Dexamethasone sensitizes soluble guanylate cyclase in the rat renal glomeruli

We measured capability for guanosine 3',5'-cyclic monophosphate (cGMP) synthesis by isolated renal glomeruli from steroid-treated rats. Glomeruli obtained from animals treated with dexamethasone showed 5-fold higher sensitivity to sodium nitroprusside (SNP) than glomeruli from deoxycortico...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 197; no. 2; p. 826
Main Authors:	Lewko, B, Wendt, U, Stepinski, J, Angielski, S
Format:	Journal Article
Language:	English
Published:	United States 15-12-1993
Subjects:	1-Methyl-3-isobutylxanthine - pharmacology Animals Cyclic GMP - metabolism Cytosol - enzymology Desoxycorticosterone - pharmacology Dexamethasone - pharmacology Guanylate Cyclase - metabolism Kidney Glomerulus - drug effects Kidney Glomerulus - enzymology Kidney Glomerulus - metabolism Kinetics L-Lactate Dehydrogenase - analysis Male Nitroprusside - pharmacology Rats Rats, Wistar Reference Values
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