Early Stage Breast Cancer: Does Histologic Subtype (Ductal vs. Lobular) Impact 5 Year Overall Survival?
Histology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer patients. We studied 11,085 breast cancer patients diagnosed with T1-T2 tumors, clinically node-negative and non-metastatic, from 2004 to 2019 i...
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| Published in: | Cancers Vol. 16; no. 8; p. 1509 |
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| Abstract | Histology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer patients. We studied 11,085 breast cancer patients diagnosed with T1-T2 tumors, clinically node-negative and non-metastatic, from 2004 to 2019 included in the National Cancer Database. Kaplan-Meier curves, log-rank tests and Cox regression models were used to study the impact of histology and other variables on OS. In our patient population, 8678 (78.28%) had ductal cancer (IDC), while 2407 (21.71%) had lobular cancer (ILC). ILC patients were significantly more likely to be older, Caucasian, have a lower grade at diagnosis and be hormone receptor-positive compared to IDC patients. There was no statistically significant difference in the 5-year OS of early stage ductal (16.8%) and lobular cancer patients (16.7%) (
= 0.200). Patients of Hispanic and African American origin had worse OS rates compared to non-Hispanic and Caucasian patients, respectively. For node-positive disease, HER2+ tumors and triple-negative tumors, chemotherapy had a positive influence on OS (HR 0.85, 95% CI 0.77-0.93,
= 0.0012). Histology did not have a significant impact on the 5-year OS of early stage breast cancer patients. |
|---|---|
| AbstractList | Histology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer patients. We studied 11,085 breast cancer patients diagnosed with T1–T2 tumors, clinically node-negative and non-metastatic, from 2004 to 2019 included in the National Cancer Database. Kaplan–Meier curves, log-rank tests and Cox regression models were used to study the impact of histology and other variables on OS. In our patient population, 8678 (78.28%) had ductal cancer (IDC), while 2407 (21.71%) had lobular cancer (ILC). ILC patients were significantly more likely to be older, Caucasian, have a lower grade at diagnosis and be hormone receptor-positive compared to IDC patients. There was no statistically significant difference in the 5-year OS of early stage ductal (16.8%) and lobular cancer patients (16.7%) (p = 0.200). Patients of Hispanic and African American origin had worse OS rates compared to non-Hispanic and Caucasian patients, respectively. For node-positive disease, HER2+ tumors and triple-negative tumors, chemotherapy had a positive influence on OS (HR 0.85, 95% CI 0.77–0.93, p = 0.0012). Histology did not have a significant impact on the 5-year OS of early stage breast cancer patients. Simple SummaryThe two major histological subtypes of breast cancer are ductal and lobular cancers. Histology impacts the biological behavior of breast cancer, so it is imperative to study its influence on the overall survival of breast cancer patients. The existing literature reports conflicting conclusions regarding the impact that histology might have on survival, so we aimed to study a large sample of patient data obtained from the National Cancer Database to determine if histology and several other clinical factors have an impact on the survival of early-stage breast cancer patients who have T1–T2 tumors, are clinically node-negative and have no metastatic activity. These results may help clinicians better understand the behaviors of different subtypes of breast cancer and will help them take a more tailored approach to breast cancer treatment.AbstractHistology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer patients. We studied 11,085 breast cancer patients diagnosed with T1–T2 tumors, clinically node-negative and non-metastatic, from 2004 to 2019 included in the National Cancer Database. Kaplan–Meier curves, log-rank tests and Cox regression models were used to study the impact of histology and other variables on OS. In our patient population, 8678 (78.28%) had ductal cancer (IDC), while 2407 (21.71%) had lobular cancer (ILC). ILC patients were significantly more likely to be older, Caucasian, have a lower grade at diagnosis and be hormone receptor-positive compared to IDC patients. There was no statistically significant difference in the 5-year OS of early stage ductal (16.8%) and lobular cancer patients (16.7%) (p = 0.200). Patients of Hispanic and African American origin had worse OS rates compared to non-Hispanic and Caucasian patients, respectively. For node-positive disease, HER2+ tumors and triple-negative tumors, chemotherapy had a positive influence on OS (HR 0.85, 95% CI 0.77–0.93, p = 0.0012). Histology did not have a significant impact on the 5-year OS of early stage breast cancer patients. Histology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer patients. We studied 11,085 breast cancer patients diagnosed with T1-T2 tumors, clinically node-negative and non-metastatic, from 2004 to 2019 included in the