The effect of copaiba balsam on Walker 256 carcinoma inoculated into the vagina and uterine cervix of female rats

• Published in: Acta cirurgica brasileira Vol. 25; no. 2; pp. 176 - 180
• Main Authors: Brito, Nara Macedo Botelho, Brito, Marcus Vinicius Henriques, Carvalho, Rita de Kássia Vidigal, Matos, Lia Tavares de Moura Brasil, Lobato, Rodolfo Costa, Correa, Suelen Costa, Brito, Rosângela Baía
• Format: Journal Article
• Language: English
• Published: Brazil 01-04-2010
• Subjects: Animals; Antineoplastic Agents, Phytogenic - therapeutic use; Balsams - therapeutic use; Carcinoma 256, Walker - drug therapy; Carcinoma 256, Walker - pathology; Drug Screening Assays, Antitumor - methods; Female; Phytotherapy; Rats; Rats, Wistar; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - pathology; Vaginal Neoplasms - drug therapy; Vaginal Neoplasms - pathology
• ISSN: 0102-8650; 1678-2674; 0102-8650
• DOI: 10.1590/S0102-86502010000200010

To verify the copaiba balsam (Copaifera officinalis) effect on Walker 256 carcinoma inoculated into vagina and uterine cervix of rats.
Eighteen female Wistar rats weighing between 180-250g were used, distributed into 2 groups (GCop, GC). On the 1st day of the experiment, 0.3 ml of Walker 256 carcinoma (2x10(6) concentration) was inoculated in both groups; on the 3rd day of the experiment, it was given 4.8 ml/kg of distilled water to the GC group, and 4.8 ml/kg of copaiba balsam to the GCop group. On the 12th day, euthanasia was performed and the tumor was grafted, being weighted and verified its volume. The data were submitted to statistical analysis with ANOVA test.
It was observed that copaiba balsam presented a negative inhibitory potential of 70%.
The copaiba balsam stimulated the tumor growth.