Ins and Outs of Kinase DFG Motifs

In this issue of Chemistry & Biology, Hari and colleagues show that two positions in kinase active sites, including the well-known “gatekeeper” residue, regulate “in” versus “out” conformations of the conserved “DFG” motif. These findings suggest yet another role for the gatekeeper residue....

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Bibliographic Details
Published in:	Chemistry & biology Vol. 20; no. 6; pp. 745 - 746
Main Authors:	Treiber, Daniel K., Shah, Neil P.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 20-06-2013
Subjects:	Mitogen-Activated Protein Kinases - metabolism
Online Access:	Get full text
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Summary:	In this issue of Chemistry & Biology, Hari and colleagues show that two positions in kinase active sites, including the well-known “gatekeeper” residue, regulate “in” versus “out” conformations of the conserved “DFG” motif. These findings suggest yet another role for the gatekeeper residue.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1
ISSN:	1074-5521 1879-1301
DOI:	10.1016/j.chembiol.2013.06.001