The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility

FcγRIIB-deficient mice generated in 129 background (FcγRIIB(129)(-/-)) if back-crossed into C57BL/6 background exhibit a hyperactive phenotype and develop lethal lupus. Both in mice and humans, the Fcγr2b gene is located within a genomic interval on chromosome 1 associated with lupus susceptibility....

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 187; no. 3; pp. 1304 - 1313
Main Authors:	Boross, Peter, Arandhara, Victoria L, Martin-Ramirez, Javier, Santiago-Raber, Marie-Laure, Carlucci, Francesco, Flierman, Roelof, van der Kaa, Jos, Breukel, Cor, Claassens, Jill W C, Camps, Marcel, Lubberts, Erik, Salvatori, Daniela, Rastaldi, Maria Pia, Ossendorp, Ferry, Daha, Mohamed R, Cook, H Terence, Izui, Shozo, Botto, Marina, Verbeek, J Sjef
Format:	Journal Article
Language:	English
Published:	United States 01-08-2011
Subjects:	Animals Cells, Cultured Crosses, Genetic Disease Models, Animal Embryonic Stem Cells - immunology Embryonic Stem Cells - metabolism Female Gene Targeting Genetic Predisposition to Disease - prevention & control Humans Immunoglobulin G - metabolism Immunophenotyping Lupus Nephritis - genetics Lupus Nephritis - immunology Lupus Nephritis - prevention & control Male Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Receptors, IgG - deficiency Receptors, IgG - genetics Receptors, IgG - physiology
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