TAMEC: a new analogue of cyclomyrsinol diterpenes decreases anxiety- and depression-like behaviors in a mouse model of multiple sclerosis

There is a significant prevalence of affective disorders including depression and anxiety in people with multiple sclerosis (MS), resulting in reduced quality of life. Since the current treatments are not generally effective, further studies are needed to find appropriate drugs to alleviate anxiety...

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Bibliographic Details
Published in:	Neurological research (New York) Vol. 39; no. 12; pp. 1056 - 1065
Main Authors:	Ayatollahi, Abdul Majid, Haji Molla Hoseini, Mostafa, Ghanadian, Syed Mustafa, Kosari-Nasab, Morteza, Mami, Fatemeh, Yazdiniapoure, Zeinab, Zolfaghari, Behzad, Salari, Ali-Akbar
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 02-12-2017
Subjects:	Animals anxiety Anxiety - drug therapy Anxiety - physiopathology Cyclomyrsinol diterpenes depression Depression - drug therapy Depression - physiopathology Disease Models, Animal Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology EAE Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - physiopathology Encephalomyelitis, Autoimmune, Experimental - psychology Female Hippocampus - drug effects Hippocampus - metabolism Interleukin-10 - metabolism Interleukin-1beta - metabolism Mice, Inbred C57BL Molecular Structure Psychotropic Drugs - chemistry Psychotropic Drugs - isolation & purification Psychotropic Drugs - pharmacology Tumor Necrosis Factor-alpha - metabolism Cyclomyrsinol diterpenes EAE anxiety depression
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