Minoxidil and male-pattern alopecia: a potential role for a local regulator of sebum secretion with vasoconstrictive effects?

Regulation of the hair cycle takes place at the pilo-sebaceous unit with the sebaceous gland as a sex hormone-dependent part. Although minoxidil stimulates proliferation of follicular cells and activation of prostaglandin endoperoxide synthase-1, it was suggested that other mechanisms, such as an in...

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Bibliographic Details
Published in:	Medical hypotheses Vol. 53; no. 5; pp. 402 - 406
Main Authors:	Kurbel, S., Kurbel, B., Žanić-Matanić, D.
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 01-11-1999 Elsevier
Subjects:	Alopecia - blood Alopecia - drug therapy Biological and medical sciences Endothelin-1 - pharmacology Estrogens - blood Humans Male Medical sciences Minoxidil - pharmacology Minoxidil - therapeutic use Models, Theoretical Pharmacology. Drug treatments Sebum - secretion Skin, nail, hair, dermoskeleton Testosterone - blood Vasoconstriction - drug effects Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use Human Skin disease Endothelin Secretion Peptide hormone Vasoconstriction Male Sebum Minoxidil Hair (head) Regulation(control) Treatment Piperidine derivatives Vasoconstrictor agent Mechanism of action Androgenetic alopecia
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