Prognostic utility of neutrophil-to-lymphocyte and platelets-to-lymphocyte ratio in predicting biochemical recurrence post robotic prostatectomy

• Published in: Biomarkers in medicine Vol. 12; no. 8; pp. 841 - 848
• Main Authors: Zanaty, Marc, Ajib, Khaled, Alnazari, Mansour, El Rassy, Elie, Aoun, Fouad, Zorn, Kevin C, El-Hakim, Assaad
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01-08-2018
• Subjects: Age; Antigens; biochemical recurrence; biomarkers; Blood platelets; Cancer surgery; Cancer therapies; CAPRA-S; carcinogenesis; Chemotherapy; Inflammation; Kidney cancer; Lymph nodes; Lymphocytes; Medical prognosis; Metastasis; Multivariate analysis; Neutrophils; NLR; Platelets; PLR; Prostate cancer; Prostatectomy; PSA; robot-assisted radical prostatectomy; Robotic surgery; Studies; Urological surgery; prostate cancer; carcinogenesis; robot-assisted radical prostatectomy; NLR; biochemical recurrence; inflammation; biomarkers; PLR; CAPRA-S; PSA
• ISSN: 1752-0363; 1752-0371
• DOI: 10.2217/bmm-2017-0321

Utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting biochemical recurrence (BCR) in patients with localized prostate cancer.
Retrospective analysis of patients operated by robot-assisted radical prostatectomy. Variables included were: NLR, PLR pre-operative prostate specific antigen, pathological Gleason score, surgical margins status, extracapsular extension, seminal vesical invasion, and lymph node status.
Out of 321 patients, no association between NLR or PLR and BCR was detected. Predictors of BCR were pathological Gleason score, extracapsular extension and positive surgical margins. On multivariate analysis, the Gleason Score, extracapsular extension and positive surgical margins remained the only predictors of BCR.
Neither elevated NLR nor PLR predicted an increased risk of BCR.