2011 10.1158/2159-8290.CD-12-0095 10.1016/S0016-5085(03)00907-7 10.1002/hep.29273 10.1002/hep.510230607 10.1056/NEJMra1510062 10.1016/j.cgh.2017.02.030 10.1002/hep.21763 10.1016/0016-5085(89)91513-8 10.1016/j.jhep.2005.07.036 10.1002/hep.23229 10.1056/NEJMoa0907929 10.1016/S0022-3476(00)05040-X 10.1002/hep.29607 10.1111/j.1440-1746.2008.05640.x 10.1111/jgh.12019 10.1136/gutjnl-2017-313958 10.1016/j.cld.2017.08.009 10.1053/j.gastro.2013.06.057 10.1148/radiol.13121360 10.1002/hep.20701 10.1038/oby.2009.379 10.1016/j.jhep.2017.09.024 10.1055/s-0033-1358522 10.1002/hep.26986 10.1002/hep.27173 10.1016/j.jhep.2018.05.036 10.1002/hep.29466
ContentType	Journal Article
Copyright	Springer Nature Limited 2019 Springer Nature Limited 2019.
Copyright_xml	– notice: Springer Nature Limited 2019 – notice: Springer Nature Limited 2019.
DBID	CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88E 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M7P PQEST PQQKQ PQUKI PRINS 7X8
DOI	10.1038/s41575-019-0144-8
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Biological Science Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	ProQuest Central Student MEDLINE
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1759-5053
EndPage	386
ExternalDocumentID	10_1038_s41575_019_0144_8 31024089
Genre	Journal Article Review Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NIH HHS grantid: RO1 DK 105961
GroupedDBID	--- 0R~ 29M 39C 3V. 53G 70F 7X7 88E 8FE 8FH 8FI 8FJ AAEEF AAQQT AARCD AASDW AAWTL AAWYQ AAZLF ABAWZ ABJNI ABLJU ABUWG ABVXF ACGFS ADBBV AENEX AFKRA AFSHS AGAYW AGEZK AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ARMCB AXYYD BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU DB5 EBS EE. EJD EXGXG F5P FQGFK FSGXE FYUFA HCIFZ HMCUK HZ~ IAO IHR IHW INH INR ITC LK8 M1P M7P NNMJJ ODYON OVD PQQKQ PROAC PSQYO RNR RNT RNTTT SHXYY SIXXV SNYQT TAOOD TBHMF TDRGL TEORI TSG UKHRP AAYZH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7XB 8FK AZQEC DWQXO GNUQQ K9. PQEST PQUKI PRINS 7X8
ID	FETCH-LOGICAL-c372t-9f5226febf1973127982044b4a8c6dcaf96363ef9e05085c0bc15773d07e578e3
ISSN	1759-5045
IngestDate	Fri Oct 25 05:31:23 EDT 2024 Thu Oct 10 20:31:29 EDT 2024 Thu Nov 21 21:11:28 EST 2024 Wed Oct 16 00:50:16 EDT 2024 Fri Oct 11 20:48:50 EDT 2024
IsPeerReviewed	true
IsScholarly	true
Issue	6
Language	English
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c372t-9f5226febf1973127982044b4a8c6dcaf96363ef9e05085c0bc15773d07e578e3
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
PMID	31024089
PQID	2231963358
PQPubID	2042741
PageCount	10
ParticipantIDs	proquest_miscellaneous_2216285168 proquest_journals_2231963358 crossref_primary_10_1038_s41575_019_0144_8 pubmed_primary_31024089 springer_journals_10_1038_s41575_019_0144_8
PublicationCentury	2000
PublicationDate	2019-06-01
PublicationDateYYYYMMDD	2019-06-01
PublicationDate_xml	– month: 06 year: 2019 text: 2019-06-01 day: 01
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Nature reviews. Gastroenterology & hepatology
PublicationTitleAbbrev	Nat Rev Gastroenterol Hepatol
PublicationTitleAlternate	Nat Rev Gastroenterol Hepatol
PublicationYear	2019
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Brunt (CR83) 2018 Marchesini (CR20) 1999; 107 BasuRay, Smagris, Cohen, Hobbs (CR54) 2017; 66 Lima-Cabello (CR32) 2011; 120 Asgharpour (CR67) 2016; 65 Puri (CR50) 2009; 50 Yano (CR91) 1996; 23 Min (CR31) 2012; 15 Sanyal (CR84) 2015; 61 Cazanave (CR44) 2017; 7 Angulo (CR79) 2015; 149 Kleiner (CR9) 2005; 41 Dongiovanni (CR82) 2018; 283 Idilman (CR99) 2013; 267 Santhekadur, Kumar, Sanyal (CR61) 2017; 68 Hill-Baskin (CR65) 2009; 18 Miura, Yang, van Rooijen, Ohnishi, Seki (CR41) 2012; 302 Crawford, Powell, Searle, Powell (CR11) 1989; 4 Abul-Husn (CR57) 2018; 378 Steele (CR95) 2017; 66 Miura, Seki, Ohnishi, Brenner (CR38) 2010; 2010 Caldwell (CR22) 1999; 31 Dulai (CR109) 2017; 65 Sanyal, Poklepovic, Moyneur, Barghout (CR92) 2010; 26 Saito (CR64) 2015; 5 Mridha (CR39) 2017; 131 Shah (CR107) 2009; 7 Thaler (CR6) 1962; 335 Day, James (CR16) 1998; 114 Thaler (CR7) 1975; 22 Farrell, Wong, Chitturi (CR4) 2013; 10 Wong, Cheung, Ahmed (CR94) 2014; 59 Mudaliar (CR121) 2013; 145 Maheshwari, Thuluvath (CR13) 2006; 101 Sanyal (CR18) 2010; 362 Sanyal (CR97) 2017; 66 (CR102) 2016; 64 Younossi (CR1) 2016; 64 White, Kanwal, El-Serag (CR93) 2012; 10 Estes, Razavi, Loomba, Younossi, Sanyal (CR2) 2018; 67 Chitturi (CR14) 2002; 36 Cerami (CR128) 2012; 2 Henkel, Green (CR27) 2013; 33 Roh, Seki (CR35) 2013; 28 Sanyal (CR117) 2014; 147 Patel (CR130) 2017; 153 Puri (CR26) 2008; 134 He (CR53) 2010; 285 Everhart (CR76) 2010; 51 Bedossa (CR78) 2014; 60 Feaver (CR45) 2016; 1 Speliotes (CR49) 2011; 7 Ratziu (CR114) 2010; 51 Noureddin (CR72) 2013; 58 Schwimmer (CR73) 2005; 42 Dasarathy (CR119) 2015; 49 Williams (CR71) 2011; 140 Powell (CR10) 1990; 11 McPherson (CR17) 2015; 62 Valenti (CR24) 2010; 138 Rinella, Green (CR63) 2004; 40 Mathurin (CR126) 2009; 137 Rockey (CR104) 2009; 49 (CR70) 2018; 6 Horie, Ohshima, Sato, Suzuki, Watanabe (CR62) 2006; 64 Zhu (CR48) 2013; 57 Ludwig, Viggiano, McGill, Oh (CR8) 1980; 55 Kisseleva (CR40) 2006; 45 Wei, Qiu de, Ma (CR120) 2009; 10 Goodman (CR77) 2007; 47 Hirsova, Ibrahim, Gores, Malhi (CR28) 2016; 57 Hagstrom (CR81) 2017; 67 Rinella, Sanyal (CR103) 2016; 13 Feldstein (CR25) 2003; 125 Romeo (CR52) 2008; 40 Yang, Lin, Lane, Clemens, Diehl (CR15) 1997; 94 Sanyal (CR19) 2001; 120 Castera, Vilgrain, Angulo (CR106) 2013; 10 Younossi (CR3) 2016; 64 Ekstedt (CR89) 2006; 44 Matteoni (CR88) 1999; 116 Argo (CR118) 2015; 62 Africa (CR129) 2018; 16 Welsh, Karpen, Vos (CR69) 2013; 162 Brenner (CR34) 2011; 41 Ratziu (CR86) 2017; 67 Friedman (CR127) 2016; 47 Powell, Searle, Mortimer (CR12) 1989; 97 Ekstedt, Franzen, Mathiesen, Kechagias (CR80) 2012; 47 Ratziu (CR124) 2016; 150 Pagano (CR21) 2002; 35 Siddiqui (CR100) 2018; 17 Turnbaugh (CR58) 2007; 449 Smagris, Gilyard, BasuRay, Cohen, Hobbs (CR56) 2016; 291 Tsuchida (CR66) 2018; 69 Angulo (CR108) 2013; 145 Lavine (CR113) 2000; 136 Harrison (CR87) 2018; 155 Woodcock, LaVange (CR132) 2017; 377 CR125 CR123 Syn (CR46) 2009; 137 Neuschwander-Tetri (CR122) 2015; 385 Cusi (CR116) 2017; 67 Puri (CR29) 2007; 46 Puri, Sanyal (CR60) 2018; 22 Vilar-Gomez (CR133) 2015; 149 Chalasani (CR101) 2017; 67 Brunt, Janney, Di Bisceglie, Neuschwander-Tetri, Bacon (CR75) 1999; 94 Henao-Mejia (CR37) 2012; 482 Itoh (CR42) 2017; 2 Sanyal (CR96) 2006; 43 Nagula, Jain, Groszmann, Garcia-Tsao (CR98) 2006; 44 Miura (CR36) 2013; 57 Argo, Northup, Al-Osaimi, Caldwell (CR85) 2009; 51 Yatsuji (CR105) 2009; 24 Araya (CR30) 2009; 18 Carter-Kent (CR74) 2009; 50 Leclercq (CR23) 2000; 105 Kozlitina (CR55) 2014; 46 Lavine (CR115) 2011; 305 Cheung (CR51) 2008; 48 Sanyal (CR112) 2004; 2 Puri (CR33) 2017; 67 Tsuchida, Friedman (CR47) 2017; 14 Singh (CR90) 2015; 13 Park (CR111) 2017; 152 Browning (CR68) 2004; 40 Brunt (CR43) 2009; 49 Loomba (CR59) 2017; 25 Siddiqui (CR131) 2017; 67 Estes (CR5) 2018; 69 Vuppalanchi (CR110) 2017; 67 JA Africa (144_CR129) 2018; 16 EK Speliotes (144_CR49) 2011; 7 P Hirsova (144_CR28) 2016; 57 P Puri (144_CR29) 2007; 46 ME Rinella (144_CR103) 2016; 13 Y Horie (144_CR62) 2006; 64 AJ Sanyal (144_CR18) 2010; 362 P Bedossa (144_CR78) 2014; 60 AG Shah (144_CR107) 2009; 7 PK Santhekadur (144_CR61) 2017; 68 J Woodcock (144_CR132) 2017; 377 C Estes (144_CR5) 2018; 69 PS Dulai (144_CR109) 2017; 65 J Wei (144_CR120) 2009; 10 AJA Sanyal (144_CR97) 2017; 66 A Maheshwari (144_CR13) 2006; 101 J Henao-Mejia (144_CR37) 2012; 482 AJ Sanyal (144_CR117) 2014; 147 ZM Younossi (144_CR1) 2016; 64 S Nagula (144_CR98) 2006; 44 E Cerami (144_CR128) 2012; 2 AR Mridha (144_CR39) 2017; 131 C Carter-Kent (144_CR74) 2009; 50 S Romeo (144_CR52) 2008; 40 EE Powell (144_CR12) 1989; 97 DA Brenner (144_CR34) 2011; 41 S Yatsuji (144_CR105) 2009; 24 J Kozlitina (144_CR55) 2014; 46 ME Rinella (144_CR63) 2004; 40 P Puri (144_CR60) 