Poly(lactic acid)/β-cyclodextrin based nanoparticles bearing ruthenium(II)-arene naproxen complex: preparation and characterisation. Analytical validation for metal determination by microwave-induced plasma optical emission spectrometry

The objectives of this work are to develop nanocarrier systems for the Ru(II)-p-cymene naproxen antitumor metallodrug, [Ru(η 6 -p-cymene)(npx)Cl] or Rupcy, based on polymeric nanoparticles (NPs) composed by the biodegradable poly(lactic acid) (PLA) and the hydrophilic polymerised β-cyclodextrin (Pol...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of microencapsulation Vol. 40; no. 2; pp. 67 - 81
Main Authors:	Reis Nascimento, Ruan, Pauline Gaitan Tabares, Julie, Marques dos Anjos, Paulo Neilson, Santos, Luana Novaes, de Oliveira Silva, Denise, Silva Ribeiro Santos, Rodrigo Luis
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 17-02-2023
Subjects:	anti-inflammatory drugs biodegradable polymers Drug Carriers - chemistry drug delivery systems Metallodrug microwave-induced plasma Microwaves Nanoparticles - chemistry Naproxen Particle Size Polyesters - chemistry Polymers - chemistry Ruthenium Spectrum Analysis drug delivery systems microwave-induced plasma anti-inflammatory drugs Metallodrug biodegradable polymers
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	The objectives of this work are to develop nanocarrier systems for the Ru(II)-p-cymene naproxen antitumor metallodrug, [Ru(η 6 -p-cymene)(npx)Cl] or Rupcy, based on polymeric nanoparticles (NPs) composed by the biodegradable poly(lactic acid) (PLA) and the hydrophilic polymerised β-cyclodextrin (PolyCD); to validate an analytical method for determination of Ru incorporated into the metallodrug loaded-NPs. The PolyCD was prepared by single step condensation and polymerisation reaction and incorporated as a polymer blend during the fabrication of PLA/PolyCD blends NPs and also as a core/shell structure built by adsorption of the PolyCD onto the surface of PLA NPs to give PLA(core)/PolyCD(shell) NPs. Three different loaded-systems incorporating the metallodrug (Rupcy-PLA NPs (1), Rupcy-PLA/PolyCD blends (2), and Rupcy-PLA(core)/PolyCD(shell) NPs (3)) were prepared by nanoprecipitation. The characterisation was performed by Proton Nuclear Magnetic Resonance, Matrix Assisted Laser Desorption/Ionization Time-of-Flight, Fourier-Transform Infra-red and UV-VIS Electronic Absorption Spectroscopies, Thermogravimetric Analysis, Differential Scanning Calorimetry, Dynamic Light Scattering, and Electrophoretic Light Scattering. Ru was determined by Microwave Induced Plasma Optical Emission Spectrometry (MIP-OES) with validation of the method. The metallodrug entrapment efficiency was around 90% (w/w) and drug loading was at 3-4% (w/w). The characterised metallodrug-loaded systems exhibited monomodal size distributions and appropriate hydrodynamic diameters [218.3 ± 13.5 (1), 205.4 ± 14.4 (2), 231.5 ± 22.0 (3) nm] and zeta potential values [−31.5 ± 2.2 (1), −26.1 ± 4.5 (2), −28.8 ± 6.1 (3) mV]. The validation of the MIP-OES method by evaluating selectivity, linearity, precision, accuracy, and limits of detection and quantification succeeded. The NPs parameters are compatible with colloidally stable systems. The MIP-OES method showed to be simple, reliable, and feasible to quantify indirectly the amount of the metallodrug-loaded into the PLA NPs.
