Experimental protocol for evaluation of biomaterials in an in-vivo silicone implant coverage
To describe an experimental surgical model in rats using a dual-plane technique for evaluation of biomaterials in an in-vivo silicone implant coverage. This study was developed following the ISO 10993-6 standard. In this study, 40 male Wistar rats weighing between 250 and 350 g were used, distribute...
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| Published in: | Acta Cirúrgica Brasileira Vol. 39; p. e396724 |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
01-01-2024
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| Abstract | To describe an experimental surgical model in rats using a dual-plane technique for evaluation of biomaterials in an in-vivo silicone implant coverage.
This study was developed following the ISO 10993-6 standard. In this study, 40 male Wistar rats weighing between 250 and 350 g were used, distributed into two groups: experimental, biomaterial superimposed on the minimammary prosthesis (MP); and control, MP without implantation of the biomaterial, with eight animals at each biological point: 1, 2, 4, 12, and 26 weeks. Thus, at the end of biological points (1, 2, 4, 12, and 26 weeks; n = 8 animals per week), the tissue specimens achieved were fixed in buffered formalin and stained with hematoxylin-eosin.
Macroscopically, throughout the study, no postoperative complications were apparent. In the histological analysis, it was possible to observe the evolution of the inflammatory response, tissue repair, and fibrous capsule during the biological points.
The experimental model described in this study proved to be suitable for evaluating the biomaterial used in the coverage of breast silicone implants. |
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| AbstractList | To describe an experimental surgical model in rats using a dual-plane technique for evaluation of biomaterials in an in-vivo silicone implant coverage.
This study was developed following the ISO 10993-6 standard. In this study, 40 male Wistar rats weighing between 250 and 350 g were used, distributed into two groups: experimental, biomaterial superimposed on the minimammary prosthesis (MP); and control, MP without implantation of the biomaterial, with eight animals at each biological point: 1, 2, 4, 12, and 26 weeks. Thus, at the end of biological points (1, 2, 4, 12, and 26 weeks; n = 8 animals per week), the tissue specimens achieved were fixed in buffered formalin and stained with hematoxylin-eosin.
Macroscopically, throughout the study, no postoperative complications were apparent. In the histological analysis, it was possible to observe the evolution of the inflammatory response, tissue repair, and fibrous capsule during the biological points.
The experimental model described in this study proved to be suitable for evaluating the biomaterial used in the coverage of breast silicone implants. ABSTRACT Purpose: To describe an experimental surgical model in rats using a dual-plane technique for evaluation of biomaterials in an in-vivo silicone implant coverage. Methods: This study was developed following the ISO 10993-6 standard. In this study, 40 male Wistar rats weighing between 250 and 350 g were used, distributed into two groups: experimental, biomaterial superimposed on the minimammary prosthesis (MP); and control, MP without implantation of the biomaterial, with eight animals at each biological point: 1, 2, 4, 12, and 26 weeks. Thus, at the end of biological points (1, 2, 4, 12, and 26 weeks; n = 8 animals per week), the tissue specimens achieved were fixed in buffered formalin and stained with hematoxylin-eosin. Results: Macroscopically, throughout the study, no postoperative complications were apparent. In the histological analysis, it was possible to observe the evolution of the inflammatory response, tissue repair, and fibrous capsule during the biological points. Conclusions: The experimental model described in this study proved to be suitable for evaluating the biomaterial used in the coverage of breast silicone implants. |
| Author | Moreno, Amanda Dourado Barbosa Júnior, Aryon de Almeida Barreto, Isabela Cerqueira Meneses, José Valber Lima Silva, Chenia Frutuoso Felzemburgh, Victor de Araújo Miguel, Fúlvio Borges |
| AuthorAffiliation | 1 Universidade Federal da Bahia – Institute of Health Sciences – Laboratory of Tissue Bioengineering and Biomaterials – Salvador (BA) – Brazil 3 Universidade Federal da Bahia – Faculty of Medicine of Bahia – Salvador (BA) – Brazil 4 Instituto de Patologia Geral e Cutânea – Salvador (BA) – Brazil 2 Universidade Federal da Bahia – Post-graduation Program in Interactive Processes of the Organs and Systems – Salvador (BA) – Brazil |
| AuthorAffiliation_xml | – name: 2 Universidade Federal da Bahia – Post-graduation Program in Interactive Processes of the Organs and Systems – Salvador (BA) – Brazil – name: 1 Universidade Federal da Bahia – Institute of Health Sciences – Laboratory of Tissue Bioengineering and Biomaterials – Salvador (BA) – Brazil – name: 4 Instituto de Patologia Geral e Cutânea – Salvador (BA) – Brazil – name: 3 Universidade Federal da Bahia – Faculty of Medicine of Bahia – Salvador (BA) – Brazil |
| Author_xml | – sequence: 1 givenname: Chenia Frutuoso orcidid: 0000-0001-8588-4586 surname: Silva fullname: Silva, Chenia Frutuoso organization: Universidade Federal da Bahia - Post-graduation Program in Interactive Processes of the Organs and Systems - Salvador (BA) - Brazil – sequence: 2 givenname: Victor de Araújo orcidid: 0000-0002-0880-2687 surname: Felzemburgh fullname: Felzemburgh, Victor de Araújo organization: Universidade Federal da Bahia - Institute of Health Sciences - Laboratory of Tissue Bioengineering and Biomaterials - Salvador (BA) - Brazil – sequence: 3 givenname: Amanda Dourado orcidid: 0009-0001-8364-886X surname: Moreno fullname: Moreno, Amanda Dourado organization: Universidade Federal da Bahia - Institute of Health Sciences - Laboratory of Tissue Bioengineering and Biomaterials - Salvador (BA) - Brazil – sequence: 4 givenname: José Valber Lima orcidid: 0000-0001-5538-7108 surname: Meneses fullname: Meneses, José Valber Lima organization: Universidade Federal da Bahia - Faculty of Medicine of Bahia - Salvador (BA) - Brazil – sequence: 5 givenname: Aryon de Almeida orcidid: 0000-0001-6210-2107 surname: Barbosa Júnior fullname: Barbosa Júnior, Aryon de Almeida organization: Instituto de Patologia Geral e Cutânea - Salvador (BA) - Brazil – sequence: 6 givenname: Isabela Cerqueira orcidid: 0000-0003-2663-7395 surname: Barreto fullname: Barreto, Isabela Cerqueira organization: Universidade Federal da Bahia - Post-graduation Program in Interactive Processes of the Organs and Systems - Salvador (BA) - Brazil – sequence: 7 givenname: Fúlvio Borges orcidid: 0000-0002-0607-0208 surname: Miguel fullname: Miguel, Fúlvio Borges organization: Universidade Federal da Bahia - Post-graduation Program in Interactive Processes of the Organs and Systems - Salvador (BA) - Brazil |
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| Notes | Section editor: Eiji Kobayashi https://orcid.org/0000-0001-7038-7931 Conflict of interest: Nothing to declare. |
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This... ABSTRACT Purpose: To describe an experimental surgical model in rats using a dual-plane technique for evaluation of biomaterials in an in-vivo silicone implant... |
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| Title | Experimental protocol for evaluation of biomaterials in an in-vivo silicone implant coverage |
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