Characterization of the specific meningeal T cell response to intracerebral inoculation of Theiler's murine encephalomyelitis virus

Characterization of the specific meningeal T cell response to intracerebral inoculation of Theiler's murine encephalomyelitis virus

The presence of a resident T lymphocyte population in the meninges of normal SJL/J mice has been detected by the use of the T cell-specific mitogen concanavalin A. Optimal conditions for [3H]thymidine incorporation were studied. An antigen-specific meningeal T cell proliferative response in SJL/J mi...

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Bibliographic Details
Published in:Journal of neuroimmunology Vol. 31; no. 3; p. 229
Main Authors: Scheu, A K, Rubio, N
Format: Journal Article
Language:English
Published: Netherlands 01-03-1991
Subjects:
Animals
Antigens - immunology
Cell Separation
Concanavalin A - pharmacology
Demyelinating Diseases - etiology
Lymphocyte Activation
Maus Elberfeld virus - immunology
Meninges - immunology
Mice
T-Lymphocytes - immunology
Thymidine - metabolism
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Summary:The presence of a resident T lymphocyte population in the meninges of normal SJL/J mice has been detected by the use of the T cell-specific mitogen concanavalin A. Optimal conditions for [3H]thymidine incorporation were studied. An antigen-specific meningeal T cell proliferative response in SJL/J mice, primed by intracerebral inoculation of Theiler's murine encephalomyelitis virus, was also detected. This response indicated that leptomeningeal mononuclear cell infiltrations are involved in the immune response that triggers the demyelinating disease.
ISSN:0165-5728
DOI:10.1016/0165-5728(91)90044-8