AbstractList	The objectives of this work are to develop nanocarrier systems for the Ru(II)-p-cymene naproxen antitumor metallodrug, [Ru(η 6 -p-cymene)(npx)Cl] or Rupcy, based on polymeric nanoparticles (NPs) composed by the biodegradable poly(lactic acid) (PLA) and the hydrophilic polymerised β-cyclodextrin (PolyCD); to validate an analytical method for determination of Ru incorporated into the metallodrug loaded-NPs. The PolyCD was prepared by single step condensation and polymerisation reaction and incorporated as a polymer blend during the fabrication of PLA/PolyCD blends NPs and also as a core/shell structure built by adsorption of the PolyCD onto the surface of PLA NPs to give PLA(core)/PolyCD(shell) NPs. Three different loaded-systems incorporating the metallodrug (Rupcy-PLA NPs (1), Rupcy-PLA/PolyCD blends (2), and Rupcy-PLA(core)/PolyCD(shell) NPs (3)) were prepared by nanoprecipitation. The characterisation was performed by Proton Nuclear Magnetic Resonance, Matrix Assisted Laser Desorption/Ionization Time-of-Flight, Fourier-Transform Infra-red and UV-VIS Electronic Absorption Spectroscopies, Thermogravimetric Analysis, Differential Scanning Calorimetry, Dynamic Light Scattering, and Electrophoretic Light Scattering. Ru was determined by Microwave Induced Plasma Optical Emission Spectrometry (MIP-OES) with validation of the method. The metallodrug entrapment efficiency was around 90% (w/w) and drug loading was at 3-4% (w/w). The characterised metallodrug-loaded systems exhibited monomodal size distributions and appropriate hydrodynamic diameters [218.3 ± 13.5 (1), 205.4 ± 14.4 (2), 231.5 ± 22.0 (3) nm] and zeta potential values [−31.5 ± 2.2 (1), −26.1 ± 4.5 (2), −28.8 ± 6.1 (3) mV]. The validation of the MIP-OES method by evaluating selectivity, linearity, precision, accuracy, and limits of detection and quantification succeeded. The NPs parameters are compatible with colloidally stable systems. The MIP-OES method showed to be simple, reliable, and feasible to quantify indirectly the amount of the metallodrug-loaded into the PLA NPs. The objectives of this work are to develop nanocarrier systems for the Ru(II)-p-cymene naproxen antitumor metallodrug, [Ru(η -p-cymene)(npx)Cl] or Rupcy, based on polymeric nanoparticles (NPs) composed by the biodegradable poly(lactic acid) (PLA) and the hydrophilic polymerised β-cyclodextrin (PolyCD); to validate an analytical method for determination of Ru incorporated into the metallodrug loaded-NPs. The PolyCD was prepared by single step condensation and polymerisation reaction and incorporated as a polymer blend during the fabrication of PLA/PolyCD blends NPs and also as a core/shell structure built by adsorption of the PolyCD onto the surface of PLA NPs to give PLA(core)/PolyCD(shell) NPs. Three different loaded-systems incorporating the metallodrug (Rupcy-PLA NPs ( ), Rupcy-PLA/PolyCD blends ( ), and Rupcy-PLA(core)/PolyCD(shell) NPs ( )) were prepared by nanoprecipitation. The characterisation was performed by Proton Nuclear Magnetic Resonance, Matrix Assisted Laser Desorption/Ionization Time-of-Flight, Fourier-Transform Infra-red and UV-VIS Electronic Absorption Spectroscopies, Thermogravimetric Analysis, Differential Scanning Calorimetry, Dynamic Light Scattering, and Electrophoretic Light Scattering. Ru was determined by Microwave Induced Plasma Optical Emission Spectrometry (MIP-OES) with validation of the method. The metallodrug entrapment efficiency was around 90% (w/w) and drug loading was at 3-4% (w/w). The characterised metallodrug-loaded systems exhibited monomodal size distributions and appropriate hydrodynamic diameters [218.3 ± 13.5 ( ), 205.4 ± 14.4 ( ), 231.5 ± 22.0 ( ) nm] and zeta potential values [-31.5 ± 2.2 ( ), -26.1 ± 4.5 ( ), -28.8 ± 6.1 ( ) mV]. The validation of the MIP-OES method by evaluating selectivity, linearity, precision, accuracy, and limits of detection and quantification succeeded. The NPs parameters are compatible with colloidally stable systems. The MIP-OES method showed to be simple, reliable, and feasible to quantify indirectly the amount of the metallodrug-loaded into the PLA NPs.
