Development of Novel PSMA Ligands for Imaging and Therapy with Copper Isotopes

Prostate-specific membrane antigen (PSMA)-binding tracers have been shown to be promising agents for the specific targeting of prostate tumors. On labeling with the short-lived isotopes F and Ga, excellent molecular imaging performance is achieved. This potential could be further exploited using lon...

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Bibliographic Details
Published in:	Journal of Nuclear Medicine Vol. 61; no. 1; pp. 70 - 79
Main Authors:	Carlos Dos Santos, José, Beijer, Barbro, Bauder-Wüst, Ulrike, Schäfer, Martin, Leotta, Karin, Eder, Matthias, Benešová, Martina, Kleist, Christian, Giesel, Frederik, Kratochwil, Clemens, Kopka, Klaus, Haberkorn, Uwe, Mier, Walter
Format:	Journal Article
Language:	English
Published:	United States Society of Nuclear Medicine 01-01-2020
Subjects:	Antigens Binding Chelating agents Chromatography Copper Copper compounds Copper isotopes Dosimeters Dosimetry High performance liquid chromatography Imaging In vivo methods and tests Injection Internalization Isotopes Kidneys Lesions Ligands Liquid chromatography Lymph nodes Mass spectrometry Mass spectroscopy Molecular weight Positron emission Positron emission tomography Prostate cancer Radiation therapy Radiolabelling Solid phase methods Solid phase synthesis Solid phases Stability Tomography Tracers Tumors Urea PSMA prostate cancer copper radioisotopes PET imaging radiotracer endoradiotherapy
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