2018; 22 IA Leclercq (144_CR23) 2000; 105 H Hagstrom (144_CR81) 2017; 67 CD Williams (144_CR71) 2011; 140 E Lima-Cabello (144_CR32) 2011; 120 P Angulo (144_CR108) 2013; 145 SQ Yang (144_CR15) 1997; 94 AJ Sanyal (144_CR96) 2006; 43 V Ratziu (144_CR124) 2016; 150 V Ratziu (144_CR86) 2017; 67 R Vuppalanchi (144_CR110) 2017; 67 EE Powell (144_CR10) 1990; 11 P Puri (144_CR50) 2009; 50 S McPherson (144_CR17) 2015; 62 A Sanyal (144_CR92) 2010; 26 DC Rockey (144_CR104) 2009; 49 JD Browning (144_CR68) 2004; 40 AJ Sanyal (144_CR112) 2004; 2 A Henkel (144_CR27) 2013; 33 RJ Wong (144_CR94) 2014; 59 CA Matteoni (144_CR88) 1999; 116 S Cazanave (144_CR44) 2017; 7 India State-Level Disease Burden Initiative Diabetes Collaborators (144_CR70) 2018; 6 K Miura (144_CR36) 2013; 57 European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) & European Association for the Study of Obesity (EASO) (144_CR102) 2016; 64 N Chalasani (144_CR101) 2017; 67 J Ludwig (144_CR8) 1980; 55 V Ratziu (144_CR114) 2010; 51 G Marchesini (144_CR20) 1999; 107 DE Kleiner (144_CR9) 2005; 41 WK Syn (144_CR46) 2009; 137 S Singh (144_CR90) 2015; 13 CB Steele (144_CR95) 2017; 66 AE Feldstein (144_CR25) 2003; 125 EM Brunt (144_CR75) 1999; 94 P Dongiovanni (144_CR82) 2018; 283 P Puri (144_CR33) 2017; 67 R Loomba (144_CR59) 2017; 25 E Smagris (144_CR56) 2016; 291 BA Neuschwander-Tetri (144_CR122) 2015; 385 HK Min (144_CR31) 2012; 15 MS Siddiqui (144_CR131) 2017; 67 A Asgharpour (144_CR67) 2016; 65 O Cheung (144_CR51) 2008; 48 JE Lavine (144_CR113) 2000; 136 C Estes (144_CR2) 2018; 67 M Noureddin (144_CR72) 2013; 58 T Kisseleva (144_CR40) 2006; 45 S Mudaliar (144_CR121) 2013; 145 AE Hill-Baskin (144_CR65) 2009; 18 L Zhu (144_CR48) 2013; 57 JE Everhart (144_CR76) 2010; 51 SH Caldwell (144_CR22) 1999; 31 NS Abul-Husn (144_CR57) 2018; 378 GC Farrell (144_CR4) 2013; 10 S BasuRay (144_CR54) 2017; 66 MS Siddiqui (144_CR100) 2018; 17 144_CR123 AJ Sanyal (144_CR84) 2015; 61 144_CR125 S Friedman (144_CR127) 2016; 47 RE Feaver (144_CR45) 2016; 1 H Thaler (144_CR7) 1975; 22 CK Argo (144_CR118) 2015; 62 M Yano (144_CR91) 1996; 23 L Castera (144_CR106) 2013; 10 H Thaler (144_CR6) 1962; 335 P Angulo (144_CR79) 2015; 149 T Tsuchida (144_CR66) 2018; 69 EM Brunt (144_CR43) 2009; 49 CP Day (144_CR16) 1998; 114 J Araya (144_CR30) 2009; 18 YS Roh (144_CR35) 2013; 28 CC Park (144_CR111) 2017; 152 M Ekstedt (144_CR80) 2012; 47 PJ Turnbaugh (144_CR58) 2007; 449 K Saito (144_CR64) 2015; 5 JB Schwimmer (144_CR73) 2005; 42 ZM Younossi (144_CR3) 2016; 64 YA Patel (144_CR130) 2017; 153 K Cusi (144_CR116) 2017; 67 CK Argo (144_CR85) 2009; 51 JE Lavine (144_CR115) 2011; 305 JA Welsh (144_CR69) 2013; 162 S He (144_CR53) 2010; 285 ZD Goodman (144_CR77) 2007; 47 AJ Sanyal (144_CR19) 2001; 120 DL White (144_CR93) 2012; 10 K Miura (144_CR38) 2010; 2010 K Miura (144_CR41) 2012; 302 P Puri (144_CR26) 2008; 134 S Dasarathy (144_CR119) 2015; 49 S Chitturi (144_CR14) 2002; 36 L Valenti (144_CR24) 2010; 138 M Ekstedt (144_CR89) 2006; 44 M Itoh (144_CR42) 2017; 2 G Pagano (144_CR21) 2002; 35 E Vilar-Gomez (144_CR133) 2015; 149 P Mathurin (144_CR126) 2009; 137 IS Idilman (144_CR99) 2013; 267 T Tsuchida (144_CR47) 2017; 14 DH Crawford (144_CR11) 1989; 4 EM Brunt (144_CR83) 2018 SA Harrison (144_CR87) 2018; 155
References_xml	– volume: 285 start-page: 6706 year: 2010 end-page: 6715 ident: CR53 article-title: A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis publication-title: J. Biol. Chem. contributor: fullname: He – volume: 28 start-page: 38 issue: Suppl. 1 year: 2013 end-page: 42 ident: CR35 article-title: Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis publication-title: J. Gastroenterol. Hepatol. contributor: fullname: Seki – volume: 305 start-page: 1659 year: 2011 end-page: 1668 ident: CR115 article-title: Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial publication-title: JAMA contributor: fullname: Lavine – volume: 49 start-page: 809 year: 2009 end-page: 820 ident: CR43 article-title: Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network publication-title: Hepatology contributor: fullname: Brunt – volume: 48 start-page: 1810 year: 2008 end-page: 1820 ident: CR51 article-title: Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression publication-title: Hepatology contributor: fullname: Cheung – volume: 64 start-page: 1033 year: 2006 end-page: 1042 ident: CR62 article-title: Hepatocyte-specific Pten deficient mice [Japanese] publication-title: Nippon Rinsho contributor: fullname: Watanabe – year: 2018 ident: CR83 article-title: Improvements in histologic features and diagnosis associated with improvement in fibrosis in NASH: results from the NASH Clinical Research Network Treatment Trials publication-title: Hepatology doi: 10.1002/hep.30418 contributor: fullname: Brunt – volume: 114 start-page: 842 year: 1998 end-page: 845 ident: CR16 article-title: Steatohepatitis: a tale of two “hits”? publication-title: Gastroenterology contributor: fullname: James – volume: 116 start-page: 1413 year: 1999 end-page: 1419 ident: CR88 article-title: Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity publication-title: Gastroenterology contributor: fullname: Matteoni – volume: 377 start-page: 62 year: 2017 end-page: 70 ident: CR132 article-title: Master protocols to study multiple therapies, multiple diseases, or both publication-title: N. Engl. J. Med. contributor: fullname: LaVange – volume: 94 start-page: 2467 year: 1999 end-page: 2474 ident: CR75 article-title: Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions publication-title: Am. J. Gastroenterol. contributor: fullname: Bacon – volume: 302 start-page: G1310 year: 2012 end-page: G1321 ident: CR41 article-title: Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2 publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. contributor: fullname: Seki – volume: 10 start-page: 85 year: 2009 end-page: 90 ident: CR120 article-title: Bile acids and insulin resistance: implications for treating nonalcoholic fatty liver disease publication-title: J. Dig. Dis. contributor: fullname: Ma – volume: 40 start-page: 1461 year: 2008 end-page: 1465 ident: CR52 article-title: Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease publication-title: Nat. Genet. contributor: fullname: Romeo – volume: 67 start-page: 134 year: 2017 end-page: 144 ident: CR110 article-title: Performance characteristics of vibration-controlled transient elastography for evaluation of non-alcoholic fatty liver disease publication-title: Hepatology contributor: fullname: Vuppalanchi – volume: 138 start-page: 905 year: 2010 end-page: 912 ident: CR24 article-title: HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease publication-title: Gastroenterology contributor: fullname: Valenti – volume: 120 start-page: 1183 year: 2001 end-page: 1192 ident: CR19 article-title: Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities publication-title: Gastroenterology contributor: fullname: Sanyal – volume: 125 start-page: 437 year: 2003 end-page: 443 ident: CR25 article-title: Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis publication-title: Gastroenterology contributor: fullname: Feldstein – volume: 67 start-page: 328 year: 2017 end-page: 357 ident: CR101 article-title: The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases publication-title: Hepatology contributor: fullname: Chalasani – volume: 66 start-page: S54 year: 2017 ident: CR97 article-title: Efficacy and safety of simtuzumab for the treatment of nonalcoholic steatohepatitis with bridging fibrosis or cirrhosis: results of two phase 2b, dose-ranging, randomized, placebo-controlled trials publication-title: J. Hepatol. contributor: fullname: Sanyal – volume: 10 start-page: 1342 year: 2012 end-page: 1359 ident: CR93 article-title: Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review publication-title: Clin. Gastroenterol. Hepatol. contributor: