Dysregulated expression of CD69 and IL‐2 receptor α and β chains on CD8+ T lymphocytes in flaky skin mice

T‐cell activation is considered to be an important element in the pathogenesis of psoriasis, a human skin disease characterized by keratinocyte hyperproliferation, altered keratinocyte differentiation and inflammation of the dermis and epidermis. Mice homozygous for the flaky skin (fsn) mutation dev...

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Bibliographic Details
Published in:	Immunology and cell biology Vol. 78; no. 6; pp. 596 - 602
Main Authors:	Abernethy, Nevin J, Hagan, Colin, Tan, Paul LJ, Watson, James D
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01-12-2000
Subjects:	Animals Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - immunology CD122 CD25 CD3 Complex - immunology CD69 CD8-Positive T-Lymphocytes - immunology Female Flow Cytometry interleukin‐2 receptor Lectins, C-Type Lymph Nodes - immunology lymphadenopathy Lymphocyte Activation Male Mice Mice, Inbred BALB C Mice, Mutant Strains psoriasis Psoriasis - immunology Receptors, Interleukin-2 - biosynthesis T‐cell activation Up-Regulation
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