Coagulation in Vertebrates with a Focus on Evolution and Inflammation

The evolution of a thrombin-generating system that produces a gelatinous clot to prevent the loss of blood occurred in parallel with the evolution of inflammatory responses that depend on bradykinin generation. Bioinformatics approaches that inventory the presence or absence of genes involved in the...

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Bibliographic Details
Published in:	Journal of innate immunity Vol. 3; no. 1; pp. 9 - 16
Main Author:	Doolittle, Russell F.
Format:	Journal Article
Language:	English
Published:	Basel, Switzerland S. Karger AG 01-01-2011
Subjects:	Animals Blood Coagulation - genetics Blood Coagulation Factors - genetics Evolution, Molecular Fishes - genetics Fishes - physiology Humans Inflammation Mammals - genetics Mammals - physiology Review Vertebrates - genetics Vertebrates - physiology Vertebrates Evolution Inflammation Contact phase Protochordates Clotting
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Summary:	The evolution of a thrombin-generating system that produces a gelatinous clot to prevent the loss of blood occurred in parallel with the evolution of inflammatory responses that depend on bradykinin generation. Bioinformatics approaches that inventory the presence or absence of genes involved in these two processes support the view that both became progressively more complex during the period between the divergence of jawless fish and the appearance of mammals. Although the roots of both systems may extend to protochordates, they arose quite independently.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1662-811X 1662-8128
DOI:	10.1159/000321005