Tumour necrosis factor like cytokine 1A levels and lesion complexity in non-smoking patients with coronary artery disease

• Published in: Biomarkers Vol. 24; no. 8; pp. 764 - 770
• Main Authors: Akyüz, Aydın, Özkaramanlı Gür, Demet, Alpsoy, Şeref, Güzel, Savaş
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17-11-2019
• Subjects: Aged; Angina, Stable; atherosclerosis; Atherosclerosis - diagnosis; Biomarkers - blood; Case-Control Studies; Coronary Angiography; coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Female; gensini scoring; Humans; Male; Middle Aged; Non-Smokers; Severity of Illness Index; syntax scoring; Tumor Necrosis Factor Ligand Superfamily Member 15 - blood; Tumor Necrosis Factor-alpha - blood; Tumour necrosis factor ligand superfamily member 15; atherosclerosis; coronary artery disease; gensini scoring; syntax scoring; Tumour necrosis factor ligand superfamily member 15
• ISSN: 1354-750X; 1366-5804
• DOI: 10.1080/1354750X.2019.1685004

Background: Tumour necrosis factor like cytokine 1A (TL1A), which is a member of tumour necrosis factor alpha superfamily (TNF-α), is a novel indicator of atherosclerosis.
Objective: Smoking is an established stimulant of TNF-α. We aimed to investigate whether TLA1 plays a role in the presence and complexity of coronary artery atherosclerosis, exclusively in non-smoking patients with CAD.
Methods: We enrolled 103 participants in the study, who underwent coronary angiography for stable angina pectoris. We divided the study population into 2 groups: The CAD group consisted of 62 patients with CAD and the control group consisted of 41 subjects with non-CAD. SYNTAX and Gensini scores, indicating CAD severity and complexity, were analysed as well as TLA1 levels.
Results: TLA1 levels was higher in patients with CAD than those in controls (228[119-824] vs 178[15-418]pg/ml, p < 0.001). Presence of CAD (β ± SE = 106.29 ± 33.11, p = 0.002), Syntax score (β ± SE= 6.57 ± 1.75, p = 0.012), and Gensini score (β ± SE = 2.30 ± 0.65, p = 0.001) were found to be predictors of TL1A levels. Gensini score and Syntax score were positively correlated with TL1A levels (r = 0.420, p < 0.001, and r = 0.402, p < 0.001, respectively).
Conclusions: Non-smoker CAD patients have higher TLA1 levels that are promising biomarker for diagnosing CAD and indicating CAD lesion complexity.