Intracisternal Antisense Oligonucleotide to Growth Associated Protein-43 Blocks the Recovery-Promoting Effects of Basic Fibroblast Growth Factor after Focal Stroke

Focal infarction (stroke) of the lateral cerebral cortex of rats (including the sensorimotor cortex) produces deficits in sensorimotor function of the contralateral limbs that recover partially over time. In previous studies, we found that the intracisternal injection of basic fibroblast growth fact...

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Bibliographic Details
Published in:	Experimental neurology Vol. 158; no. 1; pp. 89 - 96
Main Authors:	Kawamata, Takakazu, Ren, JingMei, Cha, Jang-Ho, Finklestein, Seth P.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01-07-1999 Elsevier
Subjects:	Animals antisense oligonucleotide Axons - metabolism basic fibroblast growth factor behavioral recovery Biological and medical sciences Cerebral Cortex - pathology Cerebrovascular Disorders - pathology Cisterna Magna Drug Administration Routes Fibroblast Growth Factor 2 - antagonists & inhibitors GAP-43 GAP-43 Protein - metabolism Male Medical sciences Neuropharmacology Neuroprotective agent Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - pharmacokinetics Pharmacology. Drug treatments Psychomotor Performance - drug effects Rats Rats, Sprague-Dawley Recovery of Function - drug effects stroke Time Factors behavioral recovery antisense oligonucleotide stroke basic fibroblast growth factor GAP-43 Nervous system diseases Stroke Rat Intracisternal administration Rodentia Cardiovascular disease Basic fibroblast growth factor Antisense oligonucleotide Cerebral disorder Vascular disease Regeneration Vertebrata Chemotherapy Mammalia Treatment Animal Central nervous system disease Sensorimotor cortex Cerebrovascular disease
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