Thioredoxin is downstream of Smad7 in a pathway that promotes growth and suppresses cisplatin-induced apoptosis in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive human malignancy in which Smad7 is commonly overexpressed. Analysis by differential display identified thioredoxin-1 (TRX) as a gene whose basal expression is increased in COLO-357 pancreatic cancer cells engineered to overexpress Smad7. To de...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 64; no. 10; pp. 3599 - 3606
Main Authors:	ARNOLD, Nichole Boyer, KETTERER, Knut, KLEEFF, Jörg, FRIESS, Helmut, BÜCHLER, Markus W, KORC, Murray
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 15-05-2004
Subjects:	Antineoplastic agents Antineoplastic Agents - antagonists & inhibitors Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Division - physiology Cell Line, Tumor Cisplatin - antagonists & inhibitors Cisplatin - pharmacology DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Humans Medical sciences Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pharmacology. Drug treatments RNA, Messenger - biosynthesis RNA, Messenger - genetics Smad7 Protein Thioredoxins - biosynthesis Thioredoxins - genetics Trans-Activators - biosynthesis Trans-Activators - genetics Trans-Activators - physiology Transfection Tumors Antineoplastic agent Signal transduction Alkylating agent Cell death Pancreas cancer Digestive diseases Malignant tumor Thioredoxin Cisplatin Pancreatic disease Platinum II Complexes Apoptosis
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