fullname: El-Serag – volume: 131 start-page: 2145 year: 2017 end-page: 2159 ident: CR39 article-title: TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival publication-title: Clin. Sci. contributor: fullname: Mridha – volume: 7 year: 2017 ident: CR44 article-title: The transcriptomic signature of disease development and progression of nonalcoholic fatty liver disease publication-title: Sci. Rep. contributor: fullname: Cazanave – volume: 33 start-page: 321 year: 2013 end-page: 329 ident: CR27 article-title: The unfolded protein response in fatty liver disease publication-title: Semin. Liver Dis. contributor: fullname: Green – volume: 67 start-page: 1371 year: 2017 ident: CR116 article-title: Pioglitazone for the treatment of NASH in patients with prediabetes or type 2 diabetes mellitus publication-title: Gut contributor: fullname: Cusi – volume: 35 start-page: 367 year: 2002 end-page: 372 ident: CR21 article-title: Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association publication-title: Hepatology contributor: fullname: Pagano – volume: 23 start-page: 1334 year: 1996 end-page: 1340 ident: CR91 article-title: The long-term pathological evolution of chronic hepatitis C publication-title: Hepatology contributor: fullname: Yano – volume: 385 start-page: 956 year: 2015 end-page: 965 ident: CR122 article-title: Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial publication-title: Lancet contributor: fullname: Neuschwander-Tetri – volume: 50 start-page: 1113 year: 2009 end-page: 1120 ident: CR74 article-title: Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study publication-title: Hepatology contributor: fullname: Carter-Kent – volume: 149 start-page: 389 year: 2015 end-page: 397 ident: CR79 article-title: Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease publication-title: Gastroenterology contributor: fullname: Angulo – volume: 149 start-page: 367 year: 2015 end-page: 378 ident: CR133 article-title: Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis publication-title: Gastroenterology contributor: fullname: Vilar-Gomez – volume: 362 start-page: 1675 year: 2010 end-page: 1685 ident: CR18 article-title: Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis publication-title: N. Engl. J. Med. contributor: fullname: Sanyal – volume: 152 start-page: 598 year: 2017 end-page: 607 ident: CR111 article-title: Magnetic resonance elastography versus transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease publication-title: Gastroenterology contributor: fullname: Park – volume: 94 start-page: 2557 year: 1997 end-page: 2562 ident: CR15 article-title: Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Diehl – volume: 155 start-page: 1140 year: 2018 end-page: 1153 ident: CR87 article-title: Simtuzumab is ineffective for patients with bridging fibrosis or compensated cirrhosis caused by nonalcoholic steatohepatitis publication-title: Gastroenterology contributor: fullname: Harrison – volume: 50 start-page: 1827 year: 2009 end-page: 1838 ident: CR50 article-title: The plasma lipidomic signature of nonalcoholic steatohepatitis publication-title: Hepatology contributor: fullname: Puri – volume: 18 start-page: 2975 year: 2009 end-page: 2988 ident: CR65 article-title: Diet-induced hepatocellular carcinoma in genetically predisposed mice publication-title: Hum. Mol. Genet. contributor: fullname: Hill-Baskin – volume: 26 start-page: 2183 year: 2010 end-page: 2191 ident: CR92 article-title: Population-based risk factors and resource utilization for HCC: US perspective publication-title: Curr. Med. Res. Opin. contributor: fullname: Barghout – volume: 55 start-page: 434 year: 1980 end-page: 438 ident: CR8 article-title: Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease publication-title: Mayo Clin. Proc. contributor: fullname: Oh – volume: 145 start-page: 574 year: 2013 end-page: 582 ident: CR121 article-title: Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease publication-title: Gastroenterology contributor: fullname: Mudaliar – volume: 22 start-page: 271 year: 1975 end-page: 273 ident: CR7 article-title: Editorial: fatty liver-steatonecrosis-cirrhosis publication-title: Acta Hepatogastroenterol. (Stuttg.) contributor: fullname: Thaler – volume: 36 start-page: 403 year: 2002 end-page: 409 ident: CR14 article-title: Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? publication-title: Hepatology contributor: fullname: Chitturi – volume: 51 start-page: 585 year: 2010 end-page: 594 ident: CR76 article-title: Prognostic value of Ishak fibrosis stage: findings from the hepatitis C antiviral long-term treatment against cirrhosis trial publication-title: Hepatology contributor: fullname: Everhart – volume: 105 start-page: 1067 year: 2000 end-page: 1075 ident: CR23 article-title: CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis publication-title: J. Clin. Invest. contributor: fullname: Leclercq – volume: 65 start-page: 1557 year: 2017 end-page: 1565 ident: CR109 article-title: Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis publication-title: Hepatology contributor: fullname: Dulai – volume: 13 start-page: 196 year: 2016 end-page: 205 ident: CR103 article-title: Management of NAFLD: a stage-based approach publication-title: Nat. Rev. Gastroenterol. Hepatol. contributor: fullname: Sanyal – volume: 67 start-page: 123 year: 2018 end-page: 133 ident: CR2 article-title: Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease publication-title: Hepatology contributor: fullname: Sanyal – volume: 51 start-page: 445 year: 2010 end-page: 453 ident: CR114 article-title: Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial publication-title: Hepatology contributor: fullname: Ratziu – volume: 11 start-page: 74 year: 1990 end-page: 80 ident: CR10 article-title: The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years publication-title: Hepatology contributor: fullname: Powell – volume: 378 start-page: 1096 year: 2018 end-page: 1106 ident: CR57 article-title: A protein-truncating HSD17B13 variant and protection from chronic liver disease publication-title: N. Engl. J. Med. contributor: fullname: Abul-Husn – volume: 44 start-page: 865 year: 2006 end-page: 873 ident: CR89 article-title: Long-term follow-up of patients with NAFLD and elevated liver enzymes publication-title: Hepatology contributor: fullname: Ekstedt – volume: 101 start-page: 664 year: 2006 end-page: 668 ident: CR13 article-title: Cryptogenic cirrhosis and NAFLD: are they related? publication-title: Am. J. Gastroenterol. contributor: fullname: Thuluvath – volume: 57 start-page: 1758 year: 2016 end-page: 1770 ident: CR28 article-title: Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis publication-title: J. Lipid Res. contributor: fullname: Malhi – ident: CR123 – volume: 449 start-page: 804 year: 2007 end-page: 810 ident: CR58 article-title: The human microbiome project publication-title: Nature contributor: fullname: Turnbaugh – volume: 291 start-page: 10659 year: 2016 end-page: 10676 ident: CR56 article-title: Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins publication-title: J. Biol. Chem. contributor: fullname: Hobbs – volume: 6 start-page: e1352 year: 2018 end-page: e1362 ident: CR70 article-title: The increasing burden of diabetes and variations among the states of India: the Global Burden of Disease Study 1990–2016 publication-title: Lancet Glob. Health – volume: 120 start-page: 239 year: 2011 end-page: 250 ident: CR32 article-title: Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C publication-title: Clin. Sci. contributor: fullname: Lima-Cabello – volume: 16 start-page: 438 year: 2018 end-page: 446 ident: CR129 article-title: In children with nonalcoholic fatty liver disease, zone 1 steatosis is associated with advanced fibrosis publication-title: Clin. Gastroenterol. Hepatol. contributor: fullname: Africa – volume: 134 start-page: 568 year: 2008 end-page: 576 ident: CR26 article-title: Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease publication-title: Gastroenterology contributor: fullname: Puri – volume: 68 start-page: 230 year: 2017 end-page: 237 ident: CR61 article-title: Preclinical models of nonalcoholic fatty liver disease publication-title: J. Hepatol. contributor: fullname: Sanyal – volume: 47 start-page: 356 year: 2016 end-page: 365 ident: CR127 article-title: Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR phase 2b study design publication-title: Contemp. Clin. Trials contributor: fullname: Friedman – volume: 64 start-page: 73 year: 2016 end-page: 84 ident: CR1 article-title: Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes publication-title: Hepatology contributor: fullname: Younossi – volume: 137 start-page: 1478 year: 2009 end-page: 1488 ident: CR46 article-title: Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease publication-title: Gastroenterology contributor: fullname: Syn – volume: 64 start-page: 1577 year: 2016 end-page: 1586 ident: CR3 article-title: The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe publication-title: Hepatology contributor: fullname: Younossi – volume: 66 start-page: 1052 year: 2017 end-page: 1058 ident: CR95 article-title: Vital signs: trends in incidence of cancers associated with overweight and obesity - United States, 2005–2014 publication-title: MMWR Morb. Mortal. Wkly Rep. contributor: fullname: Steele – volume: 67 start-page: 2001 year: 2017 end-page: 2012 ident: CR131 article-title: Case definitions for inclusion and analysis of endpoints in clinical trials for NASH through the lens of regulatory science publication-title: Hepatology contributor: fullname: Siddiqui – volume: 45 start-page: 429 year: 2006 end-page: 438 ident: CR40 article-title: Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis publication-title: J. Hepatol. contributor: fullname: Kisseleva – volume: 64 start-page: 1388 year: 2016 end-page: 1402 ident: CR102 article-title: EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease publication-title: J. Hepatol. – volume: 44 start-page: 111 year: 2006 end-page: 117 ident: CR98 article-title: Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis publication-title: J. Hepatol. contributor: fullname: Garcia-Tsao – volume: 62 start-page: 1148 year: 2015 end-page: 1155 ident: CR17 article-title: Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management publication-title: J. Hepatol. contributor: fullname: McPherson – volume: 2010 start-page: 362847 year: 2010 ident: CR38 article-title: Role of toll-like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease publication-title: Gastroenterol. Res. Pract. contributor: fullname: Brenner – volume: 47 start-page: 108 year: 2012 end-page: 115 ident: CR80 article-title: Low clinical relevance of the nonalcoholic fatty liver disease activity score (NAS) in predicting fibrosis progression publication-title: Scand. J. Gastroenterol. contributor: fullname: Kechagias – volume: 40 start-page: 47 year: 2004 end-page: 51 ident: CR63 article-title: The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance publication-title: J. Hepatol. contributor: fullname: Green – volume: 58 start-page: 1644 year: 2013 end-page: 1654 ident: CR72 article-title: Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients publication-title: Hepatology contributor: fullname: Noureddin – ident: CR125 – volume: 2 start-page: 401 year: 2012 end-page: 404 ident: CR128 article-title: The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data publication-title: Cancer Discov. contributor: fullname: Cerami – volume: 46 start-page: 1081 year: 2007 end-page: 1090 ident: CR29 article-title: A lipidomic analysis of nonalcoholic fatty liver disease publication-title: Hepatology contributor: fullname: Puri – volume: 60 start-page: 565 year: 2014 end-page: 575 ident: CR78 article-title: Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease publication-title: Hepatology contributor: fullname: Bedossa – volume: 153 start-page: 621 year: 2017 end-page: 625 ident: CR130 article-title: Baseline parameters in clinical trials for nonalcoholic steatohepatitis: recommendations from the Liver Forum publication-title: Gastroenterology contributor: fullname: Patel – volume: 335 start-page: 180 year: 1962 end-page: 210 ident: CR6 article-title: The fatty liver and its pathogenetic relation to liver cirrhosis [German] publication-title: Virchows Arch. Pathol. Anat. Physiol. Klin. Med. contributor: fullname: Thaler – volume: 15 start-page: 665 year: 2012 end-page: 674 ident: CR31 article-title: Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease publication-title: Cell Metab. contributor: fullname: Min – volume: 67 start-page: 534 year: 2017 end-page: 548 ident: CR33 article-title: The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids publication-title: Hepatology contributor: fullname: Puri – volume: 49 start-page: 1017 year: 2009 end-page: 1044 ident: CR104 article-title: Liver biopsy publication-title: Hepatology contributor: fullname: Rockey – volume: 69 start-page: 896 year: 2018 end-page: 904 ident: CR5 article-title: Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030 publication-title: J. Hepatol. contributor: fullname: Estes – volume: 69 start-page: 385 year: 2018 end-page: 395 ident: CR66 article-title: A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer publication-title: J. Hepatol. contributor: fullname: Tsuchida – volume: 41 start-page: 683 year: 2011 end-page: 686 ident: CR34 article-title: Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase publication-title: Hepatol. Res. contributor: fullname: Brenner – volume: 1 year: 2016 ident: CR45 article-title: Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis publication-title: JCI Insight contributor: fullname: Feaver – volume: 267 start-page: 767 year: 2013 end-page: 775 ident: CR99 article-title: Hepatic steatosis: quantification by proton density fat fraction with MR imaging versus liver biopsy publication-title: Radiology contributor: fullname: Idilman – volume: 17 start-page: 156 year: 2018 end-page: 163 ident: CR100 article-title: Vibration-controlled transient elastography to assess fibrosis and steatosis in patients with nonalcoholic fatty liver disease publication-title: Clin. Gastroenterol. Hepatol. contributor: fullname: Siddiqui – volume: 31 start-page: 430 year: 1999 end-page: 434 ident: CR22 article-title: Mitochondrial abnormalities in non-alcoholic steatohepatitis publication-title: J. Hepatol. contributor: fullname: Caldwell – volume: 42 start-page: 641 year: 2005 end-page: 649 ident: CR73 article-title: Histopathology of pediatric nonalcoholic fatty liver disease publication-title: Hepatology contributor: fullname: Schwimmer – volume: 67 start-page: 1134 year: 2017 end-page: 1136 ident: CR86 article-title: Back to Byzance: Querelles byzantines over NASH and fibrosis publication-title: J. Hepatol. contributor: fullname: Ratziu – volume: 65 start-page: 579 year: 2016 end-page: 588 ident: CR67 article-title: A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer publication-title: J. Hepatol. contributor: fullname: Asgharpour – volume: 2 start-page: 1107 year: 2004 end-page: 1115 ident: CR112 article-title: A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis publication-title: Clin. Gastroenterol. Hepatol. contributor: fullname: Sanyal – volume: 18 start-page: 1460 year: 2009 end-page: 1463 ident: CR30 article-title: Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients publication-title: Obesity (Silver Spring) contributor: fullname: Araya – volume: 41 start-page: 1313 year: 2005 end-page: 1321 ident: CR9 article-title: Design and validation of a histological scoring system for nonalcoholic fatty liver disease publication-title: Hepatology contributor: