Protection against Diabetes by MHC Heterozygosity and Reversal by Cyclophosphamide

In type I diabetes in both rodents and humans, genetic susceptibility to disease is strongly linked to MHC class II alleles. In some cases, however, certain class II alleles provide resistance to disease. To examine this effect in a well-defined system, we studied double transgenic mice expressing i...

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Bibliographic Details
Published in:	Cellular immunology Vol. 184; no. 2; pp. 112 - 120
Main Authors:	Wu, Adrian Y., Schulman, Stacey J., Marconi, Lori Anne, Reilly, Christina R., Scott, Bernadette, Lo, David
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 15-03-1998
Subjects:	Animals Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - prevention & control autoimmunity Base Sequence CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cyclophosphamide - pharmacology Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - prevention & control DNA Primers - genetics Genes, MHC Class II genetics Hemagglutinin Glycoproteins, Influenza Virus - genetics Heterozygote Humans Interferon-gamma - genetics interferon-γ interleukin-4 Interleukin-4 - genetics major histocompatibility complex (MHC) Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, Transgenic Polymerase Chain Reaction Receptors, Antigen, T-Cell - genetics interleukin-4 interferon-γ genetics autoimmunity major histocompatibility complex (MHC)
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