TTV and other anelloviruses: The astonishingly wide spread of a viral infection

• Published in: Aspects of molecular medicine Vol. 1; p. None
• Main Authors: Spezia, Pietro Giorgio, Focosi, Daniele, Baj, Andreina, Novazzi, Federica, Ferrante, Francesca Drago, Carletti, Fabrizio, Minosse, Claudia, Matusali, Giulia, Maggi, Fabrizio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 2023; Elsevier
• Subjects: Anellovirus; Immune system; TTMDV; TTMV; TTV; Virome; TTMDV; Virome; TTMV; TTV; Anellovirus; Immune system
• ISSN: 2949-6888; 2949-6888
• DOI: 10.1016/j.amolm.2023.100006

The broad family of viruses known as anelloviruses (AV) infects both humans and numerous animal species. They have a tiny, covalently closed single-stranded DNA genome and the astonishing capacity to infect a very high percentage of healthy and ill people with chronic infections that could last a lifetime. AV, and particularly the prototype Torquetenovirus, have established a successful interaction with the host's immune system and the rate at which they replicate is a gauge to measure overall immune function, even though many aspects of their life cycle and pathogenesis are still poorly understood.