fullname: Kleiner – volume: 46 start-page: 352 year: 2014 end-page: 356 ident: CR55 article-title: Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease publication-title: Nat. Genet. contributor: fullname: Kozlitina – volume: 49 start-page: 137 year: 2015 end-page: 144 ident: CR119 article-title: Double-blind randomized placebo-controlled clinical trial of omega 3 fatty acids for the treatment of diabetic patients with nonalcoholic steatohepatitis publication-title: J. Clin. Gastroenterol. contributor: fullname: Dasarathy – volume: 2 start-page: 92902 year: 2017 ident: CR42 article-title: CD11c resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis publication-title: JCI Insight contributor: fullname: Itoh – volume: 59 start-page: 2188 year: 2014 end-page: 2195 ident: CR94 article-title: Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S publication-title: Hepatology contributor: fullname: Ahmed – volume: 107 start-page: 450 year: 1999 end-page: 455 ident: CR20 article-title: Association of nonalcoholic fatty liver disease with insulin resistance publication-title: Am. J. Med. contributor: fullname: Marchesini – volume: 162 start-page: 496 year: 2013 end-page: 500 ident: CR69 article-title: Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988–1994 to 2007–2010 publication-title: J. Pediatr. contributor: fullname: Vos – volume: 482 start-page: 179 year: 2012 end-page: 185 ident: CR37 article-title: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity publication-title: Nature contributor: fullname: Henao-Mejia – volume: 66 start-page: 1111 year: 2017 end-page: 1124 ident: CR54 article-title: The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation publication-title: Hepatology contributor: fullname: Hobbs – volume: 140 start-page: 124 year: 2011 end-page: 131 ident: CR71 article-title: Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study publication-title: Gastroenterology contributor: fullname: Williams – volume: 14 start-page: 397 year: 2017 end-page: 411 ident: CR47 article-title: Mechanisms of hepatic stellate cell activation publication-title: Nat. Rev. Gastroenterol. Hepatol. contributor: fullname: Friedman – volume: 40 start-page: 1387 year: 2004 end-page: 1395 ident: CR68 article-title: Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity publication-title: Hepatology contributor: fullname: Browning – volume: 7 year: 2011 ident: CR49 article-title: Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits publication-title: PLOS Genet. contributor: fullname: Speliotes – volume: 67 start-page: 1265 year: 2017 end-page: 1273 ident: CR81 article-title: Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD publication-title: J. Hepatol. contributor: fullname: Hagstrom – volume: 25 start-page: 1054 year: 2017 end-page: 1062 ident: CR59 article-title: Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease publication-title: Cell Metab. contributor: fullname: Loomba – volume: 97 start-page: 1022 year: 1989 end-page: 1024 ident: CR12 article-title: Steatohepatitis associated with limb lipodystrophy publication-title: Gastroenterology contributor: fullname: Mortimer – volume: 10 start-page: 666 year: 2013 end-page: 675 ident: CR106 article-title: Noninvasive evaluation of NAFLD publication-title: Nat. Rev. Gastroenterol. Hepatol. contributor: fullname: Angulo – volume: 145 start-page: 782 year: 2013 end-page: 789 ident: CR108 article-title: Simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease publication-title: Gastroenterology contributor: fullname: Angulo – volume: 150 start-page: 1147 year: 2016 end-page: 1159 ident: CR124 article-title: Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening publication-title: Gastroenterology contributor: fullname: Ratziu – volume: 137 start-page: 532 year: 2009 end-page: 540 ident: CR126 article-title: Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease publication-title: Gastroenterology contributor: fullname: Mathurin – volume: 22 start-page: 121 year: 2018 end-page: 132 ident: CR60 article-title: The intestinal microbiome in nonalcoholic fatty liver disease publication-title: Clin. Liver Dis. contributor: fullname: Sanyal – volume: 43 start-page: 682 year: 2006 end-page: 689 ident: CR96 article-title: Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C publication-title: Hepatology contributor: fullname: Sanyal – volume: 62 start-page: 190 year: 2015 end-page: 197 ident: CR118 article-title: Effects of n-3 fish oil on metabolic and histological parameters in NASH: a double-blind, randomized, placebo-controlled trial publication-title: J. Hepatol. contributor: fullname: Argo – volume: 57 start-page: 601 year: 2013 end-page: 609 ident: CR48 article-title: Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH publication-title: Hepatology contributor: fullname: Zhu – volume: 13 start-page: 643 year: 2015 end-page: 654 ident: CR90 article-title: Fibrosis progression in nonalcoholic fatty liver versus nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies publication-title: Clin. Gastroenterol. Hepatol. contributor: fullname: Singh – volume: 10 start-page: 307 year: 2013 end-page: 318 ident: CR4 article-title: NAFLD in Asia—as common and important as in the West publication-title: Nat. Rev. Gastroenterol. Hepatol. contributor: fullname: Chitturi – volume: 7 start-page: 1104 year: 2009 end-page: 1112 ident: CR107 article-title: Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease publication-title: Clin. Gastroenterol. Hepatol. contributor: fullname: Shah – volume: 5 year: 2015 ident: CR64 article-title: Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis publication-title: Sci. Rep. contributor: fullname: Saito – volume: 61 start-page: 1392 year: 2015 end-page: 1405 ident: CR84 article-title: Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop publication-title: Hepatology contributor: fullname: Sanyal – volume: 147 start-page: 377 year: 2014 end-page: 384 ident: CR117 article-title: No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial publication-title: Gastroenterology contributor: fullname: Sanyal – volume: 51 start-page: 371 year: 2009 end-page: 379 ident: CR85 article-title: Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis publication-title: J. Hepatol. contributor: fullname: Caldwell – volume: 57 start-page: 577 year: 2013 end-page: 589 ident: CR36 article-title: Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice publication-title: Hepatology contributor: fullname: Miura – volume: 4 start-page: 36 issue: Suppl. 1 year: 1989 end-page: 38 ident: CR11 article-title: Steatohepatitis: comparison of alcoholic and non-alcoholic subjects with particular reference to portal hypertension and hepatic complications publication-title: J. Gastroenterol. Hepatol. contributor: fullname: Powell – volume: 47 start-page: 598 year: 2007 end-page: 607 ident: CR77 article-title: Grading and staging systems for inflammation and fibrosis in chronic liver diseases publication-title: J. Hepatol. contributor: fullname: Goodman – volume: 283 start-page: 356 year: 2018 end-page: 370 ident: CR82 article-title: Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver publication-title: J. Intern. Med. contributor: fullname: Dongiovanni – volume: 136 start-page: 734 year: 2000 end-page: 738 ident: CR113 article-title: Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study publication-title: J. Pediatr. contributor: fullname: Lavine – volume: 24 start-page: 248 year: 2009 end-page: 254 ident: CR105 article-title: Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C publication-title: J. Gastroenterol. Hepatol. contributor: fullname: Yatsuji – volume: 120 start-page: 1183 year: 2001 ident: 144_CR19 publication-title: Gastroenterology doi: 10.1053/gast.2001.23256 contributor: fullname: AJ Sanyal – volume: 378 start-page: 1096 year: 2018 ident: 144_CR57 