STAG2 expression in oral cancer and potentially malignant lesions

• Published in: Tumor biology Vol. 35; no. 4; pp. 3641 - 3645
• Main Authors: Bernardes, Vanessa Fátima, Correa, Gefter Thiago Batista, Loyola, Adriano Mota, Cardoso, Sérgio Vitorino, de Paula, Alfredo Maurício Batista, Cabral, Mônica Maria Demas Álvares, Gomez, Ricardo Santiago, Gomes, Carolina Cavaliéri
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-04-2014; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, Nuclear - analysis; Biomedical and Life Sciences; Biomedicine; Brain cancer; Cancer Research; Cheilitis - genetics; Cheilitis - metabolism; Female; Gastric cancer; Glioblastoma - chemistry; Glioblastoma - genetics; Humans; Immunohistochemistry; Leukoplakia, Oral - chemistry; Leukoplakia, Oral - genetics; Lip Neoplasms - chemistry; Lip Neoplasms - genetics; Male; Middle Aged; Mouth Neoplasms - chemistry; Mouth Neoplasms - genetics; Oral cancer; Protein expression; Research Article; Stomach Neoplasms - chemistry; Stomach Neoplasms - genetics; STAG2; Oral cancer; Actinic cheilitis; Oral leukoplakia; Glioblastoma; Lip cancer; Gastric adenocarcinoma
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1007/s13277-013-1482-8

Oral cancer is a world health problem, and one of the highest incidence rates of oral cancer worldwide occurs in Brazil. STAG2 is part of the cohesin complex which is responsible for sister chromatid cohesion. STAG2 loss of expression was reported in a range of tumors, and STAG2 loss was found to cause chromosomal instability and aneuploidy in cancer cells. On the basis of these findings, we investigated STAG2 expression in oral cancer and potentially malignant lesions. We investigated STAG2 immunoexpression in oral cancer, lip cancer, oral leukoplakia, and actinic cheilitis, including complete clinical information. Normal oral mucosa samples were included as normal controls. STAG2 protein was highly expressed in all samples. We further tested STAG2 expression in gastric adenocarcinomas and glioblastomas, as these tumor types were previously shown to lose STAG2 expression. We found homogenous expression of STAG2 by these tumor cells. Our results suggest that STAG2 loss of expression is not a common event in oral carcinogenesis.