Author	Reis Nascimento, Ruan Santos, Luana Novaes de Oliveira Silva, Denise Silva Ribeiro Santos, Rodrigo Luis Pauline Gaitan Tabares, Julie Marques dos Anjos, Paulo Neilson
Author_xml	– sequence: 1 givenname: Ruan surname: Reis Nascimento fullname: Reis Nascimento, Ruan organization: Department of Exact and Technological Sciences, State University of Santa Cruz – sequence: 2 givenname: Julie surname: Pauline Gaitan Tabares fullname: Pauline Gaitan Tabares, Julie organization: Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo – sequence: 3 givenname: Paulo Neilson surname: Marques dos Anjos fullname: Marques dos Anjos, Paulo Neilson organization: Department of Exact and Technological Sciences, State University of Santa Cruz – sequence: 4 givenname: Luana Novaes surname: Santos fullname: Santos, Luana Novaes organization: Department of Exact and Technological Sciences, State University of Santa Cruz – sequence: 5 givenname: Denise surname: de Oliveira Silva fullname: de Oliveira Silva, Denise organization: Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo – sequence: 6 givenname: Rodrigo Luis orcidid: 0000-0002-5063-7451 surname: Silva Ribeiro Santos fullname: Silva Ribeiro Santos, Rodrigo Luis organization: Department of Exact and Technological Sciences, State University of Santa Cruz
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/36722704$$D View this record in MEDLINE/PubMed
BookMark	eNp9kc9u1DAQxi1URLeFRwD5uD1k6zjOn-VEVUFZqRIc4BxN7Ak1cuxgO-3mtfogvAnvUC_ZcuRkzcxvvhnPd0ZOrLNIyNucbXLWsEvGq5Iz0Ww448WG5zUX1fYFWeWiElmZghOyOjDZATolZyH8ZIyV24a_IqdFVXNeM7Eif746M68NyKglBanVxeXvx0zO0jiF--i1pR0EVNSCdSP4hBkMtENIpR_UT_EOrZ6G9W53kYFHi4kcvdujpdINo8H9ezp6TK0QtbMUrKLyLkUyotfhb3JDryyYOWmDofdgtFrY3nk6YExJhYketF3y3UwHLb17gHvMtFWTTAuOBsIA1I2LDA46hAMcRpTRu6Tj59fkZQ8m4Jvje06-f_r47fpzdvvlZnd9dZvJoqpiBgU2omFsi2VdSWgEAGM1V03NpGBCYCG6Mq8a5Ng0fSm5LPOuYLXKu7zrq7I4J-tFN13i14QhtmkbicaARTeFltd1XhV1siCh5YKm_4TgsW9Hrwfwc5uz9uB0--x0e3C6PTqd-t4dR0zdgOpf17O1CfiwANqmOw7w4LxRbYTZON97sFKHtvj_jCe0YsHO
CitedBy_id	crossref_primary_10_1016_j_ica_2024_122060 crossref_primary_10_1080_02652048_2023_2258967
Cites_doi	10.1590/S0100-40422004000500017 10.1039/C7NR01582H 10.1016/j.colsurfb.2013.09.035 10.1166/jnn.2016.12084 10.1002/app.51504 10.1016/j.colsurfb.2020.111305 10.2174/1567201817666200512104833 10.1016/j.ijpharm.2005.02.039 10.1039/C4CS00487F 10.1016/j.jinorgbio.2019.110984 10.1016/j.addr.2016.05.020 10.1021/cr970019t 10.1016/0928-0987(93)90023-4 10.1039/C7DT03637J 10.1016/j.xphs.2018.03.021 10.3390/ph12040146 10.1007/s00775-014-1143-4 10.1002/masy.19971220136 10.1016/j.ccr.2016.01.001 10.2174/187152010791162333 10.1007/s10847-011-0024-5 10.2147/DDDT.S119488 10.3109/02652040903131301 10.1016/j.poly.2007.12.011 10.1038/nbt.3330 10.1016/j.carbpol.2016.01.046 10.1016/j.ijpharm.2021.120571 10.1080/00032719908542934 10.1080/10408398.2014.970267 10.1111/j.2044-8317.1997.tb01147.x 10.1016/j.trac.2012.12.015 10.1016/j.polymer.2011.06.043 10.1016/j.msec.2017.06.004 10.1016/j.colsurfb.2009.09.001 10.1007/s00396-019-04572-9 10.1016/j.eurpolymj.2020.110155 10.1002/mabi.200700022 10.1016/j.tca.2007.12.009 10.1016/j.addr.2016.05.002 10.1016/j.ijpharm.2017.11.001 