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1712191 contributor: fullname: NS Abul-Husn – volume: 51 start-page: 585 year: 2010 ident: 144_CR76 publication-title: Hepatology doi: 10.1002/hep.23315 contributor: fullname: JE Everhart – volume: 67 start-page: 1265 year: 2017 ident: 144_CR81 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2017.07.027 contributor: fullname: H Hagstrom – volume: 43 start-page: 682 year: 2006 ident: 144_CR96 publication-title: Hepatology doi: 10.1002/hep.21103 contributor: fullname: AJ Sanyal – volume: 140 start-page: 124 year: 2011 ident: 144_CR71 publication-title: Gastroenterology doi: 10.1053/j.gastro.2010.09.038 contributor: fullname: CD Williams – volume: 155 start-page: 1140 year: 2018 ident: 144_CR87 publication-title: Gastroenterology doi: 10.1053/j.gastro.2018.07.006 contributor: fullname: SA Harrison – volume: 137 start-page: 1478 year: 2009 ident: 144_CR46 publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.06.051 contributor: fullname: WK Syn – volume: 17 start-page: 156 year: 2018 ident: 144_CR100 publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/j.cgh.2018.04.043 contributor: fullname: MS Siddiqui – volume: 6 start-page: e1352 year: 2018 ident: 144_CR70 publication-title: Lancet Glob. Health doi: 10.1016/S2214-109X(18)30387-5 contributor: fullname: India State-Level Disease Burden Initiative Diabetes Collaborators – volume: 67 start-page: 328 year: 2017 ident: 144_CR101 publication-title: Hepatology doi: 10.1002/hep.29367 contributor: fullname: N Chalasani – volume: 137 start-page: 532 year: 2009 ident: 144_CR126 publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.04.052 contributor: fullname: P Mathurin – volume: 94 start-page: 2557 year: 1997 ident: 144_CR15 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.94.6.2557 contributor: fullname: SQ Yang – volume: 67 start-page: 134 year: 2017 ident: 144_CR110 publication-title: Hepatology doi: 10.1002/hep.29489 contributor: fullname: R Vuppalanchi – volume: 149 start-page: 367 year: 2015 ident: 144_CR133 publication-title: Gastroenterology doi: 10.1053/j.gastro.2015.04.005 contributor: fullname: E Vilar-Gomez – volume: 55 start-page: 434 year: 1980 ident: 144_CR8 publication-title: Mayo Clin. Proc. contributor: fullname: J Ludwig – volume: 31 start-page: 430 year: 1999 ident: 144_CR22 publication-title: J. Hepatol. doi: 10.1016/S0168-8278(99)80033-6 contributor: fullname: SH Caldwell – volume: 385 start-page: 956 year: 2015 ident: 144_CR122 publication-title: Lancet doi: 10.1016/S0140-6736(14)61933-4 contributor: fullname: BA Neuschwander-Tetri – volume: 50 start-page: 1113 year: 2009 ident: 144_CR74 publication-title: Hepatology doi: 10.1002/hep.23133 contributor: fullname: C Carter-Kent – volume: 1 year: 2016 ident: 144_CR45 publication-title: JCI Insight doi: 10.1172/jci.insight.90954 contributor: fullname: RE Feaver – volume: 65 start-page: 579 year: 2016 ident: 144_CR67 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2016.05.005 contributor: fullname: A Asgharpour – ident: 144_CR123 – volume: 305 start-page: 1659 year: 2011 ident: 144_CR115 publication-title: JAMA doi: 10.1001/jama.2011.520 contributor: fullname: JE Lavine – volume: 13 start-page: 643 year: 2015 ident: 144_CR90 publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/j.cgh.2014.04.014 contributor: fullname: S Singh – volume: 64 start-page: 1577 year: 2016 ident: 144_CR3 publication-title: Hepatology doi: 10.1002/hep.28785 contributor: fullname: ZM Younossi – volume: 107 start-page: 450 year: 1999 ident: 144_CR20 publication-title: Am. J. Med. doi: 10.1016/S0002-9343(99)00271-5 contributor: fullname: G Marchesini – volume: 149 start-page: 389 year: 2015 ident: 144_CR79 publication-title: Gastroenterology doi: 10.1053/j.gastro.2015.04.043 contributor: fullname: P Angulo – volume: 10 start-page: 85 year: 2009 ident: 144_CR120 publication-title: J. Dig. Dis. doi: 10.1111/j.1751-2980.2009.00369.x contributor: fullname: J Wei – volume: 335 start-page: 180 year: 1962 ident: 144_CR6 publication-title: Virchows Arch. Pathol. Anat. Physiol. Klin. Med. doi: 10.1007/BF02438705 contributor: fullname: H Thaler – volume: 150 start-page: 1147 year: 2016 ident: 144_CR124 publication-title: Gastroenterology doi: 10.1053/j.gastro.2016.01.038 contributor: fullname: V Ratziu – volume: 10 start-page: 666 year: 2013 ident: 144_CR106 publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2013.175 contributor: fullname: L Castera – volume: 62 start-page: 1148 year: 2015 ident: 144_CR17 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2014.11.034 contributor: fullname: S McPherson – volume: 15 start-page: 665 year: 2012 ident: 144_CR31 publication-title: Cell Metab. doi: 10.1016/j.cmet.2012.04.004 contributor: fullname: HK Min – volume: 66 start-page: S54 year: 2017 ident: 144_CR97 publication-title: J. Hepatol. doi: 10.1016/S0168-8278(17)30370-7 contributor: fullname: AJA Sanyal – volume: 49 start-page: 1017 year: 2009 ident: 144_CR104 publication-title: Hepatology doi: 10.1002/hep.22742 contributor: fullname: DC Rockey – volume: 2 start-page: 92902 year: 2017 ident: 144_CR42 publication-title: JCI Insight doi: 10.1172/jci.insight.92902 contributor: fullname: M Itoh – volume: 2010 start-page: 362847 year: 2010 ident: 144_CR38 publication-title: Gastroenterol. Res. Pract. doi: 10.1155/2010/362847 contributor: fullname: K Miura – volume: 26 start-page: 2183 year: 2010 ident: 144_CR92 publication-title: Curr. Med. Res. Opin. doi: 10.1185/03007995.2010.506375 contributor: fullname: A Sanyal – volume: 145 start-page: 574 year: 2013 ident: 144_CR121 publication-title: Gastroenterology doi: 10.1053/j.gastro.2013.05.042 contributor: fullname: S Mudaliar – volume: 134 start-page: 568 year: 2008 ident: 144_CR26 publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.10.039 contributor: fullname: P Puri – volume: 51 start-page: 445 year: 2010 ident: 144_CR114 publication-title: Hepatology doi: 10.1002/hep.23270 contributor: fullname: V Ratziu – volume: 291 start-page: 10659 year: 2016 ident: 144_CR56 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M116.719955 contributor: fullname: E Smagris – volume: 10 start-page: 307 year: 2013 ident: 144_CR4 publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2013.34 contributor: fullname: GC Farrell – volume: 41 start-page: 683 year: 2011 ident: 144_CR34 publication-title: Hepatol. Res. doi: 10.1111/j.1872-034X.2011.00814.x contributor: fullname: DA Brenner – volume: 162 start-page: 496 year: 2013 ident: 144_CR69 publication-title: J. Pediatr. doi: 10.1016/j.jpeds.2012.08.043 contributor: fullname: JA Welsh – volume: 105 start-page: 1067 year: 2000 ident: 144_CR23 publication-title: J. Clin. Invest. doi: 10.1172/JCI8814 contributor: fullname: IA Leclercq – volume: 48 start-page: 1810 year: 2008 ident: 144_CR51 publication-title: Hepatology doi: 10.1002/hep.22569 contributor: fullname: O Cheung – volume: 153 start-page: 621 year: 2017 ident: 144_CR130 publication-title: Gastroenterology doi: 10.1053/j.gastro.2017.07.024 contributor: fullname: YA Patel – volume: 10 start-page: 1342 year: 2012 ident: 144_CR93 publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/j.cgh.2012.10.001 contributor: fullname: DL White – volume: 36 start-page: 403 year: 2002 ident: 144_CR14 publication-title: Hepatology doi: 10.1053/jhep.2002.34738 contributor: fullname: S Chitturi – volume: 64 start-page: 73 year: 2016 ident: 144_CR1 publication-title: Hepatology doi: 10.1002/hep.28431 contributor: fullname: ZM Younossi – volume: 11 start-page: 74 year: 1990 ident: 144_CR10 publication-title: Hepatology doi: 10.1002/hep.1840110114 contributor: fullname: EE Powell – volume: 7 year: 2011 ident: 144_CR49 publication-title: PLOS Genet. doi: 10.1371/journal.pgen.1001324 contributor: fullname: EK Speliotes – volume: 42 start-page: 641 year: 2005 ident: 144_CR73 