Pronounced asymmetric amplification in the aldol condensation of Chan's diene promoted by a Ti(IV)/BINOL complex

Graphic A strong enhancement of the enantiomeric excess can be obtained by performing the enantioselective aldol reaction of Chan's diene in the presence of enantiomerically enriched Ti(O- i-Pr) 4/BINOL catalysts derived from mixing pre-prepared solutions of enantiopure Ti(O- i-Pr) 4/( R)-BINOL...

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Bibliographic Details
Published in:	Tetrahedron: asymmetry Vol. 15; no. 15; pp. 2421 - 2424
Main Authors:	Villano, Rosaria, Acocella, Maria Rosaria, De Rosa, Margherita, Soriente, Annunziata, Scettri, Arrigo
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 09-08-2004
Online Access:	Get full text
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Summary:	Graphic A strong enhancement of the enantiomeric excess can be obtained by performing the enantioselective aldol reaction of Chan's diene in the presence of enantiomerically enriched Ti(O- i-Pr) 4/BINOL catalysts derived from mixing pre-prepared solutions of enantiopure Ti(O- i-Pr) 4/( R)-BINOL and Ti(O- i-Pr) 4/( S)-BINOL at different concentrations.
ISSN:	0957-4166 1362-511X
DOI:	10.1016/j.tetasy.2004.06.009