Zanthoxylum avicennae extracts inhibit cell proliferation through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells in vitro and in vivo

Hepatocellular carcinoma is a common type of cancer that is usually associated with poor prognosis. In this study, we examined the in vitro and in vivo mechanisms of the traditional Vietnamese herb Zanthoxylum avicennae on the inhibition of HA22T human hepatocellular carcinoma cell proliferation. HA...

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Bibliographic Details
Published in:	International journal of molecular medicine Vol. 29; no. 6; pp. 1045 - 1052
Main Authors:	Dung, Tran, Chang, Hsien-Cheh, Binh, Truong, Lee, Maw-Rong, Tsai, Chang-Hai, Tsai, Fuu-Jen, Kuo, Wei-Wen, Chen, Li-Mien, Huang, Chih-Yang
Format:	Journal Article
Language:	English
Published:	Greece D.A. Spandidos 01-06-2012
Subjects:	Animals Blotting, Western Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - pathology Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Down-Regulation - drug effects Enzyme Activation - drug effects Humans Liver Neoplasms - drug therapy Liver Neoplasms - enzymology Liver Neoplasms - pathology Male Mice Mice, Nude Models, Biological Okadaic Acid - pharmacology Phosphorylation - drug effects Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Protein Phosphatase 2 - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - metabolism Xenograft Model Antitumor Assays Zanthoxylum - chemistry
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