publication-title: Hepatology doi: 10.1002/hep.20842 contributor: fullname: JB Schwimmer – volume: 13 start-page: 196 year: 2016 ident: 144_CR103 publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2016.3 contributor: fullname: ME Rinella – volume: 49 start-page: 809 year: 2009 ident: 144_CR43 publication-title: Hepatology doi: 10.1002/hep.22724 contributor: fullname: EM Brunt – volume: 49 start-page: 137 year: 2015 ident: 144_CR119 publication-title: J. Clin. Gastroenterol. doi: 10.1097/MCG.0000000000000099 contributor: fullname: S Dasarathy – volume: 69 start-page: 385 year: 2018 ident: 144_CR66 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2018.03.011 contributor: fullname: T Tsuchida – volume: 45 start-page: 429 year: 2006 ident: 144_CR40 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2006.04.014 contributor: fullname: T Kisseleva – volume: 46 start-page: 352 year: 2014 ident: 144_CR55 publication-title: Nat. Genet. doi: 10.1038/ng.2901 contributor: fullname: J Kozlitina – volume: 7 start-page: 1104 year: 2009 ident: 144_CR107 publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/j.cgh.2009.05.033 contributor: fullname: AG Shah – volume: 4 start-page: 36 issue: Suppl. 1 year: 1989 ident: 144_CR11 publication-title: J. Gastroenterol. Hepatol. contributor: fullname: DH Crawford – volume: 62 start-page: 190 year: 2015 ident: 144_CR118 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2014.08.036 contributor: fullname: CK Argo – volume: 449 start-page: 804 year: 2007 ident: 144_CR58 publication-title: Nature doi: 10.1038/nature06244 contributor: fullname: PJ Turnbaugh – volume: 68 start-page: 230 year: 2017 ident: 144_CR61 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2017.10.031 contributor: fullname: PK Santhekadur – volume: 283 start-page: 356 year: 2018 ident: 144_CR82 publication-title: J. Intern. Med. doi: 10.1111/joim.12719 contributor: fullname: P Dongiovanni – volume: 57 start-page: 577 year: 2013 ident: 144_CR36 publication-title: Hepatology doi: 10.1002/hep.26081 contributor: fullname: K Miura – volume: 94 start-page: 2467 year: 1999 ident: 144_CR75 publication-title: Am. J. Gastroenterol. doi: 10.1111/j.1572-0241.1999.01377.x contributor: fullname: EM Brunt – volume: 64 start-page: 1388 year: 2016 ident: 144_CR102 publication-title: J. Hepatol. contributor: fullname: European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) & European Association for the Study of Obesity (EASO) – volume: 14 start-page: 397 year: 2017 ident: 144_CR47 publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2017.38 contributor: fullname: T Tsuchida – volume: 116 start-page: 1413 year: 1999 ident: 144_CR88 publication-title: Gastroenterology doi: 10.1016/S0016-5085(99)70506-8 contributor: fullname: CA Matteoni – volume: 147 start-page: 377 year: 2014 ident: 144_CR117 publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.04.046 contributor: fullname: AJ Sanyal – volume: 64 start-page: 1033 year: 2006 ident: 144_CR62 publication-title: Nippon Rinsho contributor: fullname: Y Horie – volume: 101 start-page: 664 year: 2006 ident: 144_CR13 publication-title: Am. J. Gastroenterol. doi: 10.1111/j.1572-0241.2006.00478.x contributor: fullname: A Maheshwari – volume: 57 start-page: 1758 year: 2016 ident: 144_CR28 publication-title: J. Lipid Res. doi: 10.1194/jlr.R066357 contributor: fullname: P Hirsova – volume: 5 year: 2015 ident: 144_CR64 publication-title: Sci. Rep. contributor: fullname: K Saito – volume: 65 start-page: 1557 year: 2017 ident: 144_CR109 publication-title: Hepatology doi: 10.1002/hep.29085 contributor: fullname: PS Dulai – volume: 131 start-page: 2145 year: 2017 ident: 144_CR39 publication-title: Clin. Sci. doi: 10.1042/CS20160838 contributor: fullname: AR Mridha – volume: 7 year: 2017 ident: 144_CR44 publication-title: Sci. Rep. doi: 10.1038/s41598-017-17370-6 contributor: fullname: S Cazanave – ident: 144_CR125 – volume: 51 start-page: 371 year: 2009 ident: 144_CR85 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2009.03.019 contributor: fullname: CK Argo – volume: 152 start-page: 598 year: 2017 ident: 144_CR111 publication-title: Gastroenterology doi: 10.1053/j.gastro.2016.10.026 contributor: fullname: CC Park – volume: 18 start-page: 2975 year: 2009 ident: 144_CR65 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddp236 contributor: fullname: AE Hill-Baskin – volume: 40 start-page: 1387 year: 2004 ident: 144_CR68 publication-title: Hepatology doi: 10.1002/hep.20466 contributor: fullname: JD Browning – volume: 2 start-page: 1107 year: 2004 ident: 144_CR112 publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/S1542-3565(04)00457-4 contributor: fullname: AJ Sanyal – volume: 40 start-page: 47 year: 2004 ident: 144_CR63 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2003.09.020 contributor: fullname: ME Rinella – volume: 44 start-page: 865 year: 2006 ident: 144_CR89 publication-title: Hepatology doi: 10.1002/hep.21327 contributor: fullname: M Ekstedt – volume: 47 start-page: 356 year: 2016 ident: 144_CR127 publication-title: Contemp. Clin. Trials doi: 10.1016/j.cct.2016.02.012 contributor: fullname: S Friedman – volume: 47 start-page: 598 year: 2007 ident: 144_CR77 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2007.07.006 contributor: fullname: ZD Goodman – volume: 35 start-page: 367 year: 2002 ident: 144_CR21 publication-title: Hepatology doi: 10.1053/jhep.2002.30690 contributor: fullname: G Pagano – volume: 40 start-page: 1461 year: 2008 ident: 144_CR52 publication-title: Nat. Genet. doi: 10.1038/ng.257 contributor: fullname: S Romeo – volume: 285 start-page: 6706 year: 2010 ident: 144_CR53 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.064501 contributor: fullname: S He – volume: 61 start-page: 1392 year: 2015 ident: 144_CR84 publication-title: Hepatology doi: 10.1002/hep.27678 contributor: fullname: AJ Sanyal – volume: 67 start-page: 534 year: 2017 ident: 144_CR33 publication-title: Hepatology doi: 10.1002/hep.29359 contributor: fullname: P Puri – volume: 57 start-page: 601 year: 2013 ident: 144_CR48 publication-title: Hepatology doi: 10.1002/hep.26093 contributor: fullname: L Zhu – volume: 58 start-page: 1644 year: 2013 ident: 144_CR72 publication-title: Hepatology doi: 10.1002/hep.26465 contributor: fullname: M Noureddin – volume: 138 start-page: 905 year: 2010 ident: 144_CR24 publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.11.013 contributor: fullname: L Valenti – volume: 120 start-page: 239 year: 2011 ident: 144_CR32 publication-title: Clin. Sci. doi: 10.1042/CS20100387 contributor: fullname: E Lima-Cabello – volume: 47 start-page: 108 year: 2012 ident: 144_CR80 publication-title: Scand. J. Gastroenterol. doi: 10.3109/00365521.2011.634024 contributor: fullname: M Ekstedt – volume: 114 start-page: 842 year: 1998 ident: 144_CR16 publication-title: Gastroenterology doi: 10.1016/S0016-5085(98)70599-2 contributor: fullname: CP Day – volume: 22 start-page: 271 year: 1975 ident: 144_CR7 publication-title: Acta Hepatogastroenterol. (Stuttg.) contributor: fullname: H Thaler – volume: 482 start-page: 179 year: 2012 ident: 144_CR37 publication-title: Nature doi: 10.1038/nature10809 contributor: fullname: J Henao-Mejia – volume: 66 start-page: 1052 year: 2017 ident: 144_CR95 publication-title: MMWR Morb. Mortal. Wkly Rep. doi: 10.15585/mmwr.mm6639e1 contributor: fullname: CB Steele – volume: 25 start-page: 1054 year: 2017 ident: 144_CR59 publication-title: Cell Metab. doi: 10.1016/j.cmet.2017.04.001 contributor: fullname: R Loomba – volume: 302 start-page: G1310 year: 2012 ident: 144_CR41 publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. doi: 10.1152/ajpgi.00365.2011 contributor: fullname: K Miura – volume: 2 start-page: 401 year: 2012 ident: 144_CR128 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-12-0095 contributor: fullname: E Cerami – volume: 125 