Evaluation of Oral Glucose Tolerance Test in Children With Epilepsy

• Published in: Journal of child neurology Vol. 28; no. 11; pp. 1437 - 1442
• Main Authors: Varlamis, Sotirios, Vavatsi, Norma, Pavlou, Evangelos, Kotsis, Vasileios, Spilioti, Martha, Kavga, Maria, Varlamis, George, Sotiriadou, Foteini, Agakidou, Eleni, Voutoufianakis, Spyridon, Evangeliou, Athanasios E.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-11-2013
• Subjects: drug-resistant epilepsy; insulin; glucose tolerance; glucose metabolism; HbA1c
• ISSN: 0883-0738; 1708-8283
• DOI: 10.1177/0883073812460919

Glucose metabolism of children with drug-resistant epilepsy, controlled by antiepileptic drugs epilepsy, and first-time nonfebrile seizures was studied through the performance of an oral glucose tolerance test and through insulin, C-peptide, and glycosylated hemoglobin measurements. In the refractory epilepsy group, there were more abnormal oral glucose tolerance test results (62.07%) in comparison to the controlled epilepsy group (25%) and the group of first-time seizures (21.21%). There was a significant difference between the group of refractory epilepsy and every other group concerning the abnormality of the oral glucose tolerance test (P < .05). The mean values of insulin, HbA1c, and C-peptide levels were normal for all groups. The results of the present study suggest that there is a distinction of refractory epilepsies from the drug-controlled ones and the first-induced seizures relating to their metabolic profile, regardless of the type of seizures.