10.1016/j.polymer.2006.04.013 10.3390/inorganics7010002 10.3390/bios10120196 10.1016/j.ijpharm.2017.11.018 10.1016/S0014-3057(96)00123-1 10.1016/j.ijpharm.2012.07.052 10.1016/j.carbpol.2020.116277 10.1016/j.poly.2012.05.012 10.1016/j.ica.2019.01.030 10.1016/j.ijbiomac.2014.08.012 10.1016/j.carbpol.2017.05.086 10.1016/j.jchromb.2008.09.030 10.1016/S0731-7085(02)00142-5 10.1016/j.aca.2014.04.057 10.1016/j.poly.2020.114827 10.1016/j.jconrel.2016.11.025 10.1016/j.msec.2015.11.019 10.1039/C3DT52388H 10.1016/j.msec.2016.09.080 10.1016/j.jinorgbio.2016.10.003 10.1021/ac961912f 10.1016/j.talanta.2003.12.014 10.1016/j.jpba.2017.06.034 10.1016/S0168-3659(02)00127-X 10.1016/j.foodchem.2012.11.074 10.1002/jps.2600801214 10.1016/j.talanta.2013.11.043 10.1016/j.actbio.2015.11.031 10.1016/j.jpba.2004.06.016 10.1016/j.carbpol.2019.05.027 10.1351/pac199971020337 10.1016/j.carbpol.2016.02.043 10.1016/j.ijpharm.2019.05.042 10.1016/j.jconrel.2008.08.012 10.1016/j.foodchem.2016.03.083 10.1016/j.mtchem.2018.05.002
ContentType	Journal Article
Copyright	2023 Informa UK Limited, trading as Taylor & Francis Group 2023
Copyright_xml	– notice: 2023 Informa UK Limited, trading as Taylor & Francis Group 2023
DBID	CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8
DOI	10.1080/02652048.2023.2172469
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic
DatabaseTitleList	MEDLINE
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Pharmacy, Therapeutics, & Pharmacology
EISSN	1464-5246
EndPage	81
ExternalDocumentID	10_1080_02652048_2023_2172469 36722704 2172469
Genre	Research Articles Journal Article
GroupedDBID	--- 00X 03L 0BK 0R~ 29L 36B 4.4 53G 5GY AAJNR AALUX AAMIU AAPUL AAPXX AAQRR ABBKH ABDBF ABEIZ ABLKL ABPTK ABUPF ACENM ACFUF ACGEJ ACGFS ACLSK ADCVX ADFCX ADNWM ADRBQ ADXPE AECIN AENEX AEOZL AEYQI AFKVX AFWLO AGDLA AGFJD AGRBW AGYJP AIJEM AIRBT AJWEG AKBVH ALIIL ALMA_UNASSIGNED_HOLDINGS ALQZU AMDAE BABNJ BLEHA BOHLJ CCCUG CS3 DKSSO DU5 EAP EBS EHN ESX F5P H13 HZ~ J.N KRBQP KWAYT KYCEM LJTGL M4Z O9- P2P RNANH RVRKI TFDNU TFL TFW UEQFS UHWXJ V1S ~1N 5VS AALIY AAORF ABJNI ABLIJ ABWCV ABXYU ABZEW ACIEZ ACKZS ADFOM ADFZZ AEIIZ AFLEI AJVHN ALYBC AWYRJ BRMBE CAG CGR COF CUY CVF CYYVM CZDIS DRXRE DWTOO EAS EBC EBD EBX ECM EIF EJD EMB EMK EPL EPT JENTW M44 NPM NUSFT OVD QQXMO Q~Q TBQAZ TEORI TERGH TUROJ TUS AAYXX CITATION 7X8
ID	FETCH-LOGICAL-c366t-a3e848009e576ca84aa0072d870c4044e34b5168e2e88f5c2c51b307d1b1bf653
ISSN	0265-2048
IngestDate	Fri Oct 25 01:40:56 EDT 2024 Thu Nov 21 22:55:31 EST 2024 Wed Oct 16 00:39:05 EDT 2024 Tue Jun 13 19:25:02 EDT 2023
IsPeerReviewed	true
IsScholarly	true
Issue	2
Keywords	drug delivery systems microwave-induced plasma anti-inflammatory drugs Metallodrug biodegradable polymers
Language	English
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c366t-a3e848009e576ca84aa0072d870c4044e34b5168e2e88f5c2c51b307d1b1bf653
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0002-5063-7451
PMID	36722704
PQID	2771637270
PQPubID	23479
PageCount	15
ParticipantIDs	crossref_primary_10_1080_02652048_2023_2172469 proquest_miscellaneous_2771637270 pubmed_primary_36722704 informaworld_taylorfrancis_310_1080_02652048_2023_2172469