start-page: 437 year: 2003 ident: 144_CR25 publication-title: Gastroenterology doi: 10.1016/S0016-5085(03)00907-7 contributor: fullname: AE Feldstein – volume: 66 start-page: 1111 year: 2017 ident: 144_CR54 publication-title: Hepatology doi: 10.1002/hep.29273 contributor: fullname: S BasuRay – volume: 23 start-page: 1334 year: 1996 ident: 144_CR91 publication-title: Hepatology doi: 10.1002/hep.510230607 contributor: fullname: M Yano – volume: 377 start-page: 62 year: 2017 ident: 144_CR132 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1510062 contributor: fullname: J Woodcock – volume: 16 start-page: 438 year: 2018 ident: 144_CR129 publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/j.cgh.2017.02.030 contributor: fullname: JA Africa – volume: 46 start-page: 1081 year: 2007 ident: 144_CR29 publication-title: Hepatology doi: 10.1002/hep.21763 contributor: fullname: P Puri – volume: 97 start-page: 1022 year: 1989 ident: 144_CR12 publication-title: Gastroenterology doi: 10.1016/0016-5085(89)91513-8 contributor: fullname: EE Powell – volume: 44 start-page: 111 year: 2006 ident: 144_CR98 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2005.07.036 contributor: fullname: S Nagula – volume: 50 start-page: 1827 year: 2009 ident: 144_CR50 publication-title: Hepatology doi: 10.1002/hep.23229 contributor: fullname: P Puri – volume: 362 start-page: 1675 year: 2010 ident: 144_CR18 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0907929 contributor: fullname: AJ Sanyal – volume: 136 start-page: 734 year: 2000 ident: 144_CR113 publication-title: J. Pediatr. doi: 10.1016/S0022-3476(00)05040-X contributor: fullname: JE Lavine – volume: 67 start-page: 2001 year: 2017 ident: 144_CR131 publication-title: Hepatology doi: 10.1002/hep.29607 contributor: fullname: MS Siddiqui – volume: 24 start-page: 248 year: 2009 ident: 144_CR105 publication-title: J. Gastroenterol. Hepatol. doi: 10.1111/j.1440-1746.2008.05640.x contributor: fullname: S Yatsuji – volume: 28 start-page: 38 issue: Suppl. 1 year: 2013 ident: 144_CR35 publication-title: J. Gastroenterol. Hepatol. doi: 10.1111/jgh.12019 contributor: fullname: YS Roh – year: 2018 ident: 144_CR83 publication-title: Hepatology doi: 10.1002/hep.30418 contributor: fullname: EM Brunt – volume: 67 start-page: 1371 year: 2017 ident: 144_CR116 publication-title: Gut doi: 10.1136/gutjnl-2017-313958 contributor: fullname: K Cusi – volume: 22 start-page: 121 year: 2018 ident: 144_CR60 publication-title: Clin. Liver Dis. doi: 10.1016/j.cld.2017.08.009 contributor: fullname: P Puri – volume: 145 start-page: 782 year: 2013 ident: 144_CR108 publication-title: Gastroenterology doi: 10.1053/j.gastro.2013.06.057 contributor: fullname: P Angulo – volume: 267 start-page: 767 year: 2013 ident: 144_CR99 publication-title: Radiology doi: 10.1148/radiol.13121360 contributor: fullname: IS Idilman – volume: 41 start-page: 1313 year: 2005 ident: 144_CR9 publication-title: Hepatology doi: 10.1002/hep.20701 contributor: fullname: DE Kleiner – volume: 18 start-page: 1460 year: 2009 ident: 144_CR30 publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2009.379 contributor: fullname: J Araya – volume: 67 start-page: 1134 year: 2017 ident: 144_CR86 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2017.09.024 contributor: fullname: V Ratziu – volume: 33 start-page: 321 year: 2013 ident: 144_CR27 publication-title: Semin. Liver Dis. doi: 10.1055/s-0033-1358522 contributor: fullname: A Henkel – volume: 59 start-page: 2188 year: 2014 ident: 144_CR94 publication-title: Hepatology doi: 10.1002/hep.26986 contributor: fullname: RJ Wong – volume: 60 start-page: 565 year: 2014 ident: 144_CR78 publication-title: Hepatology doi: 10.1002/hep.27173 contributor: fullname: P Bedossa – volume: 69 start-page: 896 year: 2018 ident: 144_CR5 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2018.05.036 contributor: fullname: C Estes – volume: 67 start-page: 123 year: 2018 ident: 144_CR2 publication-title: Hepatology doi: 10.1002/hep.29466 contributor: fullname: C Estes
SSID	ssj0065539
Score	2.702119
SecondaryResourceType	review_article
Snippet	Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four decades ago. However, the condition has become the centre of...
SourceID	proquest crossref pubmed springer
SourceType	Aggregation Database Index Database Publisher
StartPage	377
SubjectTerms	692/4020/1503/1607/2750 692/4020/2741/288 692/4020/4021/1607/2751 Alcohol use Biomedicine Disease Progression End Stage Liver Disease - epidemiology End Stage Liver Disease - etiology Fatty liver Gastroenterology Global Health Hepatology Humans Liver diseases Medicine Medicine & Public Health Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - epidemiology Perspective Prevalence
Title	Past, present and future perspectives in nonalcoholic fatty liver disease
URI	https://link.springer.com/article/10.1038/s41575-019-0144-8 https://www.ncbi.nlm.nih.gov/pubmed/31024089 https://www.proquest.com/docview/2231963358 https://search.proquest.com/docview/2216285168
Volume	16
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZokRCXqrwXCjISJ4KXTfyIc6xgoYBYIXUrcYscxxG9pNU-_n9nbOexrCrRA5do5YzijefLzNjzIuRdU1RVpnXFeO0kE6BRmFF1zYTkGVe2qHPfReHsPF_81p_nYj54TIex_8ppGANeY-bsHbjdPxQG4DfwHK7Adbj-E99_mZDFcR3yirxzIBQOwRLFXWKlj4Jt0Qr3HXIvbdKYDTaRwDCNHa9NNFwXvgBozHRZT5OvMM3qCgt6rkIVJ4TQH9Btm51z-nOQNSbEAay2bfJ9Oj5lwMQmNT5liJP8fTSWXPwYyc5cFkzOQnXIqRuPhXrAvcBVI2CNpSePHV2CIuahRvaejA8V3ddgeeQYd4jhXkIwPSi0PszQO9i5LgNtCbQl0pb6gNzPQDD5fL_FstPcSkrfea5_kc4LzvXHvel27Zi9zcmeY93bK8tjchQ3GvQ0IOQRuefax-TBzxhK8YR8Q6B8oBEmFGBCA0zoGCb0sqVjmFAPE-phQiNMnpKLL_PlpzMW-2owy_Nsw4oGje7GVU2KjctgJcAMFKISRltVW9OAUFbcNYWbgfku7ayy8PI5r2e5AwHv-DNyCFO7F4S61Misds5qWYtCa2NtqlxRVDq3PDXNhLzvVqm8DuVTylu5MiEn3TqW8Ytal2C-opLgEm6_7W-DDETHlmnd1RZpUswEThXQPA_r388G2xes4ldMSNIxZHj4rX_l5Z2oX5GHwzdzQg43q617TQ7W9faNB9gNKl-P7Q
link.rule.ids	315,782,786,27933,27934,48346,48347,48361,49651,49652,49666
linkProvider	Nature Publishing
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LSwMxEB60BfXi-1GfETypwe5ms5scRVtabIuggp5CNslCQdbibg_-e5N9tIh60HNCkp3JZD72mwfAWcLj2GcsxkQbigPrUbAMtcYBJT4JFddR0UWh9xCNntltx5XJIXUuTBHtXlOSxUtdJoazq8y6msgFmrn4niDAbBGarti534Dm9fPLy239AIeUFg3ErGPkmFrIUpOZPy3y1R19w5jf-NHC7XTX_nXgdVitUCa6Lq_FBiyYdBOWhhWPvgX9e5nll2hS5h4hmWpUFhdBk3nyZYbGKUodUi-66I4VSmSef6BXF8qBKmZnG566ncebHq6aKmBFIj_HPHGIKzFx4rmuVX7ELQYIgjiQTIVaycRaZEhMwk3bYjeq2rGynxER3Y6MtW5DdqBhtzZ7gIwnqa-NUYzqgDMmlfJCw3nMIkU8mbTgvJatmJS1M0TBeRMmSuEIKxzhhCNYCw5r6YvKjDJhsYt7IQi1w6ezYWsAjtWQqXmbujmeSwP1Qjtnt9TabDeLXV0JN96Ci1pF88V_Pcr-n2afwHLvcTgQg_7o7gBW_ELf7i_NITTy96k5gsVMT4-rS_oJAj3eyQ
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwEB7xkFZceLRAFyg1Uk9Qi00cJ_YJtcAKtHS7EiD1Zjl-SEhVWJHsgX_POI9FaOmh6jmW7cx4PJ_8zQPgq5d5HguRU2Ydpwl6FKpTa2nCWcxSI21Wd1G4us3Gv8XFZSiTc9blwtTR7h0l2eQ0hCpNRXU6tb5NEhenJbqdLASdhVifJKFiGVbDqxge8dUfo9H4V3cZp5zXzcTQSUrKEb50xOZ7k7x1TQt4c4ErrV3QcOO_N78J6y36JN-b47IFS674AL2fLb_-Ea4nuqy-kWmTk0R0YUlTdIRMX5MyS_JQkCIg-Lq77oMhXlfVM_kTQjxIy_hsw_3w8u78irbNFqhhWVxR6QMS8y73UehmFWcSsUGS5IkWJrVGe7TUlDkv3QAxHTeD3OBvZMwOModW79gOrODS7hMQF2keW-eM4DaRQmhjotRJmYvMsEj7Phx3clbTpqaGqrlwJlQjHIXCUUE4SvThoNOEas2rVIhpws3BOH4-mn9Gwwhshy7c4yyMiUJ6aJTimN1Gg_PVENOG0m6yDyedul4n_-tW9v5p9BfoTS6G6uZ6PNqHtbhWd3i8OYCV6mnmPsNyaWeH7Xl9AQZa53Y
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Past%2C+present+and+future+perspectives+in+nonalcoholic+fatty+liver+disease&rft.jtitle=Nature+reviews.+Gastroenterology+%26+hepatology&rft.au=Sanyal%2C+Arun+J.&rft.date=2019-06-01&rft.pub=Nature+Publishing+Group+UK&rft.issn=1759-5045&rft.eissn=1759-5053&rft.volume=16&rft.issue=6&rft.spage=377&rft.epage=386&rft_id=info:doi/10.1038%2Fs41575-019-0144-8&rft.externalDocID=10_1038_s41575_019_0144_8
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1759-5045&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1759-5045&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1759-5045&client=summon