PLAG1 expression is maintained in recurrent pleomorphic adenoma

• Published in: Virchows Archiv : an international journal of pathology Vol. 469; no. 4; pp. 477 - 481
• Main Authors: de Brito, Beatriz Samara, Gaspar, Natália Giovanelli, Egal, Erika Said Abu, Sanchez-Romero, Celeste, Martins, Antonio Santos, Tincani, Álfio José, de Oliveira Gondak, Rogério, de Almeida, Oslei Paes, Kowalski, Luiz Paulo, Altemani, Albina, Mariano, Fernanda Viviane
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-10-2016; Springer Nature B.V
• Subjects: Adenoma, Pleomorphic - diagnosis; Adenoma, Pleomorphic - metabolism; Adenoma, Pleomorphic - pathology; Adult; Aged; Case Report; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Female; Humans; Immunohistochemistry - methods; In Situ Hybridization, Fluorescence - methods; Male; Medicine; Medicine & Public Health; Middle Aged; Pathology; Recurrence; Salivary Gland Neoplasms - diagnosis; Salivary Gland Neoplasms - metabolism; Salivary Gland Neoplasms - pathology; Transcription Factors - genetics; Immunohistochemistry; Recurrent pleomorphic adenoma; PLAG1; Pleomorphic adenoma
• ISSN: 0945-6317; 1432-2307
• DOI: 10.1007/s00428-016-1980-3

The proto-oncogene (
pleomorphic adenoma gene 1
(
PLAG1
)) is immunohistochemically overexpressed in pleomorphic adenoma (PA). Its expression in recurrent pleomorphic adenoma (RPA), however, has not been investigated. Since complex mechanisms are involved in tumor recurrence, the aim of this study was to investigate whether PLAG1 overexpression occurs in RPA. We studied PLAG1 protein expression in 40 PAs and 36 RPAs by immunohistochemistry. Cases with immunopositive cells were classified into two categories, between 10 and 50 % and >50 %. In both groups, PLAG1 expression was observed in both epithelial and myoepithelial cells. Of PAs, 37 cases (93 %) were positive, while this was the case in 34 RPA cases (94 %). Our findings suggest that in addition to morphological similarity, PA and RPA express PLAG1, which might play a role in tumor recurrence. Furthermore, as for PA, expression of PLAG1 can be considered a valuable diagnostic marker for RPA.