Up-regulation of P2X2, P2X4 receptor and ischemic cell death: Prevention by P2 antagonists

In the present work we examined the involvement of selected P2X receptors for extracellular ATP in the onset of neuronal cell death caused by glucose/oxygen deprivation. The in vitro studies of organotypic cultures from hippocampus evidenced that P2X2 and P2X4 were up-regulated by glucose/oxygen dep...

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Bibliographic Details
Published in:	Neuroscience Vol. 120; no. 1; pp. 85 - 98
Main Authors:	CAVALIERE, F, FLORENZANO, F, VOLONTE, C, AMADIO, S, FUSCO, F. R, VISCOMI, M. T, D'AMBROSI, N, VACCA, F, SANCESARIO, G, BERNARDI, G, MOLINARI, M
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier 01-08-2003
Subjects:	Animals Biological and medical sciences Cell Death - drug effects Cell Death - physiology Cell Hypoxia - drug effects Cell Hypoxia - physiology Gerbillinae Hippocampus - drug effects Hippocampus - metabolism Medical sciences Neurology Organ Culture Techniques Purinergic P2 Receptor Antagonists Rats Rats, Wistar Receptors, Purinergic P2 - biosynthesis Receptors, Purinergic P2X2 Receptors, Purinergic P2X4 Up-Regulation - drug effects Up-Regulation - physiology Vascular diseases and vascular malformations of the nervous system Nervous system diseases Neuroglia Rodentia Organotypic culture P2 Purinergic receptor Cardiovascular disease Cerebral disorder Microglia Vascular disease carotid occlusion Vertebrata Experimental disease Mammalia Ischemia Cell death Animal Central nervous system disease Antagonist organotypic cultures Gerbil Cerebrovascular disease Brain (vertebrata)
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