PublicationCentury	2000
PublicationDate	2023-02-17
PublicationDateYYYYMMDD	2023-02-17
PublicationDate_xml	– month: 02 year: 2023 text: 2023-02-17 day: 17
PublicationDecade	2020
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	Journal of microencapsulation
PublicationTitleAlternate	J Microencapsul
PublicationYear	2023
Publisher	Taylor & Francis
Publisher_xml	– name: Taylor & Francis
References	CIT0072 CIT0071 CIT0030 CIT0032 CIT0076 CIT0031 CIT0075 CIT0034 CIT0033 CIT0077 de Oliveira Silva D. (CIT0016) 2014 CIT0070 CIT0036 CIT0035 CIT0038 CIT0037 AOAC International (CIT0005) 2012 CIT0039 CIT0082 CIT0041 CIT0040 CIT0043 CIT0042 CIT0001 CIT0045 CIT0044 Ur-Rehman H. (CIT0074) 2020; 31 CIT0081 CIT0080 CIT0003 CIT0047 CIT0002 CIT0046 CIT0049 CIT0004 CIT0048 Wilson R.J. (CIT0078) 2021; 133 CIT0007 CIT0006 CIT0009 CIT0008 CIT0050 CIT0052 CIT0051 CIT0010 CIT0054 CIT0053 CIT0012 CIT0056 CIT0011 CIT0055 CIT0014 CIT0058 CIT0013 CIT0057 CIT0015 CIT0059 CIT0018 CIT0017 CIT0019 CIT0061 CIT0060 CIT0063 CIT0062 CIT0021 CIT0065 CIT0020 CIT0064 CIT0023 CIT0067 CIT0066 CIT0022 World Health Organization (CIT0079) 1992 CIT0025 CIT0069 CIT0024 CIT0068 CIT0027 CIT0026 CIT0029 CIT0028 Tsuji H. (CIT0073) 2010
References_xml	– ident: CIT0053 doi: 10.1590/S0100-40422004000500017 – ident: CIT0056 doi: 10.1039/C7NR01582H – ident: CIT0024 doi: 10.1016/j.colsurfb.2013.09.035 – volume: 133 start-page: 8040 year: 2021 ident: CIT0078 publication-title: Particuology contributor: fullname: Wilson R.J. – ident: CIT0068 doi: 10.1166/jnn.2016.12084 – ident: CIT0012 doi: 10.1002/app.51504 – ident: CIT0059 doi: 10.1016/j.colsurfb.2020.111305 – ident: CIT0017 doi: 10.2174/1567201817666200512104833 – ident: CIT0035 doi: 10.1016/j.ijpharm.2005.02.039 – ident: CIT0043 doi: 10.1039/C4CS00487F – volume-title: Validation of analytical procedures used in the examination of pharmaceutical materials (Annex 5). WHO Expert Committee on specifications for pharmaceutical preparations (32nd report) year: 1992 ident: CIT0079 contributor: fullname: World Health Organization – ident: CIT0002 doi: 10.1016/j.jinorgbio.2019.110984 – ident: CIT0036 doi: 10.1016/j.addr.2016.05.020 – ident: CIT0062 doi: 10.1021/cr970019t – ident: CIT0040 doi: 10.1016/0928-0987(93)90023-4 – ident: CIT0041 doi: 10.1039/C7DT03637J – ident: CIT0064 doi: 10.1016/j.xphs.2018.03.021 – ident: CIT0055 doi: 10.3390/ph12040146 – ident: CIT0008 doi: 10.1007/s00775-014-1143-4 – ident: CIT0052 doi: 10.1002/masy.19971220136 – ident: CIT0075 doi: 10.1016/j.ccr.2016.01.001 – ident: CIT0015 doi: 10.2174/187152010791162333 – ident: CIT0081 doi: 10.1007/s10847-011-0024-5 – ident: CIT0046 doi: 10.2147/DDDT.S119488 – ident: CIT0032 doi: 10.3109/02652040903131301 – ident: CIT0054 doi: 10.1016/j.poly.2007.12.011 – ident: CIT0010 doi: 10.1038/nbt.3330 – ident: CIT0025 doi: 10.1016/j.carbpol.2016.01.046 – ident: CIT0027 doi: 10.1016/j.ijpharm.2021.120571 – ident: CIT0007 doi: 10.1080/00032719908542934 – ident: CIT0042 doi: 10.1080/10408398.2014.970267 – ident: CIT0077 doi: 10.1111/j.2044-8317.1997.tb01147.x – ident: CIT0057 doi: 10.1016/j.trac.2012.12.015 – volume: 31 start-page: 2331 issue: 11 year: 2020 ident: CIT0074 publication-title: