In vitro toxicity of MTA compared with other primary teeth pulpotomy agents

• Published in: The Journal of clinical pediatric dentistry Vol. 33; no. 3; p. 217
• Main Authors: de Menezes, José Vitor Nogara Borges, Takamori, Esther Rieko, Bijella, Maria Francisca Thereza Borro, Granjeiro, José Mauro
• Format: Journal Article
• Language: English
• Published: United States 01-04-2009
• Subjects: 3T3 Cells; Aluminum Compounds - toxicity; Animals; Calcium Compounds - toxicity; Calcium Hydroxide - toxicity; Cell Membrane - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Coloring Agents; Drug Combinations; Ferric Compounds - toxicity; Formocresols - toxicity; Lethal Dose 50; Mice; Mitochondria - drug effects; Neutral Red; Oxides - toxicity; Pulpotomy - adverse effects; Root Canal Filling Materials - toxicity; Silicates - toxicity; Tetrazolium Salts; Thiazoles
• ISSN: 1053-4628
• DOI: 10.17796/jcpd.33.3.cq7677j4l532r1rg

The main goal of this work is to compare the In vitro toxicity of MTA with other primary teeth pulpotomy agents.
The In vitro toxicity of MTA, calcium hydroxide, ferric sulphate solution, diluted formocresol and Buckley's formocresol were tested using MTT and Neutral Red Uptake cell viability assays. The results for MTA were compared to those obtained for the other substances using ANOVA and Tukey statistical tests (p < 0.05).
MTA had the lower in vitro toxicity and Buckley's formocresol, the higher, with statically significant difference.
Among the primary teeth pulpotomy agents tested, MTA showed the lower In vitro toxicity, standing as the most promising substitute to formocresol.