Novel, selective mechanism-based inhibitors of the herpes proteases

• Published in: Bioorganic & medicinal chemistry letters Vol. 6; no. 20; pp. 2467 - 2472
• Main Authors: Pinto, Ivan L., West, Andrew, Debouck, Christine M., DiLella, Anthony G., Gorniak, Joselina G., O'Donnell, Kevin C., O'Shannessy, Daniel J., Patel, Arunbai, Jarvest, Richard L.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 22-10-1996
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/0960-894X(96)00456-8

A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyl oxazolones and the benzylidine N-sulphonyloxyimidazolones, have been shown to be submicromolar inhibitors of HSV-2 and HCMV proteases which are selective relative to a panel of standard serine proteases.
Two new families of serine protease inhibitor, the spirocyclopropyl oxazolones and the benzylidine N-sulphonyloxyimidazolones, have been shown to be submicromolar inhibitors of HSV-2 and HCMV proteases.