Two-Component 10-23 DNA Enzymes

A new strategy for engineering of catalytic two-component constructions based on 10-23 DNAzyme was proposed. The using of a combination of shortened DNAzyme with 2′-O-methyl oligomers as effectors significantly increased the catalytic activity of this DNAzyme.

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Bibliographic Details
Published in:	Nucleosides, nucleotides & nucleic acids Vol. 23; no. 6-7; pp. 1031 - 1035
Main Authors:	Fokina, A. A., Kuznetsova, M. A., Repkova, M. N., Venyaminova, A. G.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis Group 01-10-2004
Subjects:	Base Sequence Catalysis DNA, Catalytic - chemistry DNA, Catalytic - metabolism DNA, Single-Stranded - chemistry DNA, Single-Stranded - metabolism Nucleic Acid Conformation Oligo(2′-O-methylribonucleotide) effector RNA cleavage Shortened DNAzyme Two-component 10-23 DNAzyme
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Description
Summary:	A new strategy for engineering of catalytic two-component constructions based on 10-23 DNAzyme was proposed. The using of a combination of shortened DNAzyme with 2′-O-methyl oligomers as effectors significantly increased the catalytic activity of this DNAzyme.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1525-7770 1532-2335
DOI:	10.1081/NCN-200026061