Journal of the Brazilian chemical society contributor: fullname: Ur-Rehman H. – ident: CIT0019 doi: 10.1016/j.polymer.2011.06.043 – volume-title: Poly(lactic acid). Bio-based plastics: materials and applications year: 2010 ident: CIT0073 contributor: fullname: Tsuji H. – ident: CIT0013 doi: 10.1016/j.msec.2017.06.004 – ident: CIT0033 doi: 10.1016/j.colsurfb.2009.09.001 – ident: CIT0014 doi: 10.1007/s00396-019-04572-9 – ident: CIT0030 doi: 10.1016/j.eurpolymj.2020.110155 – ident: CIT0034 doi: 10.1002/mabi.200700022 – ident: CIT0080 doi: 10.1016/j.tca.2007.12.009 – ident: CIT0050 doi: 10.1016/j.addr.2016.05.002 – ident: CIT0071 doi: 10.1016/j.ijpharm.2017.11.001 – ident: CIT0048 doi: 10.1016/j.polymer.2006.04.013 – ident: CIT0049 doi: 10.3390/inorganics7010002 – ident: CIT0037 doi: 10.3390/bios10120196 – ident: CIT0031 doi: 10.1016/j.ijpharm.2017.11.018 – ident: CIT0051 doi: 10.1016/S0014-3057(96)00123-1 – ident: CIT0018 doi: 10.1016/j.ijpharm.2012.07.052 – ident: CIT0063 doi: 10.1016/j.carbpol.2020.116277 – start-page: 88 volume-title: Frontiers in anti-cancer drug discovery year: 2014 ident: CIT0016 contributor: fullname: de Oliveira Silva D. – ident: CIT0060 doi: 10.1016/j.poly.2012.05.012 – ident: CIT0069 doi: 10.1016/j.ica.2019.01.030 – ident: CIT0047 doi: 10.1016/j.ijbiomac.2014.08.012 – ident: CIT0065 doi: 10.1016/j.carbpol.2017.05.086 – ident: CIT0006 doi: 10.1016/j.jchromb.2008.09.030 – ident: CIT0044 doi: 10.1016/S0731-7085(02)00142-5 – ident: CIT0003 doi: 10.1016/j.aca.2014.04.057 – ident: CIT0066 doi: 10.1016/j.poly.2020.114827 – ident: CIT0076 doi: 10.1016/j.jconrel.2016.11.025 – ident: CIT0001 doi: 10.1016/j.msec.2015.11.019 – ident: CIT0021 doi: 10.1039/C3DT52388H – ident: CIT0004 doi: 10.1016/j.msec.2016.09.080 – ident: CIT0022 doi: 10.1016/j.jinorgbio.2016.10.003 – ident: CIT0026 doi: 10.1021/ac961912f – ident: CIT0061 doi: 10.1016/j.talanta.2003.12.014 – ident: CIT0070 doi: 10.1016/j.jpba.2017.06.034 – ident: CIT0058 doi: 10.1016/S0168-3659(02)00127-X – ident: CIT0038 doi: 10.1016/j.foodchem.2012.11.074 – ident: CIT0009 doi: 10.1002/jps.2600801214 – ident: CIT0067 doi: 10.1016/j.talanta.2013.11.043 – ident: CIT0082 doi: 10.1016/j.actbio.2015.11.031 – ident: CIT0045 doi: 10.1016/j.jpba.2004.06.016 – ident: CIT0023 doi: 10.1016/j.carbpol.2019.05.027 – ident: CIT0072 doi: 10.1351/pac199971020337 – ident: CIT0039 doi: 10.1016/j.carbpol.2016.02.043 – ident: CIT0011 doi: 10.1016/j.ijpharm.2019.05.042 – ident: CIT0028 doi: 10.1016/j.jconrel.2008.08.012 – ident: CIT0020 doi: 10.1016/j.foodchem.2016.03.083 – ident: CIT0029 doi: 10.1016/j.mtchem.2018.05.002 – start-page: 1 volume-title: AOAC official methods of analysis, in guidelines for standard method performance requirements (appendix F) year: 2012 ident: CIT0005 contributor: fullname: AOAC International
SSID	ssj0005982
Score	2.4030979
Snippet	The objectives of this work are to develop nanocarrier systems for the Ru(II)-p-cymene naproxen antitumor metallodrug, [Ru(η 6 -p-cymene)(npx)Cl] or Rupcy,... The objectives of this work are to develop nanocarrier systems for the Ru(II)-p-cymene naproxen antitumor metallodrug, [Ru(η -p-cymene)(npx)Cl] or Rupcy, based...
