Antigen Availability and DOCK2-Driven Motility Govern CD4 + T Cell Interactions with Dendritic Cells In Vivo

Parenchymal migration of naive CD4 T cells in lymph nodes (LNs) is mediated by the Rac activator DOCK2 and PI3Kγ and is widely assumed to facilitate efficient screening of dendritic cells (DCs) presenting peptide-MHCs (pMHCs). Yet how CD4 T cell motility, DC density, and pMHC levels interdependently...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 199; no. 2; pp. 520 - 530
Main Authors:	Ackerknecht, Markus, Gollmer, Kathrin, Germann, Philipp, Ficht, Xenia, Abe, Jun, Fukui, Yoshinori, Swoger, Jim, Ripoll, Jorge, Sharpe, James, Stein, Jens V
Format:	Journal Article
Language:	English
Published:	United States American Association of Immunologists 15-07-2017
Subjects:	Animals Antigen Presentation CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell Communication Cell interactions Cell Movement Cell proliferation Class Ib Phosphatidylinositol 3-Kinase - deficiency Class Ib Phosphatidylinositol 3-Kinase - genetics Class Ib Phosphatidylinositol 3-Kinase - metabolism Dendritic cells Dendritic Cells - immunology GTPase-Activating Proteins - deficiency GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Histocompatibility Antigens - immunology Intravital Microscopy - methods Lymph nodes Lymph Nodes - immunology Lymph Nodes - ultrastructure Lymphocyte Activation Lymphocytes Lymphocytes T Mice Motility
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