HALP score and GNRI: Simple and easily accessible indexes for predicting prognosis in advanced stage NSCLC patients. The İzmir oncology group (IZOG) study

• Published in: Frontiers in nutrition (Lausanne) Vol. 9; p. 905292
• Main Authors: Güç, Zeynep Gülsüm, Alacacıoğlu, Ahmet, Kalender, Mehmet Eren, Oflazoğlu, Utku, Ünal, Sinan, Yıldız, Yaşar, Salman, Tarık, Küçükzeybek, Yüksel, Tarhan, Mustafa Oktay
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 18-08-2022
• Subjects: geriatric nutritional risk index (GNRI); hemoglobin-albumin-lymphocyte-platelet score; metastatic; non-small cell lung cancer; Nutrition; prognostic
• ISSN: 2296-861X; 2296-861X
• DOI: 10.3389/fnut.2022.905292

Objective
The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and the Geriatric Nutrition Risk Index (GNRI) are used as prognostic factors in different types of cancers. In this study we analyzed the prognostic value of the HALP Score and the GNRI calculated prior to first-line treatment in patients diagnosed with
de novo
metastatic non-small cell lung cancer (mNSCLC).
Materials and methods
De novo
mNSCLC patients were retrospectively evaluated from January 2016 to December 2019. Patients with Driver’s mutation, severe comorbidities, active infection, or insufficient organ function, and those receiving anti-inflammatory treatment were excluded from the study. Optimal cut-off points for the HALP score and the GNRI were calculated with the receiver operating characteristic (ROC) curve analysis. Predictive factors for overall survival (OS) were assessed with univariate and multivariate Cox proportional hazard analyses, and OS was studied with the Kaplan–Meier analysis.
Results
The study included 401 patients in total. In the ROC curve analysis, the cut-off points were found 23.24 (AUC = 0.928; 95% CI: 0.901–0.955,
p
< 0.001) for HALP, and 53.60 (AUC = 0.932; 95% CI: 0.908–0.955,
p
< 0.001) for GNRI. Groups with lower HALP scores and lower GNRI had significantly shorter OS compared to those with higher HALP scores and GNRIs. Univariate analysis showed that male gender, smoking, high ECOG score, low HALP score and low GNRI were associated with worse survival rates. Multivariate analysis showed that low HALP score (HR = 2.988, 95% CI: 2.065–4.324,
p
< 0.001); low GNRI score (HR = 2.901, 95% CI: 2.045–4.114,
p
< 0.001) and smoking history (HR = 1.447, 95% CI: 1.046–2.001,
p
= 0.025) were independent factors associated with worse OS rates.
Conclusion
Our study showed the HALP score and the GNRI to be of prognostic value as simple, cost-effective, and useful markers that predict OS in
de novo
mNSCLC patients.