Combat Wound Initiative program

• Published in: Military medicine Vol. 175; no. 7 Suppl; pp. 18 - 24
• Main Authors: Stojadinovic, Alexander, Elster, Eric, Potter, Benjamin K, Davis, Thomas A, Tadaki, Doug K, Brown, Trevor S, Ahlers, Stephen, Attinger, Christopher E, Andersen, Romney C, Burris, David, Centeno, Jose, Champion, Hunter, Crumbley, David R, Denobile, John, Duga, Michael, Dunne, James R, Eberhardt, John, Ennis, William J, Forsberg, Jonathan A, Hawksworth, Jason, Helling, Thomas S, Lazarus, Gerald S, Milner, Stephen M, Mullick, Florabel G, Owner, Christopher R, Pasquina, Paul F, Patel, Chirag R, Peoples, George E, Nissan, Aviram, Ring, Michael, Sandberg, Glenn D, Schaden, Wolfgang, Schultz, Gregory S, Scofield, Tom, Shawen, Scott B, Sheppard, Forest R, Stannard, James P, Weina, Peter J, Zenilman, Jonathan M
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01-07-2010
• Subjects: Biomarkers; Burns - therapy; Clinical Trials as Topic; High-Energy Shock Waves - therapeutic use; Humans; Military Personnel; Neovascularization, Physiologic; Public-Private Sector Partnerships; Translational Medical Research; United States; Warfare; Wound Healing; Wounds and Injuries - therapy; United States
• ISSN: 0026-4075; 1930-613X
• DOI: 10.7205/MILMED-D-10-00156

The Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy (ESWT) study in complex wounds after establishing the potential efficacy, biologic mechanisms, and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healing/failure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care.