Amylin Modulates a Ventral Tegmental Area–to–Medial Prefrontal Cortex Circuit to Suppress Food Intake and Impulsive Food-Directed Behavior

A better understanding of the neural mechanisms regulating impaired satiety to palatable foods is essential to treat hyperphagia linked with obesity. The satiation hormone amylin signals centrally at multiple nuclei including the ventral tegmental area (VTA). VTA–to–medial prefrontal cortex (mPFC) p...

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Bibliographic Details
Published in:	Biological psychiatry (1969) Vol. 95; no. 10; pp. 938 - 950
Main Authors:	Geisler, Caroline E., Décarie-Spain, Léa, Loh, Maxine K., Trumbauer, Wolf, Gaisinsky, Jane, Klug, Molly E., Pelletier, Caitlyn, Davis, Jon F., Schmidt, Heath D., Roitman, Mitchell F., Kanoski, Scott E., Hayes, Matthew R.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 15-05-2024
Subjects:	Amylin Animals Dopamine - metabolism Eating - drug effects Eating - physiology Feeding Behavior - drug effects Feeding Behavior - physiology Impulsive Behavior - drug effects Impulsive Behavior - physiology Impulsivity Islet Amyloid Polypeptide - pharmacology Male Neural Pathways - drug effects Neural Pathways - physiology Obesity Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Prefrontal Cortex - physiology Rats Rats, Sprague-Dawley Receptors, Calcitonin - metabolism Reward Ventral tegmental area Ventral Tegmental Area - drug effects Ventral Tegmental Area - metabolism Ventral Tegmental Area - physiology Obesity Impulsivity Prefrontal cortex Reward Ventral tegmental area Amylin
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