National Cancer Database. Kaplan-Meier curves, log-rank tests and Cox regression models were used to study the impact of histology and other variables on OS. In our patient population, 8678 (78.28%) had ductal cancer (IDC), while 2407 (21.71%) had lobular cancer (ILC). ILC patients were significantly more likely to be older, Caucasian, have a lower grade at diagnosis and be hormone receptor-positive compared to IDC patients. There was no statistically significant difference in the 5-year OS of early stage ductal (16.8%) and lobular cancer patients (16.7%) ( = 0.200). Patients of Hispanic and African American origin had worse OS rates compared to non-Hispanic and Caucasian patients, respectively. For node-positive disease, HER2+ tumors and triple-negative tumors, chemotherapy had a positive influence on OS (HR 0.85, 95% CI 0.77-0.93, = 0.0012). Histology did not have a significant impact on the 5-year OS of early stage breast cancer patients. |
| Author | Ahmed, Syeda Hoorulain Sharan, Seema Popp, Kyle Sukniam, Kulkaew B Gabriel, Emmanuel Mubarak, Fatima Popp, Reed Raikot, Swathi R Jimenez, Paola Berrios Manaise, Harsheen K Bansal, Shivam Kowkabany, Gabrielle |
| Author_xml | – sequence: 1 givenname: Fatima surname: Mubarak fullname: Mubarak, Fatima organization: The Aga Khan University Medical College, Stadium Road, P.O. Box 3500, Karachi 74800, Sindh, Pakistan – sequence: 2 givenname: Gabrielle surname: Kowkabany fullname: Kowkabany, Gabrielle organization: Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL 35487, USA – sequence: 3 givenname: Reed surname: Popp fullname: Popp, Reed organization: University of Florida College of Medicine, 1600 SW Archer Rd, Gainesville, FL 32610, USA – sequence: 4 givenname: Shivam surname: Bansal fullname: Bansal, Shivam organization: Government Medical College & Hospital, Block C, 1157-B, Chandi Path, 32B, Sector 32, Chandigarh 160047, India – sequence: 5 givenname: Syeda Hoorulain orcidid: 0000-0002-8234-2586 surname: Ahmed fullname: Ahmed, Syeda Hoorulain organization: Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, FL 32608, USA – sequence: 6 givenname: Seema surname: Sharan fullname: Sharan, Seema organization: Government Medical College & Hospital, Block C, 1157-B, Chandi Path, 32B, Sector 32, Chandigarh 160047, India – sequence: 7 givenname: Kulkaew B surname: Sukniam fullname: Sukniam, Kulkaew B organization: Duke University Medical Center, 10 Duke Medicine Cir, Durham, NC 27710, USA – sequence: 8 givenname: Swathi R surname: Raikot fullname: Raikot, Swathi R organization: Emory University, 201 Dowman Dr, Atlanta, GA 30322, USA – sequence: 9 givenname: Paola Berrios surname: Jimenez fullname: Jimenez, Paola Berrios organization: University of Puerto Rico, 6, 2526, 601 Av. Universidad, San Juan, PR 00925, USA – sequence: 10 givenname: Kyle surname: Popp fullname: Popp, Kyle organization: Florida State University, 600 W College Ave, Tallahassee, FL 32306, USA – sequence: 11 givenname: Harsheen K surname: Manaise fullname: Manaise, Harsheen K organization: Government Medical College & Hospital, Block C, 1157-B, Chandi Path, 32B, Sector 32, Chandigarh 160047, India – sequence: 12 givenname: Emmanuel orcidid: 0000-0001-8570-4784 surname: Gabriel fullname: Gabriel, Emmanuel organization: Department of General Surgery, Division of Surgical Oncology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA |
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| Cites_doi | 10.1001/jamanetworkopen.2023.42270 10.1177/1527154420965537 10.1056/NEJMoa050518 10.3390/cancers13153695 10.1007/s10549-010-1191-6 10.1016/j.breast.2013.06.001 10.1158/1078-0432.CCR-10-1533 10.3892/mco.2015.625 10.3390/ijerph14050486 10.1002/1097-0142(20000601)88:11<2561::AID-CNCR19>3.0.CO;2-X 10.1186/bcr767 10.1089/jwh.2012.4235 10.1016/S0140-6736(05)66544-0 10.3390/ijerph20042903 10.1186/s12885-016-2275-4 10.4137/CPath.S31563 10.1007/s00404-008-0662-z 10.1016/j.ejca.2007.10.009 10.1097/AS9.0000000000000405 10.1093/jnci/djac157 10.3390/cancers15225491 10.1200/JCO.2007.14.9336 10.1093/annonc/mds180 10.1245/s10434-011-1907-9 10.1177/002215540305101112 10.21873/anticanres.16088 10.1016/j.breast.2021.07.011 10.1245/s10434-010-0953-z 10.1001/jamaoncol.2017.5906 10.1371/journal.pone.0132853 10.1177/146642400212200118 10.1002/onco.13734 10.3389/fonc.2020.590643 |
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| Snippet | Histology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer... Simple SummaryThe two major histological subtypes of breast cancer are ductal and lobular cancers. Histology impacts the biological behavior of breast cancer,... |
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| SubjectTerms | Breast cancer Breath tests Cancer therapies Chemotherapy ErbB-2 protein Estrogens Histology Hormone replacement therapy Medical prognosis Metastases Metastasis Older people Patients Radiation Regression analysis Statistical analysis Survival Tumors Variables Womens health |
| Title | Early Stage Breast Cancer: Does Histologic Subtype (Ductal vs. Lobular) Impact 5 Year Overall Survival? |
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