Novel avenues in immunotherapies for colorectal cancer

Since it is known that the immune system affects tumor growth, it has been studied if immunotherapy can be developed to combat cancer. While some successes have been claimed, the increasing knowledge on tumor-immune interactions has, however, also shown the limitations of this approach. Tumors may s...

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Bibliographic Details
Published in:	Expert review of gastroenterology & hepatology Vol. 10; no. 4; p. 465
Main Authors:	Pardieck, Iris N, Jawahier, Priscilla A, Swets, Marloes, van de Velde, Cornelis J H, Kuppen, Peter J K
Format:	Journal Article
Language:	English
Published:	England 02-04-2016
Subjects:	Animals Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Genetic Predisposition to Disease Humans Immunotherapy - methods Lymphocytes, Tumor-Infiltrating - immunology Macrophages - immunology Phenotype Treatment Outcome Tumor Escape Tumor Microenvironment colorectal cancer CRC immunotherapy immune system clinical trials tumor microenvironment cancer immunoediting
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Summary:	Since it is known that the immune system affects tumor growth, it has been studied if immunotherapy can be developed to combat cancer. While some successes have been claimed, the increasing knowledge on tumor-immune interactions has, however, also shown the limitations of this approach. Tumors may show selective outgrowth of cells escaped from immune control. Escape variants arise spontaneously due to the genetically instable nature of tumor cells. This is one of the most obvious limitations of cancer immunotherapy. However, new therapies are becoming available, designed to respond to tumor-immune escape.
ISSN:	1747-4132
DOI:	10.1586/17474124.2016.1122522