Serpin Family B Member 2 Polymorphisms in Patients with Diabetic Kidney Disease: An Association Study

• Published in: International journal of molecular sciences Vol. 25; no. 20; p. 10906
• Main Authors: Tziastoudi, Maria, Pissas, Georgios, Golfinopoulos, Spyridon, Filippidis, Georgios, Poulianiti, Christina, Tsironi, Evangelia E, Dardiotis, Efthimios, Eleftheriadis, Theodoros, Stefanidis, Ioannis
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10-10-2024; MDPI
• Subjects: Aged; Care and treatment; Case-Control Studies; Communication; Cytokines; Development and progression; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetic Nephropathies - genetics; Diabetic nephropathy; Diabetic neuropathies; Diabetic neuropathy; Diabetic retinopathy; Diseases; Female; Genetic aspects; Genetic Association Studies; Genetic Predisposition to Disease; Genotype & phenotype; Greece; Hospitals; Humans; Kidney diseases; Male; Medical research; Medicine, Experimental; Middle Aged; Nephrology; Ophthalmology; Pathogenesis; Plasminogen Activator Inhibitor 2 - genetics; Polymorphism, Single Nucleotide; Type 2 diabetes; White people; Greece; United States > US; diabetic kidney disease; Serpin Family B Member 2 (SERPINB2); diabetes mellitus; polymorphism; association study
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms252010906

Diabetic kidney disease (DKD) is a serious microvascular complication of type 2 diabetes mellitus (T2DM). Despite the numerous genetic loci that have been associated with the disease in T2DM, the genetic architecture of DKD remains unclear until today. In contrast to
, the contribution of
has not been examined in DKD. Therefore, we conducted the first genetic association study of
to elucidate its role in DKD. In total, the study involved 197 patients with DKD, 155 patients with T2DM without microvascular complications (diabetic kidney disease, diabetic retinopathy, and diabetic neuropathy), and 246 healthy controls. The generalized odds ratio (OR
) was calculated to estimate the risk on DKD development. The present association study regarding
SNPs (rs4941230, rs3819335, rs13381217, rs6140) did not reveal any significant association between
variants and DKD. Additional studies in other populations are necessary to further investigate the role of this gene in the progression of diabetes mellitus and development of DKD.