A New Group of Antibiotics, Hydroxamic Acid Antimycotic Antibiotics. IV. Structures of Enactins Ia, Ib1, Ib2 and Va

A New Group of Antibiotics, Hydroxamic Acid Antimycotic Antibiotics. IV. Structures of Enactins Ia, Ib1, Ib2 and Va

Structures of enactins Ia, Ib1, Ib2 and Va were determined by spectroscopic studies using their bis-2, 4-dinitrophenyl derivatives. Both enactins and neoenactins contain L-serine to form the hydroxamic acid structure. Their physico-chemical and biological properties are closely related. The structur...

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Bibliographic Details
Published in:Chemical & pharmaceutical bulletin Vol. 39; no. 6; pp. 1436 - 1439
Main Authors: YAMAMOTO, Katsumi, SHIINOKI, Yoshikazu, FURUKAWA, Jun, NAKAMURA, Shoshiro
Format: Journal Article
Language:English
Published: Tokyo The Pharmaceutical Society of Japan 1991
Japan Science and Technology Agency
Subjects:
antimycotic antibiotics
enactin
hydroxamic acid
neoenactin
potentiator
Streptomyces roseoviridis
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Summary:Structures of enactins Ia, Ib1, Ib2 and Va were determined by spectroscopic studies using their bis-2, 4-dinitrophenyl derivatives. Both enactins and neoenactins contain L-serine to form the hydroxamic acid structure. Their physico-chemical and biological properties are closely related. The structures of neoenactin congeners have been previosuly reported and enactins Ia and Va are proved to be 19-hydroxyneoenactin B2 and 14-dihydroneoenactin M1, respectively. Both enactins Ib1 and Ib2 are determined to be 19-hydroxyneoenactin B1 and considered to be diastereoisomers at the 19-position, though their steric structures at this positioin remain to be determined.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.39.1436