Chronic mild hyperhomocysteinemia induces anxiety-like symptoms, aversive memory deficits and hippocampus atrophy in adult rats: New insights into physiopathological mechanisms

•Increased levels of homocysteine are a marker for neurodegeneration.•Hcy caused anxiety-like behavior, long-term aversive memory deficits and hippocampal atrophy.•Molecular mechanisms involve oxidative stress and DNA damage in the hippocampus. In the last decade, increased homocysteine levels have...

Full description

Saved in:

Bibliographic Details
Published in:	Brain research Vol. 1728; p. 146592
Main Authors:	Wyse, A.T.S., Sanches, E.F., Dos Santos, T.M., Siebert, C., Kolling, J., Netto, C.A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-02-2020
Subjects:	Adenosine Triphosphate - metabolism Animals Anxiety - etiology Anxiety - pathology Atrophy - etiology Atrophy - pathology Avoidance Learning Behavior Chronic Disease DNA damage DNA Damage - physiology Electron Transport Complex IV - metabolism Hippocampal atrophy Hippocampus - pathology Hippocampus - physiopathology Homocysteine Homocysteine - blood Hyperhomocysteinemia - chemically induced Hyperhomocysteinemia - complications Long-term aversive memory Male Memory Disorders - etiology Memory Disorders - physiopathology Mild hyperhomocisteinemia Open Field Test Oxidative Stress - physiology Rats Rats, Wistar Mild hyperhomocisteinemia Behavior Homocysteine Long-term aversive memory DNA damage Hippocampal atrophy
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!