Association between coronary artery disease severity and overactive bladder in geriatric patients

• Published in: World journal of urology Vol. 36; no. 1; pp. 35 - 40
• Main Authors: Kilinc, Muhammet Fatih, Yasar, Erdogan, Aydin, Halil Ibrahim, Yildiz, Yildiray, Doluoglu, Omer Gokhan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 2018; Springer Nature B.V
• Subjects: Aged, 80 and over; Angiography; Body mass index; Cardiovascular disease; Cholesterol; Coronary artery; Coronary Artery Disease - complications; Coronary Artery Disease - epidemiology; Coronary vessels; Cross-Sectional Studies; Female; Glucose; Heart diseases; Humans; Low density lipoprotein; Male; Medical imaging; Medicine; Medicine & Public Health; Multiple regression analysis; Nephrology; Oncology; Original Article; Patients; Severity of Illness Index; Smoking; Urea; Urinalysis; Urinary bladder; Urinary Bladder, Overactive - complications; Urine; Urology; Overactive bladder; Coronary artery disease; Geriatrics
• ISSN: 0724-4983; 1433-8726
• DOI: 10.1007/s00345-017-2098-1

Purpose
To investigate the association between overactive bladder (OAB) and coronary artery disease (CAD) as demonstrated on coronary angiography in patients > 65 years.
Methods
The patients who were > 65 years completed an OAB-V8 form before undergoing coronary angiography at a tertiary care hospital. The presence of OAB was documented using the self-administered OAB-V8 questionnaire. Formal stratification of the coronary vessels plaque burden was assessed by calculation of a Gensini score for each patient. Body mass index (BMI) blood urea nitrogen (BUN), serum lipid profile, fasting plasma glucose, urinalysis, urine culture, uroflowmetry, and postvoiding residual urine volume were measured for each patient.
Results
A total of 308 patients were analysed. Before coronary angiography, the patients were divided into two groups according to the score on the OAB-V8 questionnaire. The OAB group (
n
: 153) comprised those with a score ≥ 8 and the non-OAB group (
n
: 155), those with a score < 8. The mean age of the patients was 75.08 ± 5.01 years in the OAB group and 68.73 ± 3.26 years in the non-OAB group (
p
 < 0.001). The Gensini scores of the patients in the OAB and non-OAB groups were 22.48 ± 3.51 and 5.89 ± 2.72, respectively (
p
 = 0.001). In multiple regression analysis, no significant difference was determined between the groups in terms of gender, fasting blood glucose level, presence of hypertension, smoking, BMI, and BUN, except LDL and cholesterol levels.
Conclusions
In this preliminary investigation, the incidence of severe CAD was found to be higher in patients with OAB symptoms.