Breast and dorsal spine relapse of granulocytic sarcoma after allogeneic stem cell transplantation for acute myelomonocytic leukemia: A case report

Breast and dorsal spine relapse of granulocytic sarcoma after allogeneic stem cell transplantation for acute myelomonocytic leukemia: A case report

Granulocytic sarcoma (GS) is a rare malignant tumor, and relapse is even rarer in the breast and dorsal spine following allogeneic hematopoietic stem cell transplantation. Currently, a standard treatment regimen is not available. A rare case of GS of the right breast and dorsal spine after complete...

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Bibliographic Details
Published in:World journal of clinical cases Vol. 10; no. 7; pp. 2315 - 2321
Main Authors: Li, Yuan, Xie, Yu-De, He, Shao-Jie, Hu, Jia-Mei, Li, Zhi-Sheng, Qu, Shao-Hua
Format: Journal Article
Language:English
Published: United States Baishideng Publishing Group Inc 06-03-2022
Subjects:
Case Report
Breast
Dorsal spine
Case report
Allogeneic hematopoietic stem cell transplantation
Acute myeloid leukemia
Granulocytic sarcoma
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Summary:Granulocytic sarcoma (GS) is a rare malignant tumor, and relapse is even rarer in the breast and dorsal spine following allogeneic hematopoietic stem cell transplantation. Currently, a standard treatment regimen is not available. A rare case of GS of the right breast and dorsal spine after complete remission of acute myelogenous leukemia is reported here. A 55-year-old female patient presented with a palpable, growing, painless lump as well as worsening dorsal compressive myelopathy. She had a history of acute myelomonocytic leukemia (AML M4) and achieved complete remission after chemotherapy following allogeneic hematopoietic stem cell transplantation. Imaging examinations showed the breast lump and C7-T1 epidural masses suspected of malignancy. Histologic results were compatible with GS in both the right breast and dorsal spine, which were considered extramedullary relapse of the AML treated 4 years earlier. A rare case of GS relapse following allogeneic hematopoietic stem cell transplantation and guidelines for treatment are discussed.
Bibliography:Author contributions: Li Y and He SJ contributed to manuscript drafting; Xie YD, Hu JM and Li ZS provided patient information and collected the data; Qu SH was responsible for the revision of the manuscript; all authors contributed to the article and approved the final manuscript.
Corresponding author: Shao-Hua Qu, MD, PhD, Doctor, Department of Breast Surgery, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Road West, guangzhou 510763, Guangdong Province, China. qushaohua2009@163.com
Supported by Youth Science Foundation of National Natural Science Foundation of China, No. 81702598; The Science Foundation of Guangdong Province, No. 2017A030313803; The Science and Technology Program of Guangzhou, No. 201804010011.
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v10.i7.2315