Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus

Protein posttranslational modifications (PTMs) arise in a number of normal cellular biological pathways and in response to pathology caused by inflammation and/or infection. Indeed, a number of PTMs have been identified and linked to specific autoimmune responses and metabolic pathways. One particul...

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Bibliographic Details
Published in:	Autoimmunity (Chur, Switzerland) Vol. 56; no. 1; p. 2282945
Main Authors:	Yang, Mei-Ling, Lam, TuKiet T, Kanyo, Jean, Kang, Insoo, Zhou, Zhaohui Sunny, Clarke, Steven G, Mamula, Mark J
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis Group 01-12-2023
Subjects:	Autoimmunity Humans isoaspartyl modification Oxidative Stress posttranslational modifications Protein D-Aspartate-L-Isoaspartate Methyltransferase - genetics Protein D-Aspartate-L-Isoaspartate Methyltransferase - metabolism protein L-isoaspartate O-methyltransferase Protein Processing, Post-Translational systemic lupus erythematosus T-Lymphocytes - metabolism TCR signaling ZAP-70 Protein-Tyrosine Kinase - genetics ZAP-70 Protein-Tyrosine Kinase - metabolism TCR signaling isoaspartyl modification systemic lupus erythematosus posttranslational modifications protein L-isoaspartate O-methyltransferase
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