SourceID	proquest crossref pubmed informaworld
SourceType	Aggregation Database Index Database Publisher
StartPage	67
SubjectTerms	anti-inflammatory drugs biodegradable polymers Drug Carriers - chemistry drug delivery systems Metallodrug microwave-induced plasma Microwaves Nanoparticles - chemistry Naproxen Particle Size Polyesters - chemistry Polymers - chemistry Ruthenium Spectrum Analysis
Title	Poly(lactic acid)/β-cyclodextrin based nanoparticles bearing ruthenium(II)-arene naproxen complex: preparation and characterisation. Analytical validation for metal determination by microwave-induced plasma optical emission spectrometry
URI	https://www.tandfonline.com/doi/abs/10.1080/02652048.2023.2172469 https://www.ncbi.nlm.nih.gov/pubmed/36722704 https://search.proquest.com/docview/2771637270
Volume	40
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZ2kRAvCMZt3GQkNm3KUprEuZS3UQqrxKaJFYm3yHYcqahNqqYd6t_ih_BP-A-cEztNwoYAIV6qymljJ_bnc_F3ziHkhcskGAFM2iplvs1CzmyRKs9Oe07qiIi7vkCH28lFePYpejNgg43N6gS_bvuvMw1tMNcYOfsXs72-KTTAd5hz-IRZh88_mvfzHGtHR5My-MniEgeAyT73-oO9164tV3KCUeyL-TizUIQlVsYzsJwNQc4S8ELQfTBH6ns2xjLI0XAI97AxbEzBr5H5ojR7faJwXJhoQKcQN9RmWWeBLhs7OveJdpvDw46TmuI4VRiOmVSsnLIdVOIpEgW_8Etlj7NkiSSFGej5U27lM30brFOHnj6rjBXFpAuLdnR3Q9UubwaTxGeFqVa2PmdSY9joOegB6CUt3cYfljVgkDeJavg7PgYl2hoh_0HvqxhX3qANz1G8WklewJN-zouKc5lb6GQv6v4usGZzefk9dMOts_ySq5brxcUDb1tHmpZgGV2pgtLYvF1kD3Z1FtGO0sKFBQwMf-NyNdJHJ6syKHMbokRXKamUEudacWf4odAXdtXBMXaw4hjT5W9-yiRurmySbRd2ZRAK28f9wdlpzYjqlbXV1kOvAt4wFf11XbRUuVai31-ba6XaNrpNbplFQI_18r5DNlS2Q26cGkbJDtk_17nbV0d0VIciFkd0n57XWd1Xd8l3BNaBhhVFWB2-_Pa1BSdawom24EQNnOgaTgfD4aGGEq2gRA2UXtEGkCgAiV4BEq2BRGsgUXgntAQSbQGJihW9AiSqgUQNkGgFJNoE0j3y8e1g1D-xTa0UW3pBsLC5pyIGxl9P-WEgecQ4x6IACYhjybqMKY8J3wki5aooSn3pSt8RIN8TRzgiDXzvPtnK8kw9JDTkqZN0ORNgfDG_63IRCSkdwaQfpkJ2d0mnmvZ4plPixE6VadiskxjXSWzWyS7pNRdHvChxk2rIxN5v_vu8WkkxvA48zeSZypdF7IYh2JJgfsGAHuglth6OF4QuXGCP_qHnx-RmjfknZGsxX6qnZLNIls8McH4AvTc8uQ
link.rule.ids	315,782,786,27933,27934,59868,60657
linkProvider	Taylor & Francis
