Malignant peripheral nerve sheath tumour in a dog presenting as a pseudo aneurysm of the left jugular vein: a case report

• Published in: Veterinární medicína Vol. 53; no. 12; pp. 685 - 689
• Main Authors: Kostov, M., Mijovic, Z., Visnjic, M., Mihailovic, D., Stojanovic, M., Zdravkovic, M.
• Format: Journal Article
• Language: English
• Published: Prague Czech Academy of Agricultural Sciences (CAAS) 01-12-2008; Czech Academy of Agricultural Sciences
• Subjects: Aneurysm; Aneurysms; Animal behavior; Autopsies; Autopsy; Case reports; dog; Dogs; Dyspnea; Immunohistochemistry; Jugular vein; malignant peripheral nerve sheath tumour; Morphology; Peripheral nerves; Respiration; S100 protein; Sheaths; Signs and symptoms; Tumors; tumour; Veins; Vertebrae; Weight loss
• ISSN: 0375-8427; 1805-9392
• DOI: 10.17221/1976-VETMED

The authors report an autopsy case of a malignant peripheral nerve sheath tumour in a 9-year-old female Akito-ino dog, presenting as a pseudo aneurysm of the left jugular vein. Signs and symptoms included swelling of the neck and legs, dyspnea, malaise and weight loss. Post-mortem examination revealed a tumour mass (8 × 6, 5 × 6 cm), localized to the left paravertebrally, and on the level of C7 to T2 vertebral bodies; additional masses were observed in both lungs, heart and left kidney. On the basis of necropsy, histological findings and immunophenotype, the tumour was classsified as a malignant peripheral nerve sheath tumour. Immunohistochemistry especially positivity for S-100 protein can be helpful in distinguishing this type of neoplasm from other malignancies with similar morphologies.