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3dbtMwFLZYJwE3A8bf-D1IaNqkuWsSp0m5m0anVqxVJYrEXWQ7jhSpdas2HeS1eBDehHfgHCdZ2cXEBdwmcRLHx_b5Tr7zHcbe-0IjCBCam0yEXERScJWZgGc9L_NULP1QUcBt8Dkaf40_9kkm5zoXhmiVhKGzSijCrdU0uSkY3VDiThE3hCQ426ba320qsYQgb4ftktZ43GK7Z-f98WhL9Oi5klHUiFOrJo_nthvd2KFu6Jfe7oW63ejiwf_ox0O2V_uicFYZzyN2x9h9dndU_23fZ4eTSte6PIHpNk1rfQKHMNkqXpeP2a_JYlYezVy-FUidp8enP39wXeoZJcwXq9wC7ZYpWGkRpNdcPFA4y3DnhBWx7G2-mR8Nh8ecstMMXkkEG2PBcd7N9w-wXJlKp3xhAbsMeis17Q62wQmsuNg84PzJq2pRgB8W5gYxBqQN9ccdVyXMiY34TV4ZntsUbTyFJYKJuYTFsroNFcOjcCK4hFRSdihW5RP25aI_PR_wuo4E10G3W3AZmFigY9wzCK60jIWUJJie4lKlRUcIEwgVet3Y-CaOs1D7OvQUrn2ppzyVdcPgKWvZhTXPGUQy89KOFAodUxF2fKlipbWnhA6jTOnOAWs3tpMsK7mQxGtUWOvRTmi0k3q0D1jvTwtLChenyaqiKknwl7bvGnNM8HPQnx5pzWKzTvwIYXCArim-0LPKTq9fJ-hGPp4QL_7hyW_ZvcF0dJlcDsefXrL7dIqY7F70irWK1ca8ZjvrdPOmnom_AfH3N0g
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3dbtMwFLbYJk3cMBgwxu9BQtMmzV2TOE3KXbW1WgWrKjEk7iLbsaVKrVP1h5HX4kF4E96Bc5yEsouJC7iNYyeOj-3zOd_5DmPvQqERBAjNjRUxF4kUXFkTcdsNbKBSGcaKDtwuPyWjL-lFn2Ryek0sDNEqCUPbSijCr9U0uee5bRhxZwgbYtKbbVHq7xZlWEKMt8V20BePEX_t9M77o6sNz6PrM0ZRJU61mjCeuxq6tUHdki-92wn1m9Fg7z904yF7UHui0KtM5xG7Z9w-272q_7Xvs6NxpWpdnsL1JkhreQpHMN7oXZeP2c9xMS2Ppz7aCqSe5CdnP75zXeophcuvFhMHtFfm4KRDiF4z8UDhHMN9ExbEsXeT9ex4ODzhFJtm8E6i1xgHnvFuvr2H-cJUKuWFA-wx6I3QtL_YAi-v4k_mAWfPpMoVBfhdYWYQYUDeEH_8dVXCjLiIN_Kr4ROXo4XnMEcoMZNQzKtmKBUeHSaCD0clXYfVonzCPg_61-eXvM4iwXXU6ay4jEwq0C3uGoRWWqZCSpJLz3Gh0qIthImEioNOakKTpjbWoY4DhStfHqhA2U4cPWXbrnDmGYNE2iBvS6HQLRVxO5QqVVoHSug4sUq3D1mrMZ1sXomFZEGjwVqPdkajndWjfci6fxpYtvKnNLZKqZJFf6n7trHGDD8H_eeRzhTrZRYmCIIjdEzxhQ4qM_39OlEnCbFAPP-HJ79hu-OLQfZxOPrwgt2nEqKxB8lLtr1arM0rtrXM16_refgL-Xk17A
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Poly%28lactic+acid%29%2F%CE%B2-cyclodextrin+based+nanoparticles+bearing+ruthenium%28II%29-arene+naproxen+complex%3A+preparation+and+characterisation.+Analytical+validation+for+metal+determination+by+microwave-induced+plasma+optical+emission+spectrometry&rft.jtitle=Journal+of+microencapsulation&rft.au=Reis+Nascimento%2C+Ruan&rft.au=Pauline+Gaitan+Tabares%2C+Julie&rft.au=Marques+dos+Anjos%2C+Paulo+Neilson&rft.au=Santos%2C+Luana+Novaes&rft.date=2023-02-17&rft.pub=Taylor+%26+Francis&rft.issn=0265-2048&rft.eissn=1464-5246&rft.volume=40&rft.issue=2&rft.spage=67&rft.epage=81&rft_id=info:doi/10.1080%2F02652048.2023.2172469&rft.externalDocID=2172469
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0265-2048&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0265-2048&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0265-2048&client=summon